Strain Name:
C57BL/6J-MtgxR0530Btlr/Mmmh
Stock Number:
038722-MU
Citation ID:
RRID:MMRRC_038722-MU
Other Names:
R0530 (G1), C57BL/6J-MtgxR0530Btlr
Major Collection:

Gene Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21366
Homologene: 2291
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Cep83
Name: centrosomal protein 83
Synonyms: 2600001G24Rik, 5730513H21Rik, 4921537D05Rik, Ccdc41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77048
VEGA: 10
Homologene: 9396
Uchl5
Name: ubiquitin carboxyl-terminal esterase L5
Synonyms: Uch37, 5830413B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56207
Homologene: 9326
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20975
Homologene: 117703
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Wdr26
Name: WD repeat domain 26
Synonyms: 1600024A01Rik, Gid7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226757
Homologene: 11857
Clmp
Name: CXADR-like membrane protein
Synonyms: 9030425E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71566
Homologene: 11705
Fzd10
Name: frizzled class receptor 10
Synonyms: Fz-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 93897
HGNC: HGNC:4039
Homologene: 21411
Rbpj-ps3
Name: recombination signal binding protein for immunoglobulin kappa J region, pseudogene 3
Synonyms: Igkrsbp-rs3, Rbpsuh-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19667
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Ckap2
Name: cytoskeleton associated protein 2
Synonyms: LB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80986
HGNC: HGNC:1990
Homologene: 10070
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101185
Homologene: 32263
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240255
Homologene: 11265
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245038
Homologene: 70580
4932431P20Rik
Name: RIKEN cDNA 4932431P20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270162
VEGA: 9
Homologene: 10280
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, NIR3, Rdgb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19679
Homologene: 7915
Slc2a8
Name: solute carrier family 2, (facilitated glucose transporter), member 8
Synonyms: GLUT8, GlutX1, D2Ertd44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56017
Homologene: 69170
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27405
Homologene: 86845
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Ces1e
Name: carboxylesterase 1E
Synonyms: Es-22, Eg, egasyn, Es22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Cst7
Name: cystatin F (leukocystatin)
Synonyms: cystatin-like metastasis-associated protein, CMAP, Leukocystatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13011
HGNC: HGNC:2479
Homologene: 37832
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Clip50, CLIP-170, 1110007I12Rik, 4631429H07Rik, Rsn, Clip 170, restin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 107868
Homologene: 68408
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76484
Homologene: 45138
Prdx6b
Name: peroxiredoxin 6B
Synonyms: Aop2-rs1, 1-cysPrx-P1, 4930414C22Rik, Prdx6-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320769
Homologene: 71226
Gm9742
Name: predicted gene 9742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 791083
VEGA: 13
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665186
Homologene: 104039
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171246
Homologene: 110880
Tafa3
Name: TAFA chemokine like family member 3
Synonyms: Tafa-3, 7530404M11Rik, Sam3, Tafa3, Fam19a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329731
Homologene: 18811
Gm8258
Name: predicted gene 8258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666726
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Ldha
Name: lactate dehydrogenase A
Synonyms: lactate dehydrogenase-A, LDH-A, Ldh-1, l7R2, Ldh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16828
HGNC: HGNC:6535
Homologene: 56495
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74419
Homologene: 69456
Nat1
Name: N-acetyl transferase 1
Synonyms: Nat-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17960
Homologene: 115468
Ptpn9
Name: protein tyrosine phosphatase, non-receptor type 9
Synonyms: Meg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56294
VEGA: 9
HGNC: HGNC:9661
Homologene: 2121
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Neurl1b
Name: neuralized E3 ubiquitin protein ligase 1B
Synonyms: EG240055, Neur2, C230078M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240055
Homologene: 35443
Olfr1417
Name: olfactory receptor 1417
Synonyms: GA_x6K02T2RE5P-2172809-2171862, MOR266-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258938
Homologene: 27304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,196,813 bp
  • T to C, chromosome 1 at 93,430,317 bp
  • T to C, chromosome 1 at 143,794,344 bp
  • A to T, chromosome 1 at 181,186,070 bp
  • A to G, chromosome 2 at 12,191,816 bp
  • C to T, chromosome 2 at 32,973,684 bp
  • A to G, chromosome 2 at 80,293,315 bp
  • A to T, chromosome 2 at 150,570,515 bp
  • T to C, chromosome 3 at 104,772,171 bp
  • G to A, chromosome 4 at 102,602,651 bp
  • A to G, chromosome 4 at 134,202,910 bp
  • A to G, chromosome 5 at 104,776,086 bp
  • A to G, chromosome 5 at 104,936,054 bp
  • C to A, chromosome 5 at 123,640,531 bp
  • A to G, chromosome 5 at 124,131,201 bp
  • T to C, chromosome 5 at 128,602,013 bp
  • A to G, chromosome 6 at 25,771,541 bp
  • G to A, chromosome 6 at 46,529,905 bp
  • A to G, chromosome 6 at 91,724,958 bp
  • A to T, chromosome 7 at 10,047,717 bp
  • A to G, chromosome 7 at 29,530,120 bp
  • A to G, chromosome 7 at 46,298,244 bp
  • G to A, chromosome 7 at 46,853,993 bp
  • A to T, chromosome 7 at 139,901,237 bp
  • A to G, chromosome 8 at 22,175,972 bp
  • A to T, chromosome 8 at 43,626,531 bp
  • T to C, chromosome 8 at 66,513,179 bp
  • A to G, chromosome 8 at 67,491,325 bp
  • G to A, chromosome 8 at 93,219,521 bp
  • A to G, chromosome 9 at 40,761,006 bp
  • G to T, chromosome 9 at 50,637,569 bp
  • A to T, chromosome 9 at 53,925,976 bp
  • A to G, chromosome 9 at 57,061,133 bp
  • A to T, chromosome 9 at 111,482,721 bp
  • A to T, chromosome 10 at 94,719,588 bp
  • A to T, chromosome 12 at 81,722,482 bp
  • A to T, chromosome 12 at 103,651,794 bp
  • T to A, chromosome 13 at 8,030,005 bp
  • T to C, chromosome 13 at 13,757,306 bp
  • T to C, chromosome 13 at 22,395,497 bp
  • C to A, chromosome 13 at 119,394,721 bp
  • A to G, chromosome 14 at 47,733,243 bp
  • A to T, chromosome 14 at 103,182,459 bp
  • A to G, chromosome 15 at 4,934,395 bp
  • T to A, chromosome 17 at 6,008,105 bp
  • T to A, chromosome 17 at 26,441,545 bp
  • T to A, chromosome 18 at 44,850,398 bp
  • T to A, chromosome 18 at 57,919,536 bp
  • A to G, chromosome 19 at 11,828,192 bp
  • T to C, chromosome 19 at 16,655,206 bp
  • T to C, chromosome Y at 1,333,600 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0530 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038722-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.