Strain Name:
C57BL/6J-MtgxR0378Btlr/Mmmh
Stock Number:
038584-MU
Citation ID:
RRID:MMRRC_038584-MU
Other Names:
R0378 (G1), C57BL/6J-MtgxR0378Btlr
Major Collection:

Gene Information

Foxa3
Name: forkhead box A3
Synonyms: Hnf-3g, Tcf3g, Tcf-3g, Hnf3g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15377
HGNC: HGNC:5023
Homologene: 3308
Asna1
Name: arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Synonyms: ArsA, 1810048H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56495
HGNC: HGNC:752
Homologene: 31513
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56531
Homologene: 87707
Sephs1
Name: selenophosphate synthetase 1
Synonyms: 1110046B24Rik, SPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 109079
Homologene: 56558
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67553
Homologene: 11693
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Fto
Name: fat mass and obesity associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26383
Homologene: 8053
Srsf10
Name: serine/arginine-rich splicing factor 10
Synonyms: Nssr, Srsf13a, Fusip1, NSSR2, TASR2, FUSIP2, NSSR1, Sfrs13a, TASR1, SRrp40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14105
Homologene: 134051
Msr1
Name: macrophage scavenger receptor 1
Synonyms: MRS-A, SR-AII, SR-AI, MSR-A, Scara1, Scvr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Zfp90
Name: zinc finger protein 90
Synonyms: Nk10 expressed protein, NK10, Zfp83, KRAB17, 6430515L01Rik, Zfp64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22751
Homologene: 86800
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: ELKS2alpha, CAST, D14Ertd171e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 238988
Homologene: 69188
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Pwwp3a
Name: PWWP domain containing 3A, DNA repair factor
Synonyms: 9430059D04Rik, Mum1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 68114
Homologene: 11349
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83669
Homologene: 117682
Tmem108
Name: transmembrane protein 108
Synonyms: B130017P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 81907
Homologene: 18688
Gls2
Name: glutaminase 2 (liver, mitochondrial)
Synonyms: A330074B06Rik, Lga
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216456
Homologene: 40861
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214593
Homologene: 9689
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16564
VEGA: 15
Homologene: 56761
Olfr119
Name: olfactory receptor 119
Synonyms: GA_x6K02T2PSCP-2159633-2160598, MOR263-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258095
Homologene: 17195
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 208936
Homologene: 65241
Eri2
Name: exoribonuclease 2
Synonyms: 4933424N09Rik, Exod1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71151
Homologene: 12383
Ube2ql1
Name: ubiquitin-conjugating enzyme E2Q family-like 1
Synonyms: 3110006E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76980
VEGA: 13
Homologene: 15975
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 72303
HGNC: HGNC:2623
Homologene: 133566
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 434484
Homologene: 128391
Smg8
Name: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: 1200011M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74133
Homologene: 32393
Tcam1
Name: testicular cell adhesion molecule 1
Synonyms: 4930570F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75870
Homologene: 123944
Ncf4
Name: neutrophil cytosolic factor 4
Synonyms: p40phox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17972
HGNC: HGNC:7662
Homologene: 525
Klra5
Name: killer cell lectin-like receptor, subfamily A, member 5
Synonyms: Ly49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16636
Homologene: 110821
Vmn1r5
Name: vomeronasal 1 receptor 5
Synonyms: V1rc19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171192
Homologene: 128340
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: IIIAm1, Cyp3a, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Artn
Name: artemin
Synonyms: neublastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11876
HGNC: HGNC:727
Homologene: 7631
Oas1f
Name: 2'-5' oligoadenylate synthetase 1F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243262
HGNC: HGNC:8086
Homologene: 86720
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56388
Homologene: 135775
Olfr482
Name: olfactory receptor 482
Synonyms: GA_x6K02T2PBJ9-10424354-10423383, MOR204-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258728
Homologene: 133604
Tcerg1l
Name: transcription elongation regulator 1-like
Synonyms: 5730476P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70571
Homologene: 52165
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74549
Homologene: 12574
Amd1
Name: S-adenosylmethionine decarboxylase 1
Synonyms: SAMDC, AdoMetDC, Amd-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11702
VEGA: 10
HGNC: HGNC:457
Homologene: 1235
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Olfr820
Name: olfactory receptor 820
Synonyms: GA_x6K02T2PULF-11688441-11689379, MOR116-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258670
Homologene: 17337
Rasl10b
Name: RAS-like, family 10, member B
Synonyms: VTS58635, B230331P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 276952
Homologene: 14108
Tcl1b5
Name: T cell leukemia/lymphoma 1B, 5
Synonyms: D12Ertd644e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 27382
VEGA: 12
Homologene: 83274
Sox7
Name: SRY (sex determining region Y)-box 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 20680
VEGA: 14
Homologene: 7949
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 85,620,051 bp
  • A to G, chromosome 2 at 4,899,560 bp
  • T to A, chromosome 2 at 118,641,123 bp
  • C to A, chromosome 2 at 122,284,583 bp
  • A to T, chromosome 3 at 132,986,408 bp
  • A to G, chromosome 4 at 117,927,618 bp
  • A to G, chromosome 4 at 135,863,190 bp
  • T to G, chromosome 5 at 120,856,426 bp
  • T to C, chromosome 5 at 145,868,607 bp
  • T to A, chromosome 5 at 145,986,842 bp
  • A to T, chromosome 6 at 56,985,585 bp
  • A to T, chromosome 6 at 129,906,614 bp
  • A to G, chromosome 7 at 19,023,369 bp
  • A to T, chromosome 7 at 108,095,222 bp
  • A to G, chromosome 7 at 119,793,916 bp
  • G to A, chromosome 7 at 125,647,614 bp
  • A to G, chromosome 7 at 138,276,655 bp
  • T to C, chromosome 8 at 39,589,382 bp
  • A to G, chromosome 8 at 70,030,655 bp
  • A to T, chromosome 8 at 85,025,264 bp
  • T to C, chromosome 8 at 91,474,312 bp
  • G to A, chromosome 8 at 106,425,506 bp
  • C to A, chromosome 8 at 113,743,117 bp
  • T to C, chromosome 9 at 103,499,657 bp
  • A to T, chromosome 9 at 108,575,864 bp
  • T to C, chromosome 10 at 40,289,384 bp
  • C to A, chromosome 10 at 80,238,879 bp
  • T to C, chromosome 10 at 115,454,499 bp
  • T to G, chromosome 10 at 128,207,311 bp
  • T to A, chromosome 10 at 130,018,003 bp
  • T to C, chromosome 11 at 83,418,693 bp
  • C to A, chromosome 11 at 87,080,423 bp
  • G to A, chromosome 11 at 106,284,078 bp
  • C to T, chromosome 12 at 84,997,076 bp
  • T to A, chromosome 12 at 105,179,067 bp
  • T to A, chromosome 13 at 69,738,898 bp
  • A to G, chromosome 14 at 28,011,694 bp
  • T to C, chromosome 14 at 63,943,949 bp
  • T to C, chromosome 15 at 78,253,303 bp
  • T to C, chromosome 15 at 90,969,774 bp
  • A to G, chromosome 17 at 37,701,041 bp
  • G to T, chromosome 19 at 39,073,218 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0378 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038584-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.