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Strain Name:
C57BL/6J-MtgxR0348Btlr/Mmmh
Stock Number:
038555-MU
Citation ID:
RRID:MMRRC_038555-MU
Other Names:
R0348 (G1), C57BL/6J-MtgxR0348Btlr
Major Collection:

Strain Information

Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
Synonyms: CRD-BP, Crdbp, IMP-1, Zbp1, D030026A21Rik, D11Moh45, D11Moh40e, IMP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140486
Homologene: 4772
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Psmd7
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
Synonyms: Mov-34, Mov34
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17463
HGNC: HGNC:9565
Homologene: 2104
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 86,356,640 bp
  • C to T, chromosome 1 at 90,828,049 bp
  • G to A, chromosome 1 at 106,712,562 bp
  • T to C, chromosome 1 at 162,836,135 bp
  • C to A, chromosome 1 at 179,731,253 bp
  • A to T, chromosome 2 at 10,042,644 bp
  • T to C, chromosome 2 at 18,162,613 bp
  • G to T, chromosome 2 at 20,778,129 bp
  • T to C, chromosome 2 at 26,481,557 bp
  • A to C, chromosome 2 at 26,981,080 bp
  • T to A, chromosome 2 at 28,212,542 bp
  • A to T, chromosome 2 at 59,004,072 bp
  • T to C, chromosome 2 at 132,870,443 bp
  • T to C, chromosome 2 at 135,968,419 bp
  • G to A, chromosome 2 at 152,580,226 bp
  • A to T, chromosome 2 at 165,309,069 bp
  • A to T, chromosome 3 at 19,987,581 bp
  • A to G, chromosome 3 at 30,689,228 bp
  • G to T, chromosome 3 at 68,935,899 bp
  • G to T, chromosome 3 at 137,372,847 bp
  • A to T, chromosome 3 at 144,921,980 bp
  • A to G, chromosome 3 at 153,910,317 bp
  • A to T, chromosome 4 at 49,514,515 bp
  • T to C, chromosome 4 at 86,844,819 bp
  • T to C, chromosome 4 at 151,586,431 bp
  • A to G, chromosome 5 at 134,227,530 bp
  • G to A, chromosome 5 at 143,487,196 bp
  • T to C, chromosome 6 at 52,206,568 bp
  • G to A, chromosome 6 at 91,074,310 bp
  • G to T, chromosome 6 at 123,637,725 bp
  • A to G, chromosome 7 at 10,715,181 bp
  • T to A, chromosome 7 at 13,309,197 bp
  • T to A, chromosome 7 at 35,428,377 bp
  • T to G, chromosome 7 at 85,221,676 bp
  • T to C, chromosome 7 at 105,565,303 bp
  • G to A, chromosome 7 at 116,158,020 bp
  • G to A, chromosome 7 at 141,322,877 bp
  • T to A, chromosome 8 at 65,001,216 bp
  • T to A, chromosome 8 at 70,070,008 bp
  • T to A, chromosome 8 at 105,676,157 bp
  • A to G, chromosome 8 at 106,092,195 bp
  • T to C, chromosome 8 at 107,580,891 bp
  • A to T, chromosome 8 at 124,434,032 bp
  • A to G, chromosome 9 at 4,330,519 bp
  • A to T, chromosome 9 at 57,146,781 bp
  • A to T, chromosome 9 at 96,571,959 bp
  • G to A, chromosome 9 at 114,598,770 bp
  • T to C, chromosome 10 at 4,056,766 bp
  • T to A, chromosome 10 at 10,357,879 bp
  • T to C, chromosome 10 at 14,129,958 bp
  • T to A, chromosome 10 at 126,013,448 bp
  • T to C, chromosome 10 at 127,088,062 bp
  • T to C, chromosome 11 at 3,894,987 bp
  • C to T, chromosome 11 at 86,234,821 bp
  • T to C, chromosome 11 at 95,968,893 bp
  • T to C, chromosome 11 at 99,417,945 bp
  • T to C, chromosome 12 at 82,384,756 bp
  • C to T, chromosome 12 at 103,763,775 bp
  • T to C, chromosome 12 at 112,736,806 bp
  • T to C, chromosome 12 at 113,544,717 bp
  • T to C, chromosome 13 at 42,158,379 bp
  • T to C, chromosome 13 at 92,450,181 bp
  • A to G, chromosome 13 at 96,398,866 bp
  • G to A, chromosome 13 at 114,873,338 bp
  • A to G, chromosome 14 at 37,060,225 bp
  • A to C, chromosome 14 at 55,063,508 bp
  • C to A, chromosome 15 at 96,998,429 bp
  • T to A, chromosome 15 at 102,983,890 bp
  • T to C, chromosome 16 at 16,903,390 bp
  • C to T, chromosome 16 at 21,967,980 bp
  • C to A, chromosome 16 at 39,008,817 bp
  • T to A, chromosome 16 at 55,866,535 bp
  • A to T, chromosome 17 at 24,896,517 bp
  • A to T, chromosome 17 at 35,515,904 bp
  • C to T, chromosome 17 at 57,080,770 bp
  • T to C, chromosome 17 at 80,408,311 bp
  • T to C, chromosome 17 at 87,370,673 bp
  • A to G, chromosome 18 at 9,280,964 bp
  • A to G, chromosome 18 at 70,523,381 bp
  • C to T, chromosome 19 at 8,895,750 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0348 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038555-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.