Strain Name:
C57BL/6J-MtgxR0368Btlr/Mmmh
Stock Number:
038574-MU
Citation ID:
RRID:MMRRC_038574-MU
Other Names:
R0368 (G1), C57BL/6J-MtgxR0368Btlr
Major Collection:

Strain Information

Olig1
Name: oligodendrocyte transcription factor 1
Synonyms: Olg-1, Bhlhb6, bHLHe21
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50914
Homologene: 9667
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Dgat1
Name: diacylglycerol O-acyltransferase 1
Synonyms: D15Ertd23e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13350
HGNC: HGNC:2843
Homologene: 7688
Dnmt1
Name: DNA methyltransferase 1
Synonyms: Cxxc9, Dnmt1o, MommeD2, MTase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, Spna2, alpha-fodrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Mllt1
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Synonyms: LTG19, ENL, BAM11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64144
VEGA: 17
HGNC: HGNC:7134
Homologene: 4339
Ppp1r1c
Name: protein phosphatase 1, regulatory inhibitor subunit 1C
Synonyms: 4930565M23Rik, 4930579P15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75276
Homologene: 18170
Pafah2
Name: platelet-activating factor acetylhydrolase 2
Synonyms: 2310074E22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100163
HGNC: HGNC:8579
Homologene: 37309
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
G3bp1
Name: G3BP stress granule assembly factor 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27041
Homologene: 38096
Rab21
Name: RAB21, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216344
VEGA: 10
Homologene: 8991
Rab5b
Name: RAB5B, member RAS oncogene family
Synonyms: C030027M18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19344
VEGA: 10
HGNC: HGNC:9784
Homologene: 104027
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
Cyb5r3
Name: cytochrome b5 reductase 3
Synonyms: Dia1, 2500002N19Rik, Dia-1, 0610016L08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109754
HGNC: HGNC:2873
Homologene: 47921
Gabrr3
Name: gamma-aminobutyric acid type A receptor subunit rho 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 8430438I05Rik, 6030458L20Rik, RIP140
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: A730020P05Rik, sema, Sema6A-1, VIa, Semaq
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20358
Homologene: 32426
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Srpk2
Name: serine/arginine-rich protein specific kinase 2
Synonyms: WBP6, mSRPK2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20817
Homologene: 101663
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228608
Homologene: 69268
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20250
VEGA: 19
Homologene: 136612
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Slc1a5
Name: solute carrier family 1 (neutral amino acid transporter), member 5
Synonyms: ASCT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20514
Homologene: 21155
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: D4Rp1, Cyp4a, Msp-3, RP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Slc35b2
Name: solute carrier family 35, member B2
Synonyms: 1110003M08Rik, PAPST1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73836
VEGA: 17
Homologene: 24504
Il25
Name: interleukin 25
Synonyms: Il17e, IL-17E
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140806
VEGA: 14
Homologene: 15429
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Mocs3
Name: molybdenum cofactor synthesis 3
Synonyms: Uba4, 1700020H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69372
Homologene: 6108
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Or4k37
Name: olfactory receptor family 4 subfamily K member 37
Synonyms: GA_x6K02T2Q125-72379864-72380781, Olfr1281, MOR248-18, MOR248-14P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257979
Homologene: 73992
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: Ocilrp1, 4632413B12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70809
Homologene: 136309
Glmn
Name: glomulin, FKBP associated protein
Synonyms: 9330160J16Rik, Fap68, Fap48
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170823
Homologene: 14239
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: mNaDC-1, sodium/dicarboxylate co-transporter, Nadc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: SemG, SemG, Semag
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Synonyms: Ask2, MEKK6, MAPKKK6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53608
HGNC: HGNC:6858
Homologene: 3435
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Aox4
Name: aldehyde oxidase 4
Synonyms: 2310003G12Rik, AOH2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Slfn8
Name: schlafen 8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276950
Homologene: 45432
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, Ib, wl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Gpr45
Name: G protein-coupled receptor 45
Synonyms: PSP24alpha, 9230112G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93690
HGNC: HGNC:4503
Homologene: 5228
Cimip2a
Name: ciliary microtubule inner protein 2A
Synonyms: Fam166a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68222
Homologene: 12247
Or4k41
Name: olfactory receptor family 4 subfamily K member 41
Synonyms: MOR248-15, GA_x6K02T2Q125-72500603-72501520, Olfr1287
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257935
Wdr77
Name: WD repeat domain 77
Synonyms: 2610003I18Rik, 2610312E17Rik, p44/MEP50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70465
Homologene: 11466
Spon2
Name: spondin 2, extracellular matrix protein
Synonyms: 2310045I24Rik, M-spondin, Mindin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100689
Homologene: 40843
V1ra8
Name: vomeronasal 1 receptor, A8
Synonyms: Vmn1r-ps33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113850
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Chrnb1
Name: cholinergic receptor nicotinic beta 1 subunit
Synonyms: Acrb, Achr-2, AChR beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11443
HGNC: HGNC:1961
Homologene: 594
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Gm5087
Name: predicted gene 5087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328354
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 43,033,016 bp
  • C to T, chromosome 1 at 58,213,079 bp
  • T to A, chromosome 1 at 135,875,683 bp
  • T to C, chromosome 1 at 135,886,852 bp
  • T to A, chromosome 2 at 25,220,673 bp
  • T to C, chromosome 2 at 29,993,915 bp
  • T to C, chromosome 2 at 79,756,443 bp
  • C to T, chromosome 2 at 91,477,734 bp
  • T to C, chromosome 2 at 111,328,787 bp
  • T to C, chromosome 2 at 111,449,788 bp
  • G to A, chromosome 2 at 131,522,158 bp
  • C to T, chromosome 2 at 168,231,682 bp
  • G to A, chromosome 2 at 180,181,230 bp
  • T to C, chromosome 3 at 105,962,066 bp
  • T to C, chromosome 3 at 109,851,755 bp
  • T to A, chromosome 3 at 153,888,825 bp
  • A to G, chromosome 4 at 109,066,932 bp
  • T to A, chromosome 4 at 115,525,377 bp
  • A to G, chromosome 4 at 133,252,659 bp
  • T to C, chromosome 4 at 134,422,491 bp
  • A to T, chromosome 5 at 23,548,567 bp
  • A to T, chromosome 5 at 33,216,324 bp
  • G to A, chromosome 5 at 54,110,140 bp
  • G to A, chromosome 5 at 107,573,933 bp
  • T to C, chromosome 6 at 14,718,960 bp
  • A to G, chromosome 6 at 90,202,962 bp
  • A to G, chromosome 6 at 128,980,261 bp
  • C to T, chromosome 7 at 16,782,178 bp
  • C to T, chromosome 7 at 27,663,360 bp
  • A to T, chromosome 8 at 85,764,407 bp
  • T to C, chromosome 9 at 20,941,757 bp
  • T to C, chromosome 10 at 62,411,707 bp
  • A to T, chromosome 10 at 115,298,890 bp
  • C to T, chromosome 10 at 128,682,903 bp
  • T to C, chromosome 11 at 35,688,544 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • T to C, chromosome 11 at 68,954,693 bp
  • T to A, chromosome 11 at 69,784,757 bp
  • A to T, chromosome 11 at 78,404,800 bp
  • A to G, chromosome 11 at 83,017,132 bp
  • A to G, chromosome 12 at 101,809,714 bp
  • A to C, chromosome 13 at 100,161,782 bp
  • T to G, chromosome 14 at 13,158,923 bp
  • A to G, chromosome 14 at 54,935,174 bp
  • A to T, chromosome 14 at 59,860,212 bp
  • A to G, chromosome 14 at 67,700,347 bp
  • A to T, chromosome 15 at 76,502,809 bp
  • G to A, chromosome 15 at 83,158,792 bp
  • T to A, chromosome 16 at 35,628,100 bp
  • A to G, chromosome 16 at 59,440,596 bp
  • A to G, chromosome 16 at 76,294,016 bp
  • C to T, chromosome 16 at 91,270,652 bp
  • A to T, chromosome 17 at 19,065,827 bp
  • A to T, chromosome 17 at 20,994,607 bp
  • T to C, chromosome 17 at 45,566,463 bp
  • A to T, chromosome 17 at 56,905,860 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • A to T, chromosome 19 at 9,008,350 bp
  • A to T, chromosome 19 at 25,410,603 bp
  • G to A, chromosome 19 at 44,301,246 bp
  • A to G, chromosome 19 at 57,368,578 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0368 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038574-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.