Strain Name:
C57BL/6J-MtgxR0412Btlr/Mmmh
Stock Number:
038614-MU
Citation ID:
RRID:MMRRC_038614-MU
Other Names:
R0412 (G1), C57BL/6J-MtgxR0412Btlr
Major Collection:

Gene Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269132
Homologene: 22865
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57138
Homologene: 10665
Kcmf1
Name: potassium channel modulatory factor 1
Synonyms: 1700094M07Rik, clone DEBT-91, Pmcf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74287
Homologene: 99845
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: NMF335, Nav1.6, mnd-2, NaCh6, motor end-plate disease, nmf2, seal, ataxia 3, mnd2, nur14, nmf58, C630029C19Rik, med, nmf335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20273
Homologene: 7927
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, A730011F23Rik, D830032G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319974
Homologene: 22907
Cnot4
Name: CCR4-NOT transcription complex, subunit 4
Synonyms: Not4, Not4hp, Not4h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53621
HGNC: HGNC:7880
Homologene: 40870
Srsf10
Name: serine and arginine-rich splicing factor 10
Synonyms: TASR2, Nssr, TASR1, NSSR2, FUSIP2, Srsf13a, SRrp40, Sfrs13a, Fusip1, NSSR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14105
Homologene: 134051
Cdc42bpg
Name: CDC42 binding protein kinase gamma (DMPK-like)
Synonyms: MRCKgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240505
Homologene: 28384
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Syt7
Name: synaptotagmin VII
Synonyms: B230112P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54525
VEGA: 19
Homologene: 20889
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75339
Homologene: 11380
Ppp6r1
Name: protein phosphatase 6, regulatory subunit 1
Synonyms: Pp6r1, Saps1, B430201G11Rik, 2010309P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243819
Homologene: 86982
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CD222, IGF-II/CI-MPR, CI-MPR, mannose-6-phosphate receptor, cation independent, Mpr300, M6P/IGF2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69710
Homologene: 12326
Ddx41
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Synonyms: 2900024F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Xxylt1
Name: xyloside xylosyltransferase 1
Synonyms: AI480653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268880
Homologene: 17610
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229473
Homologene: 9057
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, A230048G03Rik, 2010013B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Mir700
Name: microRNA 700
Synonyms: Mirn700, mir-700, mmu-mir-700
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 735285
VEGA: 4
Pram1
Name: PML-RAR alpha-regulated adaptor molecule 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 378460
Homologene: 12963
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
4932431P20Rik
Name: RIKEN cDNA 4932431P20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Vsig2
Name: V-set and immunoglobulin domain containing 2
Synonyms: 2210413P10Rik, 1190004B15Rik, CTX, CTM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57276
VEGA: 9
Homologene: 8630
Gpr35
Name: G protein-coupled receptor 35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64095
HGNC: HGNC:4492
Homologene: 3874
Nckap1l
Name: NCK associated protein 1 like
Synonyms: 4930568P13Rik, Hem1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Atp7a, WND, Wilson protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, OTTMUSG00000020804, ENSMUSG00000044873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Tgm7
Name: transglutaminase 7
Synonyms: TGz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 640543
Homologene: 14192
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628444
Homologene: 129683
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666528
Homologene: 12991
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70598
Homologene: 6700
Ranbp6
Name: RAN binding protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240614
HGNC: HGNC:9851
Homologene: 18935
Gm6320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: hea, fsn, 1700007L07Rik, 1110035E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225049
Homologene: 12515
Olfr1036
Name: olfactory receptor 1036
Synonyms: GA_x6K02T2Q125-47549689-47550621, MOR262-13, MOR245-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258245
Olfr251
Name: olfactory receptor 251
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, D3F15S2h, DNF15S2h, Hgfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383592
Homologene: 130945
Klrb1f
Name: killer cell lectin-like receptor subfamily B member 1F
Synonyms: Nkrp1f, A630024B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232408
Homologene: 135762
H2-Bl
Name: histocompatibility 2, blastocyst
Synonyms: blastocyst MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14963
HGNC: HGNC:4931
Homologene: 128352
Olfr1233
Name: olfactory receptor 1233
Synonyms: MOR238-1, GA_x6K02T2Q125-50784973-50784056
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258974
Homologene: 74243
Zfp639
Name: zinc finger protein 639
Synonyms: 6230400O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67778
Homologene: 9473
Wdr86
Name: WD repeat domain 86
Synonyms: 2810046M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269633
Homologene: 90112
Htra3
Name: HtrA serine peptidase 3
Synonyms: 2210021K23Rik, 9530081K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78558
Homologene: 12697
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Vmn1r171
Name: vomeronasal 1 receptor 171
Synonyms: V3R7, V1rd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81012
Homologene: 128341
Fhl4
Name: four and a half LIM domains 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14202
VEGA: 10
Tbrg4
Name: transforming growth factor beta regulated gene 4
Synonyms: 2310042P22Rik, TB-12, Cpr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21379
Homologene: 31259
Olfr1385
Name: olfactory receptor 1385
Synonyms: GA_x6K02T2QP88-5941817-5940888, MOR256-42P, MOR256-41P, MOR256-42P, Olfr1549-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258027
Homologene: 86692
Gm9894
Name: predicted gene 9894
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100417934
VEGA: 13
Kcnk9
Name: potassium channel, subfamily K, member 9
Synonyms: Task3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223604
VEGA: 15
HGNC: HGNC:6283
Homologene: 56758
Mchr1
Name: melanin-concentrating hormone receptor 1
Synonyms: Gpr24, Gpr24-9, MCH-1R, Mch1r, melanin-concentrating hormone receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207911
VEGA: 15
HGNC: HGNC:4479
Homologene: 21097
Ccdc68
Name: coiled-coil domain containing 68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381175
Homologene: 11880
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,117,788 bp
  • A to T, chromosome 1 at 66,550,937 bp
  • G to T, chromosome 1 at 88,235,216 bp
  • G to T, chromosome 1 at 92,982,784 bp
  • G to T, chromosome 1 at 152,508,561 bp
  • A to G, chromosome 1 at 179,702,526 bp
  • G to A, chromosome 2 at 31,388,247 bp
  • C to T, chromosome 2 at 86,075,091 bp
  • T to A, chromosome 2 at 89,340,078 bp
  • C to A, chromosome 2 at 121,101,065 bp
  • T to A, chromosome 2 at 150,473,403 bp
  • C to T, chromosome 2 at 164,994,062 bp
  • A to C, chromosome 3 at 32,517,110 bp
  • T to C, chromosome 3 at 84,031,648 bp
  • A to T, chromosome 4 at 135,416,603 bp
  • A to G, chromosome 4 at 135,858,403 bp
  • T to A, chromosome 5 at 24,718,234 bp
  • G to T, chromosome 5 at 35,671,065 bp
  • A to G, chromosome 5 at 131,446,831 bp
  • C to A, chromosome 5 at 137,643,877 bp
  • A to G, chromosome 6 at 35,064,891 bp
  • G to A, chromosome 6 at 72,848,241 bp
  • A to T, chromosome 6 at 129,054,331 bp
  • T to G, chromosome 6 at 141,498,684 bp
  • A to G, chromosome 7 at 4,642,214 bp
  • A to G, chromosome 7 at 16,082,174 bp
  • C to T, chromosome 7 at 23,632,655 bp
  • A to G, chromosome 7 at 25,013,674 bp
  • C to G, chromosome 7 at 29,530,570 bp
  • A to C, chromosome 7 at 42,046,492 bp
  • C to A, chromosome 7 at 101,390,222 bp
  • G to T, chromosome 8 at 21,995,659 bp
  • A to G, chromosome 9 at 37,542,690 bp
  • A to C, chromosome 9 at 38,378,794 bp
  • A to T, chromosome 9 at 79,820,289 bp
  • A to C, chromosome 9 at 108,083,594 bp
  • A to G, chromosome 10 at 27,190,625 bp
  • G to T, chromosome 10 at 85,098,816 bp
  • T to C, chromosome 11 at 6,623,832 bp
  • T to A, chromosome 11 at 49,494,767 bp
  • A to G, chromosome 11 at 97,338,807 bp
  • G to T, chromosome 13 at 55,530,608 bp
  • C to T, chromosome 13 at 67,765,026 bp
  • A to G, chromosome 13 at 112,999,143 bp
  • A to C, chromosome 14 at 56,674,413 bp
  • A to G, chromosome 15 at 72,513,056 bp
  • A to T, chromosome 15 at 81,235,747 bp
  • G to C, chromosome 15 at 101,008,306 bp
  • A to T, chromosome 15 at 103,464,652 bp
  • T to A, chromosome 16 at 31,007,798 bp
  • A to T, chromosome 17 at 12,683,948 bp
  • A to T, chromosome 17 at 21,026,877 bp
  • A to G, chromosome 17 at 33,641,506 bp
  • T to A, chromosome 17 at 36,081,521 bp
  • G to A, chromosome 17 at 67,896,258 bp
  • T to C, chromosome 17 at 78,820,854 bp
  • A to G, chromosome 17 at 87,330,044 bp
  • G to T, chromosome 18 at 61,315,861 bp
  • A to G, chromosome 18 at 69,960,439 bp
  • T to G, chromosome 19 at 6,313,457 bp
  • G to T, chromosome 19 at 10,444,080 bp
  • C to T, chromosome 19 at 29,812,083 bp
  • T to C, chromosome 19 at 41,042,933 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0412 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038614-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.