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Strain Name:
C57BL/6J-MtgxR0437Btlr/Mmmh
Stock Number:
038638-MU
Citation ID:
RRID:MMRRC_038638-MU
Other Names:
R0437 (G1), C57BL/6J-MtgxR0437Btlr
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Chrm4
Name: cholinergic receptor, muscarinic 4
Synonyms: Chrm-4, muscarinic acetylcholine receptor 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12672
HGNC: HGNC:1953
Homologene: 20192
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Szrd1
Name: SUZ RNA binding domain containing 1
Synonyms: D4Ertd22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213491
Homologene: 9213
Dhx38
Name: DEAH-box helicase 38
Synonyms: Prp16, Ddx38, 5730550P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64340
Homologene: 8512
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 83,022,565 bp
  • G to A, chromosome 1 at 174,100,399 bp
  • T to G, chromosome 1 at 188,911,031 bp
  • T to A, chromosome 2 at 4,643,761 bp
  • C to T, chromosome 2 at 5,024,115 bp
  • T to C, chromosome 2 at 25,442,845 bp
  • A to G, chromosome 2 at 66,107,229 bp
  • G to A, chromosome 2 at 69,257,295 bp
  • A to T, chromosome 2 at 71,227,825 bp
  • A to G, chromosome 2 at 76,770,530 bp
  • A to G, chromosome 2 at 82,053,791 bp
  • T to A, chromosome 2 at 88,864,885 bp
  • T to A, chromosome 2 at 89,074,612 bp
  • A to G, chromosome 2 at 91,421,953 bp
  • A to G, chromosome 2 at 91,928,443 bp
  • G to T, chromosome 2 at 92,375,592 bp
  • A to C, chromosome 2 at 93,981,569 bp
  • A to G, chromosome 2 at 181,253,973 bp
  • G to A, chromosome 3 at 19,670,978 bp
  • A to T, chromosome 3 at 36,989,804 bp
  • A to G, chromosome 3 at 53,653,015 bp
  • T to C, chromosome 3 at 96,649,137 bp
  • T to C, chromosome 4 at 43,648,082 bp
  • T to C, chromosome 4 at 99,781,889 bp
  • T to C, chromosome 4 at 123,316,897 bp
  • T to C, chromosome 4 at 140,728,929 bp
  • T to C, chromosome 4 at 141,118,744 bp
  • T to A, chromosome 5 at 25,028,505 bp
  • T to C, chromosome 5 at 73,607,687 bp
  • A to G, chromosome 5 at 124,131,089 bp
  • T to C, chromosome 5 at 124,315,568 bp
  • C to T, chromosome 5 at 127,789,785 bp
  • A to G, chromosome 6 at 50,846,938 bp
  • A to T, chromosome 6 at 97,423,463 bp
  • A to T, chromosome 6 at 125,566,318 bp
  • C to T, chromosome 7 at 6,189,409 bp
  • G to T, chromosome 7 at 15,871,146 bp
  • A to G, chromosome 7 at 15,988,762 bp
  • A to G, chromosome 7 at 18,560,711 bp
  • C to A, chromosome 7 at 24,998,967 bp
  • C to G, chromosome 7 at 30,720,101 bp
  • T to G, chromosome 7 at 43,189,310 bp
  • C to T, chromosome 7 at 56,219,815 bp
  • T to A, chromosome 7 at 97,400,337 bp
  • A to G, chromosome 7 at 100,848,784 bp
  • A to G, chromosome 7 at 126,692,581 bp
  • G to A, chromosome 8 at 40,904,526 bp
  • A to G, chromosome 8 at 60,934,537 bp
  • T to C, chromosome 8 at 70,499,514 bp
  • T to A, chromosome 8 at 79,669,997 bp
  • T to C, chromosome 8 at 94,913,426 bp
  • C to A, chromosome 8 at 95,370,772 bp
  • T to C, chromosome 8 at 109,558,629 bp
  • A to T, chromosome 9 at 15,996,932 bp
  • T to C, chromosome 10 at 60,410,797 bp
  • T to C, chromosome 10 at 128,399,847 bp
  • T to C, chromosome 10 at 130,018,096 bp
  • A to T, chromosome 10 at 130,446,543 bp
  • T to C, chromosome 11 at 34,087,229 bp
  • C to A, chromosome 11 at 53,723,906 bp
  • T to C, chromosome 11 at 55,282,799 bp
  • T to C, chromosome 11 at 58,995,088 bp
  • T to C, chromosome 11 at 72,448,848 bp
  • G to A, chromosome 11 at 74,929,701 bp
  • T to C, chromosome 11 at 78,291,536 bp
  • A to T, chromosome 11 at 94,513,512 bp
  • T to C, chromosome 11 at 116,849,294 bp
  • G to A, chromosome 11 at 117,778,261 bp
  • G to T, chromosome 11 at 117,868,575 bp
  • T to A, chromosome 12 at 4,732,759 bp
  • G to T, chromosome 12 at 16,653,695 bp
  • T to C, chromosome 12 at 16,816,445 bp
  • A to T, chromosome 12 at 104,130,670 bp
  • A to G, chromosome 13 at 21,983,205 bp
  • A to T, chromosome 13 at 22,102,061 bp
  • T to C, chromosome 13 at 22,806,356 bp
  • A to G, chromosome 13 at 27,199,464 bp
  • T to C, chromosome 13 at 75,998,495 bp
  • G to A, chromosome 13 at 100,296,924 bp
  • G to A, chromosome 13 at 119,470,095 bp
  • G to A, chromosome 14 at 64,986,369 bp
  • T to C, chromosome 15 at 53,106,106 bp
  • T to C, chromosome 15 at 77,585,408 bp
  • C to T, chromosome 15 at 79,537,471 bp
  • C to A, chromosome 15 at 79,643,988 bp
  • C to A, chromosome 15 at 89,005,312 bp
  • G to T, chromosome 16 at 5,072,184 bp
  • C to T, chromosome 16 at 45,599,887 bp
  • A to T, chromosome 16 at 97,812,559 bp
  • A to T, chromosome 17 at 21,586,998 bp
  • A to G, chromosome 17 at 32,537,098 bp
  • T to C, chromosome 17 at 33,913,624 bp
  • A to T, chromosome 17 at 46,312,919 bp
  • G to T, chromosome 17 at 46,312,920 bp
  • T to C, chromosome 18 at 5,214,910 bp
  • A to G, chromosome 18 at 33,880,273 bp
  • T to C, chromosome 18 at 36,764,499 bp
  • T to C, chromosome 18 at 46,465,781 bp
  • T to A, chromosome 19 at 11,256,569 bp
  • G to A, chromosome X at 7,824,683 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0437 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.