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Strain Name:
C57BL/6J-MtgxR0524Btlr/Mmmh
Stock Number:
038717-MU
Citation ID:
RRID:MMRRC_038717-MU
Other Names:
R0524 (G1), C57BL/6J-MtgxR0524Btlr
Major Collection:

Strain Information

Ppp1cc
Name: protein phosphatase 1 catalytic subunit gamma
Synonyms: PP1C gamma 2, PP1C gamma 1, PP1C gamma, PP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19047
HGNC: HGNC:9283
Homologene: 135423
Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170753
Homologene: 64370
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock-II, B230113H15Rik, Rho-kinase, ROKalpha, Rock2m
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Acbd3
Name: acyl-Coenzyme A binding domain containing 3
Synonyms: Pap7, 8430407O11Rik, Gocap1, D1Ertd10e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170760
Homologene: 11227
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: Vps34, 5330434F23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: GBP, 2900068C24Rik, Ddxbp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Lamb2
Name: laminin, beta 2
Synonyms: Lamb-2, Lams, npht
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Zfp719
Name: zinc finger protein 719
Synonyms: C630016O21Rik, mszf6, 9430094P17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210105
Smarce1
Name: SWI/SNF related BAF chromatin remodeling complex subunit E1
Synonyms: BAF57, 2810417B20Rik, 9030408N19Rik, 5830412H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57376
Homologene: 37727
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Egfr
Name: epidermal growth factor receptor
Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Wa5, 9030024J15Rik, Errb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Clca4a
Name: chloride channel accessory 4A
Synonyms: 9130020L07Rik, Clca6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Olfml1
Name: olfactomedin-like 1
Synonyms: MVAL564, mONT2, ONT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244198
Homologene: 45688
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Rdh13
Name: retinol dehydrogenase 13 (all-trans and 9-cis)
Synonyms: 8430425D21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108841
Homologene: 121782
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214593
Homologene: 9689
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: PKK, DIk, RIP4, ANKK2, Ankrd3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Pcdh18
Name: protocadherin 18
Synonyms: PCDH68L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73173
Homologene: 10389
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: type IIb Na/Picotransporter, Npt2b, NaPi-2b, D5Ertd227e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20531
Homologene: 2297
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Fam111a
Name: family with sequence similarity 111, member A
Synonyms: 4632417K18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107373
Homologene: 49696
Gm6264
Name: predicted gene 6264
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Homologene: 139073
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2, Slp2-d, Slp2-c, Slp2-b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83671
Homologene: 131343
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: DD57, 2610044M17Rik, 5330425N03Rik, Wdr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 59002
Homologene: 9857
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218989
Homologene: 49506
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Rgr
Name: retinal G protein coupled receptor
Synonyms: RGR opsin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57811
VEGA: 14
HGNC: HGNC:9990
Homologene: 37709
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229927
HGNC: HGNC:2017
Homologene: 135610
Or5b116
Name: olfactory receptor family 5 subfamily B member 116
Synonyms: GA_x6K02T2RE5P-3777626-3778570, MOR202-38, MOR202-47_p, Olfr1471
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258231
Homologene: 79417
Nmt2
Name: N-myristoyltransferase 2
Synonyms: hNMT-2, A930001K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Ddx49
Name: DEAD box helicase 49
Synonyms: R27090_2, DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234374
Homologene: 41308
Or2g1
Name: olfactory receptor family 2 subfamily G member 1
Synonyms: MOR256-9, GA_x6K02T2PSCP-2255106-2256035, Olfr123
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258623
Homologene: 105169
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Pfkm
Name: phosphofructokinase, muscle
Synonyms: Pfk-4, Pfk4, PFK-M, PFK-A, Pfkx
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18642
VEGA: 15
HGNC: HGNC:8877
Homologene: 20101
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: SSAO, semicarbazide-sensitive amine oxidase, VAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Slc17a9
Name: solute carrier family 17, member 9
Synonyms: 1700019H03Rik, Vnut
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228993
Homologene: 76562
Bnipl
Name: BCL2/adenovirus E1B 19kD interacting protein like
Synonyms: BNIPL-2, BNIPL-1, BNIPL2, BNIPL1, PP753, BNIPL, 1700128A13Rik, BNIP-S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 171388
Homologene: 15900
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: 2810457I06Rik, TULA-2, Sts-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
Sypl1
Name: synaptophysin like 1
Synonyms: Pan I, D12Ertd446e, Pphn, Sypl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19027
Homologene: 4915
Mrpl40
Name: mitochondrial ribosomal protein L40
Synonyms: Nlvcf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 18100
Homologene: 2800
H1f11-ps
Name: H1.11 linker histone, pseudogene
Synonyms: Gm6970
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 629389
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 85,171,250 bp
  • A to T, chromosome 1 at 93,310,834 bp
  • CGAGGAGGAGGAGGAGGA to CGAGGAGGAGGAGGA, chromosome 1 at 180,747,059 bp
  • T to A, chromosome 2 at 3,305,437 bp
  • T to C, chromosome 2 at 76,725,452 bp
  • T to C, chromosome 2 at 122,281,836 bp
  • G to A, chromosome 2 at 180,737,110 bp
  • T to C, chromosome 3 at 9,609,364 bp
  • A to T, chromosome 3 at 20,012,776 bp
  • T to C, chromosome 3 at 49,755,642 bp
  • T to C, chromosome 3 at 95,249,829 bp
  • T to C, chromosome 3 at 108,401,587 bp
  • T to A, chromosome 3 at 144,825,321 bp
  • A to G, chromosome 3 at 144,969,393 bp
  • G to A, chromosome 4 at 45,256,902 bp
  • A to G, chromosome 4 at 45,283,774 bp
  • A to G, chromosome 4 at 154,145,307 bp
  • G to A, chromosome 5 at 53,064,873 bp
  • C to T, chromosome 5 at 122,172,770 bp
  • A to G, chromosome 6 at 83,379,942 bp
  • A to C, chromosome 7 at 4,444,297 bp
  • A to G, chromosome 7 at 11,669,792 bp
  • A to G, chromosome 7 at 43,589,253 bp
  • C to A, chromosome 7 at 90,381,376 bp
  • T to C, chromosome 7 at 107,590,177 bp
  • C to A, chromosome 8 at 25,700,577 bp
  • G to A, chromosome 8 at 33,669,180 bp
  • A to T, chromosome 8 at 70,296,924 bp
  • A to G, chromosome 9 at 32,322,974 bp
  • A to T, chromosome 9 at 41,016,608 bp
  • A to G, chromosome 9 at 62,952,178 bp
  • A to G, chromosome 9 at 108,484,372 bp
  • A to G, chromosome 9 at 108,485,318 bp
  • A to G, chromosome 9 at 121,252,651 bp
  • C to T, chromosome 11 at 16,908,863 bp
  • T to A, chromosome 11 at 54,690,284 bp
  • A to G, chromosome 11 at 60,720,061 bp
  • T to C, chromosome 11 at 91,575,724 bp
  • G to A, chromosome 11 at 99,214,062 bp
  • C to A, chromosome 11 at 101,337,511 bp
  • C to T, chromosome 12 at 5,018,150 bp
  • T to A, chromosome 12 at 16,971,034 bp
  • C to T, chromosome 12 at 32,967,565 bp
  • C to T, chromosome 12 at 44,283,618 bp
  • T to A, chromosome 12 at 70,207,724 bp
  • T to C, chromosome 13 at 70,800,894 bp
  • A to T, chromosome 14 at 37,038,295 bp
  • A to G, chromosome 14 at 48,472,478 bp
  • A to T, chromosome 15 at 71,462,284 bp
  • A to G, chromosome 15 at 98,131,607 bp
  • A to G, chromosome 16 at 18,873,552 bp
  • G to T, chromosome 16 at 97,755,287 bp
  • A to T, chromosome 17 at 37,795,605 bp
  • A to G, chromosome 17 at 65,485,942 bp
  • C to A, chromosome 18 at 30,324,628 bp
  • C to T, chromosome 18 at 32,013,424 bp
  • T to A, chromosome 19 at 12,588,048 bp
  • A to G, chromosome 19 at 13,445,864 bp
  • T to A, chromosome 19 at 47,170,494 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0524 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.