Strain Name:
C57BL/6J-MtgxR0455Btlr/Mmmh
Stock Number:
038655-MU
Citation ID:
RRID:MMRRC_038655-MU
Other Names:
R0455 (G1), C57BL/6J-MtgxR0455Btlr
Major Collection:

Gene Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: EHSH1, Sh3p17, Ese1, Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20430
Homologene: 22628
Atf6
Name: activating transcription factor 6
Synonyms: ESTM49, 9130025P16Rik, Atf6alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226641
HGNC: HGNC:791
Homologene: 32015
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227800
Homologene: 49301
Fnta
Name: farnesyltransferase, CAAX box, alpha
Synonyms: FTA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14272
HGNC: HGNC:3782
Homologene: 1534
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Hdac2
Name: histone deacetylase 2
Synonyms: Yy1bp, D10Wsu179e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15182
HGNC: HGNC:4853
Homologene: 68187
Fam172a
Name: family with sequence similarity 172, member A
Synonyms: pEN87, 53-E6, 2610318O14Rik, 9430037D06Rik, 1110033M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Ccdc6
Name: coiled-coil domain containing 6
Synonyms: 2810012H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76551
Homologene: 34786
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pipp, Pib5pa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Eva1c
Name: eva-1 homolog C (C. elegans)
Synonyms: 1700092M14Rik, Fam176c, 4931408A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70967
Homologene: 14383
C1qtnf9
Name: C1q and tumor necrosis factor related protein 9
Synonyms: 9130217G22Rik, CTRP9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239126
Homologene: 18679
Gm94
Name: predicted gene 94
Synonyms: LOC225443
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225443
VEGA: 18
Homologene: 19192
Ighmbp2
Name: immunoglobulin mu binding protein 2
Synonyms: Catf1, AEP, Smbp2, sma, Smubp2, p110 subunit, RIPE3b1, Smbp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Nus1
Name: NUS1 dehydrodolichyl diphosphate synthase subunit
Synonyms: 1600027K07Rik, D10Ertd438e, NgBR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52014
Homologene: 12719
Srpr
Name: signal recognition particle receptor ('docking protein')
Synonyms: 1300011P19Rik, D11Mgi27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67398
Homologene: 2364
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70144
Homologene: 13111
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Grb7
Name: growth factor receptor bound protein 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14786
HGNC: HGNC:4567
Homologene: 3881
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212728
Homologene: 38082
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218865
Homologene: 41261
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: mGluR3, 0710001G23Rik, Gprc1c, mGlu3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Sycn
Name: syncollin
Synonyms: 0910001K16Rik, 1810038B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68416
Homologene: 12266
Ptafr
Name: platelet-activating factor receptor
Synonyms: PAFR, PAF receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19204
HGNC: HGNC:9582
Homologene: 20260
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242838
Homologene: 18247
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Vwde
Name: von Willebrand factor D and EGF domains
Synonyms: LOC232585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232585
Homologene: 35456
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: DD57, 2610044M17Rik, 5330425N03Rik, Wdr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 59002
Homologene: 9857
Ppm1h
Name: protein phosphatase 1H (PP2C domain containing)
Synonyms: ARHCL1, A430075L18Rik, C030002B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319468
Homologene: 18537
Tex14
Name: testis expressed gene 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83560
Homologene: 12838
Myorg
Name: myogenesis regulating glycosidase (putative)
Synonyms: NET37, AI464131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329828
Homologene: 19853
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22312
Homologene: 129750
Fcna
Name: ficolin A
Synonyms: ficolin A, Fcn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14133
Homologene: 117949
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70941
Homologene: 52843
Fam126b
Name: family with sequence similarity 126, member B
Synonyms: D1Ertd53e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213056
Homologene: 18184
Serpinb7
Name: serine (or cysteine) peptidase inhibitor, clade B, member 7
Synonyms: 4631416M05Rik, megsin, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116872
Homologene: 68363
Padi3
Name: peptidyl arginine deiminase, type III
Synonyms: PAD type III, Pad3, Pdi3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18601
Homologene: 7882
Olfr435
Name: olfactory receptor 435
Synonyms: GA_x6K02T2P3E9-4356476-4355535, MOR261-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258647
Homologene: 110586
Acvr2b
Name: activin receptor IIB
Synonyms: ActRIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11481
VEGA: 9
HGNC: HGNC:174
Homologene: 863
Pex13
Name: peroxisomal biogenesis factor 13
Synonyms: 2610008O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72129
HGNC: HGNC:8855
Homologene: 1967
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 117066
VEGA: 13
Olfr739
Name: olfactory receptor 739
Synonyms: GA_x6K02T2PMLR-6121675-6122604, MOR106-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258663
Homologene: 121549
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: 4930571B16Rik, Hacs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67742
Homologene: 11148
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: G alpha 10, Golf, Gna10, 9630020G10Rik, 2610011C15Rik, Galphaolf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,382,102 bp
  • T to C, chromosome 1 at 58,534,479 bp
  • T to C, chromosome 1 at 107,451,610 bp
  • A to T, chromosome 1 at 133,728,716 bp
  • A to G, chromosome 1 at 170,834,923 bp
  • T to C, chromosome 1 at 193,343,392 bp
  • T to C, chromosome 2 at 25,625,508 bp
  • T to A, chromosome 2 at 37,487,120 bp
  • T to C, chromosome 2 at 132,285,967 bp
  • G to A, chromosome 4 at 41,499,538 bp
  • C to T, chromosome 4 at 103,230,983 bp
  • A to T, chromosome 4 at 132,580,085 bp
  • T to C, chromosome 4 at 140,795,713 bp
  • T to A, chromosome 4 at 154,148,743 bp
  • T to A, chromosome 5 at 3,866,425 bp
  • T to C, chromosome 5 at 9,512,477 bp
  • T to C, chromosome 5 at 125,289,681 bp
  • A to T, chromosome 6 at 13,187,529 bp
  • A to C, chromosome 6 at 43,202,072 bp
  • A to T, chromosome 6 at 84,140,667 bp
  • A to G, chromosome 7 at 28,540,973 bp
  • T to A, chromosome 7 at 55,892,054 bp
  • T to C, chromosome 8 at 26,001,028 bp
  • C to T, chromosome 8 at 126,440,873 bp
  • A to G, chromosome 9 at 35,214,981 bp
  • A to T, chromosome 9 at 62,696,961 bp
  • C to T, chromosome 9 at 119,432,609 bp
  • C to T, chromosome 10 at 36,991,836 bp
  • T to A, chromosome 10 at 52,430,094 bp
  • T to A, chromosome 10 at 70,142,571 bp
  • G to T, chromosome 10 at 122,802,324 bp
  • G to T, chromosome 11 at 3,503,122 bp
  • C to T, chromosome 11 at 23,446,741 bp
  • T to C, chromosome 11 at 23,655,949 bp
  • G to T, chromosome 11 at 69,406,996 bp
  • A to G, chromosome 11 at 87,514,305 bp
  • T to G, chromosome 11 at 98,452,188 bp
  • G to A, chromosome 13 at 61,568,210 bp
  • T to A, chromosome 13 at 77,834,713 bp
  • A to T, chromosome 13 at 100,423,219 bp
  • A to G, chromosome 14 at 30,034,646 bp
  • A to G, chromosome 14 at 50,424,902 bp
  • A to C, chromosome 14 at 60,772,371 bp
  • T to C, chromosome 16 at 32,986,880 bp
  • C to T, chromosome 16 at 75,945,225 bp
  • T to C, chromosome 16 at 90,876,098 bp
  • C to T, chromosome 16 at 91,868,148 bp
  • T to C, chromosome 17 at 20,374,823 bp
  • T to A, chromosome 18 at 20,396,025 bp
  • G to A, chromosome 18 at 34,445,528 bp
  • T to C, chromosome 18 at 43,781,244 bp
  • C to T, chromosome 18 at 57,252,982 bp
  • C to T, chromosome 18 at 58,035,336 bp
  • C to T, chromosome 18 at 67,135,649 bp
  • T to C, chromosome 19 at 3,265,072 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0455 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038655-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.