Strain Name:
C57BL/6J-MtgxR0442Btlr/Mmmh
Stock Number:
038643-MU
Citation ID:
RRID:MMRRC_038643-MU
Other Names:
R0442 (G1), C57BL/6J-MtgxR0442Btlr
Major Collection:

Gene Information

Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, Tg(Wap-ERBB2)229Wzw, AS3, WAP-Her-2, Her-2 Tg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, B2, AP162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 353047
Homologene: 8871
Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Synonyms: Ss, SQS, squalene synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14137
VEGA: 14
HGNC: HGNC:3629
Homologene: 3281
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75216
Homologene: 35315
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 404710
Homologene: 26400
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Grhl1
Name: grainyhead like transcription factor 1
Synonyms: p61 MGR, p70 MGR, Tcfcp2l2, LBP-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 195733
VEGA: 12
Homologene: 32219
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Rad54b
Name: RAD54 homolog B (S. cerevisiae)
Synonyms: E130016E03Rik, E130016E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 623474
Homologene: 8240
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, Dnahc2, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49o129, Ly49A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16627
Homologene: 110821
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: Rbel1b, Rbel1, Rbel1a, B230208H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227624
Homologene: 11674
Taar1
Name: trace amine-associated receptor 1
Synonyms: Trar1, Tar1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Hcn3
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonyms: Hac3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15168
Homologene: 22453
Olfr800
Name: olfactory receptor 800
Synonyms: MOR114-7, GA_x6K02T2PULF-11338429-11339364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258541
Homologene: 27203
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, Gababrbp, C330021K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76071
Homologene: 90789
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Orp1, oxygen-regulated protein 1, Dcdc3, Rp1h, mG145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214593
Homologene: 9689
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: ENaC alpha, mENaC, Scnn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20276
Homologene: 811
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, B930094H20Rik, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms: Udpgt-1a, UgtBr1, UGT1A01, Gnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394436
Homologene: 128034
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327963
Homologene: 88945
St3gal6
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Synonyms: ST3Gal VI, 1700023B24Rik, Siat10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54613
Homologene: 4448
Zbtb37
Name: zinc finger and BTB domain containing 37
Synonyms: D430004I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240869
Homologene: 13048
Gtpbp3
Name: GTP binding protein 3
Synonyms: 2410009F13Rik, Gtpbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70359
Homologene: 6600
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Sun5
Name: Sad1 and UNC84 domain containing 5
Synonyms: Spag4l, 1700021O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76407
Homologene: 12640
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Gimap9
Name: GTPase, IMAP family member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 317758
Homologene: 115637
Zfp28
Name: zinc finger protein 28
Synonyms: 2810438M17Rik, Zfp-28, mkr-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22690
Homologene: 69047
Fam90a1a
Name: family with sequence similarity 90, member A1A
Synonyms: C86695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 97476
Homologene: 135718
Use1
Name: unconventional SNARE in the ER 1 homolog (S. cerevisiae)
Synonyms: mED2, Q-SNARE, 5730403H22Rik, 2010315L10Rik, D12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67023
Homologene: 10214
Olfr312
Name: olfactory receptor 312
Synonyms: GA_x6K02T2NKPP-575829-574903, MOR222-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258065
Homologene: 77375
Nt5m
Name: 5',3'-nucleotidase, mitochondrial
Synonyms: dNT-2, 2010013E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103850
Homologene: 10622
Sstr3
Name: somatostatin receptor 3
Synonyms: Smstr3, Smstr-3, sst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20607
VEGA: 15
Homologene: 20285
Cd200
Name: CD200 antigen
Synonyms: OX2, Mox2, MRC OX-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17470
HGNC: HGNC:7203
Homologene: 4344
Olfr1475
Name: olfactory receptor 1475
Synonyms: MOR202-36, GA_x6K02T2RE5P-3812807-3811863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258298
Homologene: 77370
Minpp1
Name: multiple inositol polyphosphate histidine phosphatase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17330
VEGA: 19
HGNC: HGNC:7102
Homologene: 37980
Hif1an
Name: hypoxia-inducible factor 1, alpha subunit inhibitor
Synonyms: FIH, A830014H24Rik, 2310046M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319594
Homologene: 9906
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 4,346,747 bp
  • T to A, chromosome 1 at 25,396,470 bp
  • AT to A, chromosome 1 at 88,212,371 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • A to G, chromosome 1 at 161,032,348 bp
  • A to T, chromosome 2 at 25,587,522 bp
  • T to C, chromosome 2 at 70,238,961 bp
  • T to C, chromosome 2 at 122,289,332 bp
  • T to C, chromosome 2 at 153,870,952 bp
  • T to A, chromosome 2 at 181,232,209 bp
  • A to G, chromosome 3 at 15,802,546 bp
  • C to T, chromosome 3 at 88,115,959 bp
  • A to T, chromosome 3 at 89,151,540 bp
  • G to A, chromosome 4 at 11,609,480 bp
  • C to A, chromosome 4 at 11,610,362 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • T to G, chromosome 5 at 37,135,553 bp
  • T to A, chromosome 5 at 121,323,982 bp
  • T to C, chromosome 5 at 150,716,544 bp
  • G to T, chromosome 6 at 48,678,066 bp
  • T to G, chromosome 6 at 125,339,137 bp
  • T to C, chromosome 6 at 130,372,872 bp
  • T to C, chromosome 7 at 6,394,999 bp
  • T to C, chromosome 7 at 119,843,285 bp
  • C to T, chromosome 8 at 21,963,058 bp
  • T to C, chromosome 8 at 71,367,058 bp
  • T to A, chromosome 8 at 71,491,491 bp
  • T to C, chromosome 10 at 18,677,815 bp
  • A to G, chromosome 10 at 21,126,196 bp
  • A to G, chromosome 10 at 23,920,482 bp
  • T to A, chromosome 10 at 107,876,855 bp
  • T to C, chromosome 10 at 129,659,824 bp
  • T to A, chromosome 11 at 58,831,431 bp
  • A to T, chromosome 11 at 59,002,174 bp
  • A to G, chromosome 11 at 59,874,619 bp
  • C to A, chromosome 11 at 69,448,542 bp
  • T to C, chromosome 11 at 74,084,495 bp
  • A to G, chromosome 11 at 103,397,174 bp
  • G to A, chromosome 12 at 24,612,170 bp
  • C to T, chromosome 12 at 91,266,771 bp
  • T to A, chromosome 13 at 100,444,516 bp
  • T to C, chromosome 14 at 20,607,209 bp
  • T to C, chromosome 14 at 55,066,900 bp
  • T to C, chromosome 14 at 63,163,349 bp
  • A to T, chromosome 15 at 78,540,397 bp
  • T to A, chromosome 16 at 45,397,155 bp
  • C to A, chromosome 16 at 58,473,453 bp
  • G to T, chromosome 16 at 58,473,455 bp
  • A to T, chromosome 18 at 5,046,870 bp
  • T to G, chromosome 19 at 13,480,048 bp
  • T to C, chromosome 19 at 32,493,948 bp
  • T to G, chromosome 19 at 44,566,012 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038643-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.