Strain Name:
C57BL/6J-MtgxR0371Btlr/Mmmh
Stock Number:
038577-MU
Citation ID:
RRID:MMRRC_038577-MU
Other Names:
R0371 (G1), C57BL/6J-MtgxR0371Btlr
Major Collection:

Strain Information

Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: BB001228, Cxxc6, 2510010B09Rik, D10Ertd17e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Spag7
Name: sperm associated antigen 7
Synonyms: FSA-1, Fsa1l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216873
Homologene: 3595
Lactb2
Name: lactamase, beta 2
Synonyms: Cgi-83, E430032H21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212442
Homologene: 9349
Taok3
Name: TAO kinase 3
Synonyms: A430105I05Rik, 2900006A08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Cep290
Name: centrosomal protein 290
Synonyms: b2b1752Clo, Nphp6, Kiaa, b2b1454Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227195
Homologene: 9819
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, Supt6h, 5131400N11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20926
Homologene: 40661
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66585
Homologene: 3538
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Havcr1
Name: hepatitis A virus cellular receptor 1
Synonyms: KIM-1, Timd1, TIM-1, Tim1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171283
Homologene: 136301
Fat1
Name: FAT atypical cadherin 1
Synonyms: 2310038E12Rik, mFat1, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: D430019P06Rik, Zfp192, 2510038J07Rik, LD5-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93681
Homologene: 21268
Snap29
Name: synaptosomal-associated protein 29
Synonyms: 1300018G05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67474
Homologene: 3512
Tut1
Name: terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms: Tent1, Rbm21, PAPD2, 2700038E08Rik, TUTase6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70044
VEGA: 19
Homologene: 69361
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: 145kDa, SF3b150, SF3b145, SAP145, SF3b1, B230398H18Rik, 2810441F20Rik, 2610311M13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545471
Homologene: 134546
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216881
Homologene: 18590
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Zcchc7
Name: zinc finger, CCHC domain containing 7
Synonyms: D4Wsu132e, 4930572I07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 319885
Homologene: 22217
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: syne-2, 6820443O06Rik, D12Ertd777e, nesprin-2, Cpfl8, Nesp2g, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Enpep
Name: glutamyl aminopeptidase
Synonyms: APA, Ly-51, 6030431M22Rik, Ly51, Bp-1/6C3, aminopeptidase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Zfp648
Name: zinc finger protein 648
Synonyms: Gm10178, LOC207678
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100503355
Homologene: 18996
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237465
Homologene: 52182
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Grk2
Name: G protein-coupled receptor kinase 2
Synonyms: Bark-1, beta-adrenergic receptor kinase-1, beta ARK1, beta-AR kinase-1, beta ARK, Adrbk-1, Adrbk1, betaARK1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110355
HGNC: HGNC:289
Homologene: 1223
Btnl1
Name: butyrophilin-like 1
Synonyms: Btnl3, LOC240074, NG10, LOC240074
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038862
Homologene: 103816
Sik1
Name: salt inducible kinase 1
Synonyms: Msk, Snf1lk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17691
VEGA: 17
Homologene: 7847
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Or5ac23
Name: olfactory receptor family 5 subfamily AC member 23
Synonyms: GA_x54KRFPKG5P-55543875-55542958, MOR182-11P, Olfr205
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 257881
Homologene: 79469
Ctrb1
Name: chymotrypsinogen B1
Synonyms: Prt-2, 2200008D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: ENSMUSG00000040612, OTTMUSG00000021748, Dbsm1, 2810478N18Rik, D1Ertd471e, 3110063L10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Or4k77
Name: olfactory receptor family 4 subfamily K member 77
Synonyms: Olfr1283, MOR248-19, GA_x6K02T2Q125-72420217-72421134
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228443
Homologene: 133657
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
Or2a25
Name: olfactory receptor family 2 subfamily A member 25
Synonyms: GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258990
Homologene: 17457
Kdr
Name: kinase insert domain protein receptor
Synonyms: VEGFR2, Flk-1, orv, Flk1, VEGF receptor-2, vascular endothelial growth factor receptor- 2, VEGFR-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Klri2
Name: killer cell lectin-like receptor family I member 2
Synonyms: A530090P03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320407
Homologene: 86736
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: D6Ertd349e, BRAG2, cI-43
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Unc5c
Name: unc-5 netrin receptor C
Synonyms: B130051O18Rik, Unc5h3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: CLCP1, Esdn, 1700055P21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Mrs2
Name: MRS2 magnesium transporter
Synonyms: LOC380836, Mrs2l
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380836
Homologene: 31983
Gm5499
Name: predicted pseudogene 5499
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433144
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Cilp2
Name: cartilage intermediate layer protein 2
Synonyms: CLIP-2, 1110031K21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68709
Homologene: 17713
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: 1810053B01Rik, ePAB
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381404
Homologene: 77989
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Gvin-ps6
Name: GTPase, very large interferon inducible, pseudogene 6
Synonyms: Gm4759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209380
Or3a1d
Name: olfactory receptor family 3 subfamily A member 1D
Synonyms: MOR255-3, GA_x6K02T2P1NL-4481525-4480578, Olfr411
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258704
Homologene: 74999
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
Afmid
Name: arylformamidase
Synonyms: formylase, Kf, formylkynureninase, 9030621K19Rik, kynurenine formamidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71562
Homologene: 41731
Lrrc3b
Name: leucine rich repeat containing 3B
Synonyms: LRP15
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218763
VEGA: 14
Homologene: 14190
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: OAT-PG, BC026439
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,650,760 bp
  • T to C, chromosome 1 at 63,057,956 bp
  • G to A, chromosome 1 at 88,277,368 bp
  • A to T, chromosome 1 at 154,204,667 bp
  • G to A, chromosome 1 at 166,303,564 bp
  • T to C, chromosome 2 at 15,030,087 bp
  • C to T, chromosome 2 at 70,252,960 bp
  • A to T, chromosome 2 at 111,369,153 bp
  • A to G, chromosome 2 at 114,157,604 bp
  • G to T, chromosome 2 at 150,472,063 bp
  • G to A, chromosome 2 at 164,035,272 bp
  • C to A, chromosome 3 at 93,469,577 bp
  • C to T, chromosome 3 at 129,283,867 bp
  • C to T, chromosome 3 at 141,827,522 bp
  • G to C, chromosome 4 at 19,880,033 bp
  • A to G, chromosome 4 at 44,762,190 bp
  • C to G, chromosome 4 at 115,326,683 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • T to A, chromosome 5 at 75,941,834 bp
  • G to A, chromosome 5 at 96,555,331 bp
  • C to T, chromosome 5 at 117,206,687 bp
  • A to T, chromosome 6 at 42,911,938 bp
  • A to G, chromosome 6 at 90,670,403 bp
  • A to T, chromosome 6 at 112,771,471 bp
  • A to G, chromosome 6 at 129,732,143 bp
  • G to A, chromosome 7 at 30,242,158 bp
  • A to T, chromosome 7 at 106,422,779 bp
  • T to A, chromosome 7 at 118,168,300 bp
  • T to C, chromosome 8 at 44,951,892 bp
  • T to A, chromosome 8 at 45,942,806 bp
  • T to C, chromosome 8 at 69,881,606 bp
  • T to A, chromosome 8 at 111,687,151 bp
  • G to T, chromosome 9 at 79,860,091 bp
  • T to C, chromosome 10 at 62,878,399 bp
  • T to C, chromosome 10 at 76,614,473 bp
  • G to T, chromosome 10 at 93,562,812 bp
  • T to A, chromosome 10 at 100,518,564 bp
  • T to C, chromosome 10 at 117,763,769 bp
  • T to C, chromosome 11 at 46,752,589 bp
  • A to G, chromosome 11 at 70,664,796 bp
  • A to G, chromosome 11 at 71,788,723 bp
  • T to A, chromosome 11 at 74,346,934 bp
  • T to C, chromosome 11 at 78,223,157 bp
  • T to C, chromosome 11 at 115,276,089 bp
  • C to T, chromosome 11 at 117,835,140 bp
  • C to T, chromosome 12 at 13,331,095 bp
  • T to C, chromosome 12 at 75,933,845 bp
  • C to T, chromosome 12 at 86,881,643 bp
  • C to T, chromosome 13 at 21,526,674 bp
  • T to C, chromosome 13 at 24,993,095 bp
  • A to T, chromosome 14 at 15,358,560 bp
  • A to T, chromosome 14 at 47,724,003 bp
  • C to T, chromosome 14 at 97,969,903 bp
  • A to T, chromosome 15 at 57,249,735 bp
  • G to A, chromosome 16 at 4,288,047 bp
  • C to A, chromosome 16 at 17,406,203 bp
  • A to G, chromosome 16 at 58,450,823 bp
  • A to G, chromosome 16 at 59,329,222 bp
  • T to A, chromosome 17 at 18,257,294 bp
  • T to A, chromosome 17 at 19,590,132 bp
  • T to C, chromosome 17 at 31,848,984 bp
  • T to C, chromosome 17 at 34,381,057 bp
  • A to G, chromosome 17 at 87,079,100 bp
  • T to C, chromosome 19 at 4,291,586 bp
  • C to T, chromosome 19 at 5,274,824 bp
  • T to C, chromosome 19 at 8,962,773 bp
  • A to G, chromosome 19 at 48,603,894 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0371 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038577-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.