Strain Name:
C57BL/6J-MtgxR0333Btlr/Mmmh
Stock Number:
038542-MU
Citation ID:
RRID:MMRRC_038542-MU
Other Names:
R0333 (G1), C57BL/6J-MtgxR0333Btlr
Major Collection:

Gene Information

Drd1
Name: dopamine receptor D1
Synonyms: D1 receptor, Gpcr15, Drd-1, C030036C15Rik, Drd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232341
Homologene: 14253
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16579
Homologene: 7799
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170707
Homologene: 12988
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76582
Homologene: 7089
Cdc5l
Name: cell division cycle 5-like (S. pombe)
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Mtdh
Name: metadherin
Synonyms: D8Bwg1112e, 3D3/Lyric, Lyric, 2610103J23Rik, AEG-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67154
Homologene: 12089
Smad2
Name: SMAD family member 2
Synonyms: Madr2, Smad 2, Madh2, 7120426M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17126
HGNC: HGNC:6768
Homologene: 21197
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Tk2
Name: thymidine kinase 2, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57813
Homologene: 3392
Rps7
Name: ribosomal protein S7
Synonyms: S7, Mtu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20115
VEGA: 12
Homologene: 107159
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Cux2
Name: cut-like homeobox 2
Synonyms: Cux-2, Cux2, ENSMUSG00000072641, Cutl2, 1700051K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13048
Homologene: 22426
Klhl23
Name: kelch-like 23
Synonyms: C130068N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277396
Homologene: 18628
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213783
Homologene: 18897
Nrn1l
Name: neuritin 1-like
Synonyms: G630049C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234700
Homologene: 18397
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, Alas-1, ALAS-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
Tmbim6
Name: transmembrane BAX inhibitor motif containing 6
Synonyms: Tegt, Bax inhibitor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110213
Homologene: 2419
Cab39l
Name: calcium binding protein 39-like
Synonyms: 2810425O13Rik, 1500031K13Rik, MO2L, 4930520C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69008
VEGA: 14
Homologene: 69422
Tubgcp2
Name: tubulin, gamma complex associated protein 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74237
Homologene: 55980
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237782
Homologene: 16989
H2aw
Name: H2A.W histone
Synonyms: Hist3h2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319162
Homologene: 137357
Zfp708
Name: zinc finger protein 708
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432769
Homologene: 134096
Ppp2r5b
Name: protein phosphatase 2, regulatory subunit B', beta
Synonyms: B'beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225849
HGNC: HGNC:9310
Homologene: 38157
Ppara
Name: peroxisome proliferator activated receptor alpha
Synonyms: Nr1c1, PPAR-alpha, PPARalpha, Ppar, 4933429D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19013
HGNC: HGNC:9232
Homologene: 21047
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, PAR3beta, PAR3L, PAR3B, 2010002N16Rik, Als2cr19, 1810008K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228592
Homologene: 136180
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Tm6sf2
Name: transmembrane 6 superfamily member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 107770
Homologene: 77694
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 665119
VEGA: 16
Homologene: 96163
Olfr23
Name: olfactory receptor 23
Synonyms: MTPCR50, MOR135-27, GA_x6K02T2P1NL-4097159-4098136
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18321
Homologene: 115483
Gimap3
Name: GTPase, IMAP family member 3
Synonyms: 2010110D23Rik, Ian4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 83408
Homologene: 41257
Antxr1
Name: anthrax toxin receptor 1
Synonyms: 2810405N18Rik, 2310008J16Rik, Tem8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69538
Homologene: 12976
Spata2l
Name: spermatogenesis associated 2-like
Synonyms: 2610039E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78779
Homologene: 32729
Dbndd1
Name: dysbindin (dystrobrevin binding protein 1) domain containing 1
Synonyms: D8Ertd590e, 2810427I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72185
Homologene: 11433
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217218
Homologene: 35401
Olfr31
Name: olfactory receptor 31
Synonyms: MTPCR53, MOR274-1, GA_x6K02T2PLTE-6714644-6715597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18330
HGNC: HGNC:8277
Homologene: 74028
Nudcd1
Name: NudC domain containing 1
Synonyms: 4921532K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67429
VEGA: 15
Homologene: 12128
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Parkin, Park2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, OAT3, mOat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
Tctn3
Name: tectonic family member 3
Synonyms: Tect3, 4930521E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67590
Homologene: 9221
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 62,230,212 bp
  • G to A, chromosome 1 at 163,797,264 bp
  • A to G, chromosome 2 at 69,833,897 bp
  • A to G, chromosome 2 at 129,472,857 bp
  • T to G, chromosome 2 at 166,054,291 bp
  • T to A, chromosome 4 at 137,594,483 bp
  • A to T, chromosome 5 at 21,929,242 bp
  • A to G, chromosome 5 at 32,827,993 bp
  • T to C, chromosome 5 at 121,860,608 bp
  • C to A, chromosome 5 at 125,034,344 bp
  • G to A, chromosome 6 at 48,765,730 bp
  • A to G, chromosome 6 at 87,188,838 bp
  • G to A, chromosome 6 at 119,928,163 bp
  • C to T, chromosome 7 at 28,999,761 bp
  • T to C, chromosome 7 at 85,952,283 bp
  • C to A, chromosome 7 at 139,999,347 bp
  • C to T, chromosome 8 at 70,077,914 bp
  • C to T, chromosome 8 at 104,248,514 bp
  • A to G, chromosome 8 at 105,894,420 bp
  • A to G, chromosome 8 at 123,233,632 bp
  • G to T, chromosome 8 at 123,506,773 bp
  • G to A, chromosome 9 at 66,464,699 bp
  • T to C, chromosome 9 at 106,241,281 bp
  • A to C, chromosome 10 at 3,964,419 bp
  • T to C, chromosome 10 at 86,841,627 bp
  • C to A, chromosome 11 at 58,954,859 bp
  • T to C, chromosome 11 at 60,780,222 bp
  • A to T, chromosome 11 at 73,940,767 bp
  • A to T, chromosome 11 at 102,294,992 bp
  • A to G, chromosome 12 at 28,631,201 bp
  • A to G, chromosome 12 at 55,782,900 bp
  • C to A, chromosome 13 at 54,054,063 bp
  • T to C, chromosome 13 at 67,098,622 bp
  • A to G, chromosome 13 at 106,870,763 bp
  • T to C, chromosome 14 at 14,328,498 bp
  • A to G, chromosome 14 at 59,499,611 bp
  • G to A, chromosome 14 at 65,590,593 bp
  • T to A, chromosome 15 at 4,931,118 bp
  • T to C, chromosome 15 at 34,118,101 bp
  • C to A, chromosome 15 at 35,879,803 bp
  • A to G, chromosome 15 at 44,401,287 bp
  • T to A, chromosome 15 at 85,790,960 bp
  • T to C, chromosome 15 at 99,406,674 bp
  • C to T, chromosome 16 at 5,167,066 bp
  • T to C, chromosome 17 at 11,067,140 bp
  • G to T, chromosome 17 at 45,393,216 bp
  • G to A, chromosome 18 at 76,262,621 bp
  • A to G, chromosome 19 at 6,229,047 bp
  • G to A, chromosome 19 at 8,608,150 bp
  • A to T, chromosome 19 at 40,607,267 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0333 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038542-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.