Strain Name:
C57BL/6J-MtgxR0419Btlr/Mmmh
Stock Number:
038621-MU
Citation ID:
RRID:MMRRC_038621-MU
Other Names:
R0419 (G1), C57BL/6J-MtgxR0419Btlr
Major Collection:

Strain Information

Dlc1
Name: deleted in liver cancer 1
Synonyms: Arhgap7, p122-RhoGAP, STARD12, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: BAF250a, Osa1, Smarcf1, 1110030E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235469
Homologene: 17151
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Grb10
Name: growth factor receptor bound protein 10
Synonyms: Meg1, 5730571D09Rik, maternally expressed gene 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14783
HGNC: HGNC:4564
Homologene: 3882
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, hypothroid, pet
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: Duplin, 5830451P18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Kif23
Name: kinesin family member 23
Synonyms: 3110001D19Rik, Knsl5, C87313, CHO1, MKLP-1, MKLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Neo1
Name: neogenin
Synonyms: Igdcc2, 2610028H22Rik, D930014N22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Zdhhc5
Name: zinc finger, DHHC domain containing 5
Synonyms: Zisp, 1110032A17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228136
Homologene: 9147
Plekho2
Name: pleckstrin homology domain containing, family O member 2
Synonyms: Plekhq1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102595
VEGA: 9
Homologene: 11870
Gnl2
Name: guanine nucleotide binding protein nucleolar 2
Synonyms: Ngp-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230737
Homologene: 6858
5730507C01Rik
Name: RIKEN cDNA 5730507C01 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 236366
VEGA: 12
Chrne
Name: cholinergic receptor, nicotinic, epsilon polypeptide
Synonyms: AChrepsilon, Acre
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11448
HGNC: HGNC:1966
Homologene: 60
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Lamtor5
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms: 1110003H18Rik, Hbxip
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68576
Homologene: 4668
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: 68kDa, bIG-h3, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Stx2
Name: syntaxin 2
Synonyms: repro34, Syn-2, Epim, G1-536-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13852
HGNC: HGNC:3403
Homologene: 37559
Spink14
Name: serine peptidase inhibitor, Kazal type 14
Synonyms: Gm5505
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433178
Homologene: 37400
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: OSTalpha, Osta, D630035O19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106407
Homologene: 44941
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC-1, RFC1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20509
Homologene: 57139
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66957
Homologene: 41653
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, EMILIN-1, gp115
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100952
Homologene: 5117
Zfp11
Name: zinc finger protein 11
Synonyms: Zfp-11, Krox-6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22648
Homologene: 87241
1700029H14Rik
Name: RIKEN cDNA 1700029H14 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66501
Homologene: 41638
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55961
Homologene: 31893
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: DC-LAMP, Cd208, 1200002D17Rik, TSC403
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
1700101G07Rik
Name: RIKEN cDNA 1700101G07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
B3galt4
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Synonyms: Gal-T2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54218
HGNC: HGNC:919
Homologene: 2805
BC049715
Name: cDNA sequence BC049715
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320135
Homologene: 52193
Adamts5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Or5ap2
Name: olfactory receptor family 5 subfamily AP member 2
Synonyms: MOR201-2, Olfr1020, GA_x6K02T2Q125-47327964-47328917
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258573
Homologene: 45007
Pmp2
Name: peripheral myelin protein 2
Synonyms: P2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18857
HGNC: HGNC:9117
Homologene: 20589
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668101
Homologene: 82993
Prss3b
Name: serine protease 3B
Synonyms: T7, 2210010C04Rik, cationic trypsinogen (isoform T7)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67373
Homologene: 134055
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102642386
Esrp2
Name: epithelial splicing regulatory protein 2
Synonyms: Rbm35b, 9530027K23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77411
Homologene: 32617
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103149
Homologene: 9471
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, Fars1, 6720478K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Cfb
Name: complement factor B
Synonyms: Factor B, H2-Bf, alternative-complement pathway C3/C5 convertase, Bf, B, FB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14962
HGNC: HGNC:1037
Homologene: 1292
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 107,376,860 bp
  • A to C, chromosome 2 at 13,469,763 bp
  • T to A, chromosome 2 at 13,469,764 bp
  • A to T, chromosome 2 at 84,691,243 bp
  • A to T, chromosome 2 at 85,849,967 bp
  • A to T, chromosome 2 at 146,428,672 bp
  • A to T, chromosome 2 at 169,582,953 bp
  • T to C, chromosome 3 at 10,180,763 bp
  • A to T, chromosome 3 at 15,548,596 bp
  • G to T, chromosome 3 at 55,819,294 bp
  • C to A, chromosome 3 at 107,281,911 bp
  • G to A, chromosome 4 at 62,326,136 bp
  • T to G, chromosome 4 at 125,053,527 bp
  • G to T, chromosome 4 at 133,681,124 bp
  • G to T, chromosome 5 at 30,915,022 bp
  • A to G, chromosome 5 at 128,993,577 bp
  • C to T, chromosome 5 at 129,658,238 bp
  • A to T, chromosome 6 at 24,100,293 bp
  • T to C, chromosome 6 at 41,034,347 bp
  • A to G, chromosome 6 at 136,840,145 bp
  • A to G, chromosome 7 at 41,573,445 bp
  • T to C, chromosome 8 at 13,551,842 bp
  • A to T, chromosome 8 at 25,937,618 bp
  • T to C, chromosome 8 at 36,583,586 bp
  • T to C, chromosome 8 at 106,134,675 bp
  • A to G, chromosome 9 at 15,992,256 bp
  • A to G, chromosome 9 at 58,990,180 bp
  • G to A, chromosome 9 at 61,926,405 bp
  • A to G, chromosome 9 at 65,557,052 bp
  • T to C, chromosome 9 at 66,446,074 bp
  • T to C, chromosome 9 at 72,312,237 bp
  • G to T, chromosome 10 at 50,748,926 bp
  • T to C, chromosome 10 at 75,412,883 bp
  • T to A, chromosome 10 at 77,042,908 bp
  • A to T, chromosome 10 at 93,682,429 bp
  • T to C, chromosome 11 at 11,934,207 bp
  • T to C, chromosome 11 at 70,615,723 bp
  • A to T, chromosome 12 at 18,533,423 bp
  • A to G, chromosome 12 at 21,297,799 bp
  • T to C, chromosome 12 at 58,267,665 bp
  • T to A, chromosome 12 at 91,537,869 bp
  • A to G, chromosome 13 at 36,537,311 bp
  • G to T, chromosome 13 at 56,632,193 bp
  • A to C, chromosome 13 at 95,689,699 bp
  • A to T, chromosome 14 at 52,204,060 bp
  • A to T, chromosome 14 at 59,406,744 bp
  • C to T, chromosome 14 at 96,381,789 bp
  • T to C, chromosome 16 at 19,673,552 bp
  • T to A, chromosome 16 at 32,476,436 bp
  • T to C, chromosome 16 at 85,866,642 bp
  • T to C, chromosome 17 at 33,950,790 bp
  • T to C, chromosome 17 at 34,858,509 bp
  • C to T, chromosome 17 at 56,708,219 bp
  • T to C, chromosome 17 at 67,791,610 bp
  • T to C, chromosome 18 at 44,031,867 bp
  • T to A, chromosome 19 at 36,945,229 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0419 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038621-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.