Strain Name:
C57BL/6J-MtgxR0436Btlr/Mmmh
Stock Number:
038637-MU
Citation ID:
RRID:MMRRC_038637-MU
Other Names:
R0436 (G1), C57BL/6J-MtgxR0436Btlr
Major Collection:

Gene Information

Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: A230053P19Rik, D130071N24Rik, Hip14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320150
VEGA: 10
Homologene: 56324
Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 171286
Homologene: 11628
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227723
Homologene: 106649
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 52184
Homologene: 12011
Gtf2a1
Name: general transcription factor II A, 1
Synonyms: TfIIAa/b, Tfiia1, 19kDa, 37kDa, 6330549H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 83602
HGNC: HGNC:4646
Homologene: 56331
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 74493
Homologene: 11890
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 117599
Homologene: 50463
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, Bat2l2, Bat2d, 1810043M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226562
Homologene: 41015
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 26559
VEGA: 16
Homologene: 8742
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
Hk1
Name: hexokinase 1
Synonyms: Hk1-s, Hk-1, mHk1-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Cul1
Name: cullin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 26965
HGNC: HGNC:2551
Homologene: 2663
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: Ccdc128, 1110018J12Rik, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 73825
Homologene: 44811
Cep95
Name: centrosomal protein 95
Synonyms: Ccdc45, 4732496G21Rik, F630025I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 320162
Homologene: 16297
5830417I10Rik
Name: RIKEN cDNA 5830417I10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 100302730
HGNC: null
Homologene: null
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: PGHS-2, cyclooxygenase-2, Pghs2, PHS-2, COX2, Tis10, prostaglandin G/H synthase, cyclooxygenase 2, Cox-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Btbd16
Name: BTB (POZ) domain containing 16
Synonyms: E330040A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330660
Homologene: 77327
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 545030
Homologene: 83473
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241589
Homologene: 115928
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208795
Homologene: 101673
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 76217
VEGA: 18
Homologene: 8866
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: Cog2, 2700012E02Rik, 1190002B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Adrb2
Name: adrenergic receptor, beta 2
Synonyms: beta 2-adrenoceptor, beta 2-AR, Gpcr7, Adrb-2, Badm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 11555
VEGA: 18
HGNC: HGNC:286
Homologene: 30948
Trim43c
Name: tripartite motif-containing 43C
Synonyms: Trim43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 666731
HGNC: null
Homologene: 105432
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, CBF2, Cbf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12607
VEGA: 17
Homologene: 4210
Olfr601
Name: olfactory receptor 601
Synonyms: MOR24-3, GA_x6K02T2PBJ9-6068534-6067590
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258311
HGNC: null
Homologene: 64851
B230118H07Rik
Name: RIKEN cDNA B230118H07 gene
Synonyms: NWC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68170
Homologene: 16348
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: D230041A13Rik, Cmya4, UNC45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217012
Homologene: 14666
Nek4
Name: NIMA (never in mitosis gene a)-related expressed kinase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 23955
VEGA: 14
Homologene: 2376
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: 1110011D13Rik, Gup1, Mitsugumin 56, Mg56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74770
VEGA: 9
Homologene: 19287
4933430I17Rik
Name: RIKEN cDNA 4933430I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214106
Homologene: 51897
Exd2
Name: exonuclease 3'-5' domain containing 2
Synonyms: Exdl2, 4930539P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 97827
VEGA: 12
Homologene: 10066
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Wdr77
Name: WD repeat domain 77
Synonyms: p44/MEP50, 2610312E17Rik, 2610003I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70465
Homologene: 11466
H2-DMb1
Name: histocompatibility 2, class II, locus Mb1
Synonyms: H2-Mb1, H2-M beta1, H-2Mb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14999
HGNC: HGNC:4935
Homologene: 68231
Arl8a
Name: ADP-ribosylation factor-like 8A
Synonyms: 1110033P22Rik, Arl10b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68724
Homologene: 23600
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: 6230416J20Rik, D4Ertd27e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230376
Homologene: 9760
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232664
Homologene: 23378
Vmn1r4
Name: vomeronasal 1 receptor 4
Synonyms: C230065D10Rik, V1rc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171194
HGNC: null
Homologene: 131060
Msantd4
Name: Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Synonyms: 8430410K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78100
Homologene: 34935
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3, nesprin-3beta, nesprin-3alpha, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 212073
VEGA: 12
Homologene: 17625
Prrxl1
Name: paired related homeobox protein-like 1
Synonyms: Drg11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 107751
Homologene: null
Eif4ebp3
Name: eukaryotic translation initiation factor 4E binding protein 3
Synonyms: 4E-BP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 108112
HGNC: HGNC:3290
Homologene: 37841
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 135,146,980 bp
  • T to C, chromosome 1 at 150,104,277 bp
  • A to C, chromosome 1 at 162,705,314 bp
  • A to T, chromosome 1 at 180,972,733 bp
  • A to G, chromosome 2 at 31,405,612 bp
  • A to G, chromosome 2 at 32,230,660 bp
  • A to T, chromosome 2 at 93,668,357 bp
  • T to C, chromosome 2 at 101,610,519 bp
  • G to C, chromosome 2 at 104,167,950 bp
  • A to T, chromosome 2 at 120,102,341 bp
  • A to G, chromosome 3 at 27,150,095 bp
  • A to G, chromosome 3 at 88,808,655 bp
  • T to A, chromosome 3 at 105,960,026 bp
  • C to T, chromosome 3 at 145,126,116 bp
  • T to C, chromosome 4 at 62,543,445 bp
  • T to C, chromosome 4 at 86,585,807 bp
  • T to C, chromosome 5 at 137,464,902 bp
  • T to A, chromosome 6 at 29,414,934 bp
  • A to G, chromosome 6 at 47,523,773 bp
  • T to A, chromosome 6 at 56,956,962 bp
  • A to G, chromosome 7 at 45,336,133 bp
  • G to A, chromosome 7 at 46,265,936 bp
  • A to G, chromosome 7 at 103,358,741 bp
  • G to A, chromosome 7 at 130,786,053 bp
  • T to C, chromosome 8 at 104,523,236 bp
  • C to T, chromosome 8 at 123,971,001 bp
  • C to T, chromosome 8 at 124,548,514 bp
  • C to T, chromosome 9 at 4,385,180 bp
  • T to C, chromosome 9 at 54,383,750 bp
  • T to C, chromosome 9 at 88,588,187 bp
  • C to T, chromosome 9 at 121,788,762 bp
  • A to T, chromosome 10 at 62,299,275 bp
  • G to T, chromosome 10 at 93,038,975 bp
  • A to T, chromosome 10 at 110,981,990 bp
  • C to T, chromosome 10 at 120,094,212 bp
  • T to C, chromosome 11 at 82,929,567 bp
  • C to T, chromosome 11 at 100,746,932 bp
  • A to G, chromosome 11 at 106,818,685 bp
  • T to C, chromosome 12 at 80,490,770 bp
  • A to C, chromosome 12 at 91,568,273 bp
  • A to G, chromosome 12 at 104,946,924 bp
  • C to T, chromosome 14 at 30,970,472 bp
  • T to C, chromosome 14 at 32,608,083 bp
  • C to A, chromosome 14 at 33,083,812 bp
  • T to A, chromosome 16 at 33,551,085 bp
  • T to A, chromosome 16 at 90,464,154 bp
  • A to G, chromosome 17 at 34,159,656 bp
  • A to G, chromosome 17 at 78,935,650 bp
  • C to T, chromosome 17 at 88,565,689 bp
  • A to G, chromosome 18 at 36,664,301 bp
  • G to A, chromosome 18 at 43,558,169 bp
  • A to G, chromosome 18 at 62,179,553 bp
  • A to G, chromosome 19 at 36,849,358 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0436 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038637-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.