Strain Name:
C57BL/6J-MtgxR0377Btlr/Mmmh
Stock Number:
038583-MU
Citation ID:
RRID:MMRRC_038583-MU
Other Names:
R0377 (G1), C57BL/6J-MtgxR0377Btlr
Major Collection:

Gene Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Cep55
Name: centrosomal protein 55
Synonyms: 2700032M20Rik, 1200008O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74107
VEGA: 19
HGNC: HGNC:1161
Homologene: 10019
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, Mst1, sterile 20-like kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Fbxo31
Name: F-box protein 31
Synonyms: 2310046N15Rik, Fbx14, Fbxo14, 1110003O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76454
Homologene: 11684
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107182
Homologene: 31978
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104831
Homologene: 135706
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22763
Homologene: 8009
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70227
Homologene: 133818
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83925
Homologene: 8556
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Prkab2
Name: protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms: 5730553K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108097
HGNC: HGNC:9379
Homologene: 38046
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Hoxa5
Name: homeobox A5
Synonyms: Hox-1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15402
HGNC: HGNC:5106
Homologene: 40726
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Opn3
Name: opsin 3
Synonyms: ERO, Ecpn, panopsin, encephalopsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13603
Homologene: 40707
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320661
Homologene: 19716
Izumo4
Name: IZUMO family member 4
Synonyms: 9030607L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71564
VEGA: 10
Homologene: 50465
Rab5a
Name: RAB5A, member RAS oncogene family
Synonyms: 2410015H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 271457
VEGA: 17
HGNC: HGNC:9783
Homologene: 68142
Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: Tak1, transforming growth factor-beta-activated kinase 1, TGF-beta activated kinase 1, TAK1, transforming growth factor beta-activated kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26409
HGNC: HGNC:6859
Homologene: 118818
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50767
Homologene: 21333
Nutf2
Name: nuclear transport factor 2
Synonyms: PP15, Ntf2, 2700067I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68051
Homologene: 110745
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71240
Homologene: 79672
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: MFT.M05.13, Hcapg, 5730507H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54392
Homologene: 44071
Wdr18
Name: WD repeat domain 18
Synonyms: 2310012I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216156
VEGA: 10
Homologene: 32573
Gnl2
Name: guanine nucleotide binding protein-like 2 (nucleolar)
Synonyms: Ngp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230737
Homologene: 6858
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Trmt2a
Name: TRM2 tRNA methyltransferase 2A
Synonyms: Htf9c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15547
Homologene: 7374
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Rtp1
Name: receptor transporter protein 1
Synonyms: LOC239766, LOC385871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239766
VEGA: 16
Homologene: 17806
Sec14l1
Name: SEC14-like lipid binding 1
Synonyms: 1200017E04Rik, 2810012L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74136
Homologene: 37719
Olfr1080
Name: olfactory receptor 1080
Synonyms: GA_x6K02T2Q125-48039418-48038477, MOR192-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258404
Homologene: 104285
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Mll2, Wbp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242584
Homologene: 11702
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75823
Homologene: 27384
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Pcnx
Name: pecanex homolog
Synonyms: 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102632
Homologene: 49896
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Rab26
Name: RAB26, member RAS oncogene family
Synonyms: A830020M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328778
Homologene: 25655
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231760
Homologene: 14672
Abcc3
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242409
Homologene: 72894
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, osteoclast differentiation factor, OPGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Rassf9
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
Synonyms: Pamci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237504
Homologene: 3976
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269209
Homologene: 49432
Gm13547
Name: predicted gene 13547
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433416
Homologene: 136350
Sdr16c5
Name: short chain dehydrogenase/reductase family 16C, member 5
Synonyms: Scdr9, Rdhe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242285
Homologene: 15039
Spaca1
Name: sperm acrosome associated 1
Synonyms: 1700124L11Rik, 4930540L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67652
Homologene: 12170
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: 9930032O22Rik, Desc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320454
Homologene: 82239
Sult1b1
Name: sulfotransferase family 1B, member 1
Synonyms: Dopa/tyrosine sulfotransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56362
Homologene: 69169
Kcnj12
Name: potassium inwardly-rectifying channel, subfamily J, member 12
Synonyms: Kir2.2, IRK2, MB-IRK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16515
HGNC: HGNC:6258
Homologene: 7793
Gpx2
Name: glutathione peroxidase 2
Synonyms: GPx-GI, intestinal GPx, GI-GPx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14776
VEGA: 12
HGNC: HGNC:4554
Homologene: 20479
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217682
Homologene: 15090
Esp18
Name: exocrine gland secreted peptide 18
Synonyms: Gm20579
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126774
VEGA: 17
Zfp119b
Name: zinc finger protein 119b
Synonyms: BC031441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240120
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 74,612,730 bp
  • A to T, chromosome 1 at 116,292,529 bp
  • T to C, chromosome 1 at 175,663,694 bp
  • G to A, chromosome 2 at 29,761,791 bp
  • A to T, chromosome 2 at 86,553,583 bp
  • A to T, chromosome 2 at 126,125,000 bp
  • A to G, chromosome 2 at 128,641,340 bp
  • T to C, chromosome 2 at 164,096,800 bp
  • T to A, chromosome 3 at 97,662,317 bp
  • A to G, chromosome 3 at 153,896,890 bp
  • G to A, chromosome 4 at 4,005,546 bp
  • T to A, chromosome 4 at 31,985,731 bp
  • T to C, chromosome 4 at 34,044,267 bp
  • C to T, chromosome 4 at 43,674,005 bp
  • A to G, chromosome 4 at 103,048,259 bp
  • T to A, chromosome 4 at 125,046,382 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • A to T, chromosome 5 at 36,604,567 bp
  • T to C, chromosome 5 at 45,693,817 bp
  • A to T, chromosome 5 at 86,490,751 bp
  • A to T, chromosome 5 at 87,517,376 bp
  • C to T, chromosome 5 at 128,803,861 bp
  • G to A, chromosome 5 at 137,290,928 bp
  • A to T, chromosome 6 at 52,202,646 bp
  • A to G, chromosome 6 at 73,121,992 bp
  • A to G, chromosome 6 at 121,857,361 bp
  • A to G, chromosome 6 at 136,750,917 bp
  • C to A, chromosome 7 at 25,285,799 bp
  • A to T, chromosome 7 at 30,574,193 bp
  • T to A, chromosome 7 at 39,536,797 bp
  • A to G, chromosome 8 at 3,541,501 bp
  • T to C, chromosome 8 at 24,747,541 bp
  • T to A, chromosome 8 at 105,878,872 bp
  • G to A, chromosome 8 at 121,559,102 bp
  • C to T, chromosome 9 at 95,484,443 bp
  • T to A, chromosome 9 at 104,081,692 bp
  • A to T, chromosome 9 at 110,388,132 bp
  • A to G, chromosome 10 at 63,127,622 bp
  • G to A, chromosome 10 at 79,967,502 bp
  • G to A, chromosome 10 at 80,702,840 bp
  • T to A, chromosome 10 at 102,545,649 bp
  • G to A, chromosome 11 at 61,069,396 bp
  • A to G, chromosome 11 at 61,741,000 bp
  • C to A, chromosome 11 at 94,375,096 bp
  • A to G, chromosome 11 at 97,055,934 bp
  • T to G, chromosome 11 at 117,149,140 bp
  • G to A, chromosome 12 at 76,795,156 bp
  • G to A, chromosome 12 at 80,706,436 bp
  • C to T, chromosome 12 at 81,974,579 bp
  • T to C, chromosome 12 at 111,629,029 bp
  • T to C, chromosome 13 at 41,049,348 bp
  • T to G, chromosome 14 at 78,299,912 bp
  • T to C, chromosome 15 at 12,160,591 bp
  • C to A, chromosome 15 at 50,831,778 bp
  • T to A, chromosome 15 at 97,246,380 bp
  • G to A, chromosome 16 at 18,249,703 bp
  • A to G, chromosome 16 at 23,431,284 bp
  • A to T, chromosome 17 at 24,530,045 bp
  • T to A, chromosome 17 at 39,409,944 bp
  • G to A, chromosome 17 at 53,500,462 bp
  • T to A, chromosome 17 at 55,938,671 bp
  • G to A, chromosome 18 at 7,127,415 bp
  • A to G, chromosome 19 at 36,989,002 bp
  • T to A, chromosome 19 at 38,071,889 bp
  • G to A, chromosome 19 at 41,047,627 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0377 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038583-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.