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Strain Name:
C57BL/6J-MtgxR0503Btlr/Mmmh
Stock Number:
038698-MU
Citation ID:
RRID:MMRRC_038698-MU
Other Names:
R0503 (G1), C57BL/6J-MtgxR0503Btlr
Major Collection:

Strain Information

Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Comp
Name: cartilage oligomeric matrix protein
Synonyms: thrombospondin-5, TSP5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: KAT, 2410003J24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Nefl
Name: neurofilament, light polypeptide
Synonyms: NF-L, CMT2E, NF68, Nfl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18039
HGNC: HGNC:7739
Homologene: 4487
Crot
Name: carnitine O-octanoyltransferase
Synonyms: 1200003H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74114
HGNC: HGNC:2366
Homologene: 10899
Mphosph10
Name: M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms: 2810453H10Rik, 5730405D16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67973
HGNC: HGNC:7213
Homologene: 134741
Zkscan1
Name: zinc finger with KRAB and SCAN domains 1
Synonyms: 9230118B16Rik, 5930429A01Rik, KOX18, 9130423L19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74570
Homologene: 34523
Polr3c
Name: polymerase (RNA) III (DNA directed) polypeptide C
Synonyms: RPC62, RPC3, 4933407E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74414
Homologene: 38185
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Nktr
Name: natural killer tumor recognition sequence
Synonyms: D9Wsu172e, 5330401F18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18087
HGNC: HGNC:7833
Homologene: 122148
Kirrel1
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik, Kirrel
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170643
Homologene: 10089
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233057
Homologene: 138421
Tspan11
Name: tetraspanin 11
Synonyms: 1110014F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68498
Homologene: 23595
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 378425
Homologene: 16972
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68054
Homologene: 23588
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Or4c109
Name: olfactory receptor family 4 subfamily C member 109
Synonyms: GA_x6K02T2Q125-50468705-50467770, MOR233-8, Olfr1214
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258899
Homologene: 73984
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Cd200r2
Name: Cd200 receptor 2
Synonyms: CD200 cell surface glycoprotein receptor isoform 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 271375
Homologene: 45557
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Sky, Dtk, Etk-2, Tif, Brt, Rse, Sky
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Or4k5
Name: olfactory receptor family 4 subfamily K member 5
Synonyms: GA_x6K02T2PMLR-5839874-5838903, MOR246-6, Olfr729
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258275
Homologene: 17167
Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms: GluR1, GluR-A, Glr-1, Glur-1, Glur1, GluRA, Glr1, 2900051M01Rik, HIPA1, GluA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14799
HGNC: HGNC:4571
Homologene: 20226
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: GA_x6K02T2PVTD-33343617-33344561, MOR224-5, Olfr961
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: 4930595O22Rik, 4833412E22Rik, Ttll5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 330010
Homologene: 51912
Vmn1r196
Name: vomeronasal 1 receptor 196
Synonyms: V1rh19
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100312484
Homologene: 110880
Nck2
Name: non-catalytic region of tyrosine kinase adaptor protein 2
Synonyms: NCKbeta, Grb4, 4833426I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17974
HGNC: HGNC:7665
Homologene: 20794
Ccdc65
Name: coiled-coil domain containing 65
Synonyms: 4933417K04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105833
VEGA: 15
Homologene: 13226
Tmem39b
Name: transmembrane protein 39b
Synonyms: 6330509E05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230770
Homologene: 23069
Or51a5
Name: olfactory receptor family 51 subfamily A member 5
Synonyms: GA_x6K02T2PBJ9-5836380-5835439, MOR8-2, MOR8-7, Olfr586
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259115
Homologene: 131143
9930111J21Rik1
Name: RIKEN cDNA 9930111J21 gene 1
Synonyms: 9930111J21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 667214
Homologene: 83188
Erich2
Name: glutamate rich 2
Synonyms: 4933404M02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66748
Homologene: 75226
Clca4c-ps
Name: chloride channel accessory 4C, pseudogene
Synonyms: Clca4c, Gm18718, Gm6289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622139
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Or6f2
Name: olfactory receptor family 6 subfamily F member 2
Synonyms: GA_x6K02T2PBJ9-42327937-42328872, MOR104-4, Olfr523
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258511
Homologene: 27191
AI646023
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Or6c2b
Name: olfactory receptor family 6 subfamily C member 2B
Synonyms: GA_x6K02T2PULF-10797876-10796938, MOR114-14, Olfr769
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257667
Homologene: 121502
G6bos
Name: G6b opposite strand
Synonyms: NG31, G6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 114763
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 43,533,568 bp
  • A to T, chromosome 1 at 65,219,899 bp
  • C to T, chromosome 1 at 150,859,252 bp
  • A to T, chromosome 2 at 70,509,699 bp
  • C to A, chromosome 2 at 70,540,775 bp
  • C to T, chromosome 2 at 88,987,978 bp
  • T to C, chromosome 2 at 119,803,230 bp
  • C to T, chromosome 3 at 55,642,836 bp
  • A to G, chromosome 3 at 87,097,802 bp
  • A to T, chromosome 3 at 96,713,636 bp
  • A to T, chromosome 3 at 144,879,822 bp
  • A to T, chromosome 4 at 108,719,764 bp
  • A to G, chromosome 4 at 123,469,815 bp
  • A to C, chromosome 4 at 129,686,986 bp
  • T to C, chromosome 4 at 131,793,643 bp
  • T to C, chromosome 4 at 156,047,548 bp
  • A to G, chromosome 5 at 8,976,075 bp
  • T to A, chromosome 5 at 66,283,581 bp
  • A to T, chromosome 5 at 104,177,256 bp
  • T to A, chromosome 5 at 138,093,326 bp
  • GTCTAT to GTCTATCTAT, chromosome 6 at 72,429,157 bp
  • T to C, chromosome 6 at 127,939,112 bp
  • C to T, chromosome 7 at 3,249,377 bp
  • A to G, chromosome 7 at 29,846,020 bp
  • A to G, chromosome 7 at 44,512,570 bp
  • A to T, chromosome 7 at 64,389,893 bp
  • A to T, chromosome 7 at 103,122,436 bp
  • T to C, chromosome 7 at 140,176,441 bp
  • T to A, chromosome 7 at 141,151,797 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • A to T, chromosome 8 at 70,375,734 bp
  • C to T, chromosome 8 at 80,800,142 bp
  • A to G, chromosome 8 at 95,095,174 bp
  • A to G, chromosome 8 at 119,734,577 bp
  • A to T, chromosome 9 at 7,507,339 bp
  • A to G, chromosome 9 at 39,647,476 bp
  • A to T, chromosome 9 at 105,767,351 bp
  • T to A, chromosome 9 at 121,750,740 bp
  • A to G, chromosome 10 at 74,210,385 bp
  • T to C, chromosome 10 at 75,553,654 bp
  • T to A, chromosome 10 at 84,894,332 bp
  • T to C, chromosome 10 at 129,111,802 bp
  • T to C, chromosome 10 at 130,422,740 bp
  • T to C, chromosome 11 at 48,947,495 bp
  • T to G, chromosome 11 at 57,189,716 bp
  • A to G, chromosome 12 at 103,078,868 bp
  • C to A, chromosome 12 at 104,031,159 bp
  • G to A, chromosome 13 at 22,293,387 bp
  • T to A, chromosome 13 at 60,730,848 bp
  • T to A, chromosome 13 at 73,266,584 bp
  • G to T, chromosome 13 at 99,409,795 bp
  • A to G, chromosome 14 at 12,237,138 bp
  • T to A, chromosome 14 at 50,148,478 bp
  • T to A, chromosome 14 at 68,083,983 bp
  • G to T, chromosome 15 at 98,709,160 bp
  • T to A, chromosome 16 at 44,877,962 bp
  • A to G, chromosome 17 at 35,064,448 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0503 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038698-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.