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Strain Name:
C57BL/6J-MtgxR0534Btlr/Mmmh
Stock Number:
038726-MU
Citation ID:
RRID:MMRRC_038726-MU
Other Names:
R0534 (G1), C57BL/6J-MtgxR0534Btlr
Major Collection:

Strain Information

Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
Synonyms: CRD-BP, Crdbp, IMP-1, Zbp1, D030026A21Rik, D11Moh45, D11Moh40e, IMP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140486
Homologene: 4772
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Npy1r
Name: neuropeptide Y receptor Y1
Synonyms: Y1-R, Npyr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18166
HGNC: HGNC:7956
Homologene: 700
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81897
Homologene: 68126
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Dennd2b
Name: DENN domain containing 2B
Synonyms: 2610305K15Rik, 2010004M01Rik, St5, Denn2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76954
Homologene: 3951
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 67,143,900 bp
  • T to A, chromosome 1 at 153,428,568 bp
  • T to A, chromosome 2 at 63,980,791 bp
  • T to C, chromosome 2 at 119,146,370 bp
  • T to C, chromosome 3 at 14,557,273 bp
  • T to A, chromosome 4 at 116,591,268 bp
  • C to T, chromosome 4 at 122,862,719 bp
  • A to T, chromosome 5 at 21,947,408 bp
  • A to T, chromosome 5 at 31,158,132 bp
  • T to C, chromosome 5 at 121,348,476 bp
  • A to T, chromosome 6 at 25,669,824 bp
  • G to A, chromosome 6 at 67,426,588 bp
  • A to G, chromosome 6 at 115,249,841 bp
  • A to G, chromosome 6 at 115,787,236 bp
  • C to A, chromosome 7 at 25,388,186 bp
  • AGAGGAGGAGGAAGAGGAGGAGGA to AGAGGAGGAGGAGGAAGAGGAGGAGGA, chromosome 7 at 45,337,235 bp
  • C to T, chromosome 7 at 103,893,231 bp
  • A to T, chromosome 7 at 109,541,428 bp
  • A to G, chromosome 7 at 121,767,424 bp
  • T to C, chromosome 8 at 45,935,138 bp
  • C to A, chromosome 8 at 66,705,018 bp
  • C to A, chromosome 8 at 105,304,219 bp
  • C to G, chromosome 8 at 109,623,649 bp
  • GGGTGGTG to GGGTG, chromosome 8 at 111,480,540 bp
  • T to G, chromosome 9 at 27,333,062 bp
  • T to A, chromosome 9 at 106,224,887 bp
  • C to T, chromosome 9 at 115,167,178 bp
  • T to A, chromosome 10 at 29,180,956 bp
  • C to A, chromosome 10 at 81,266,853 bp
  • T to A, chromosome 10 at 82,738,408 bp
  • T to C, chromosome 10 at 116,112,802 bp
  • T to A, chromosome 11 at 59,794,199 bp
  • A to G, chromosome 11 at 95,966,796 bp
  • C to A, chromosome 11 at 115,200,828 bp
  • T to C, chromosome 12 at 82,425,280 bp
  • T to A, chromosome 12 at 100,120,130 bp
  • A to T, chromosome 13 at 62,774,594 bp
  • T to A, chromosome 13 at 104,631,616 bp
  • C to A, chromosome 13 at 105,082,254 bp
  • A to T, chromosome 14 at 70,461,759 bp
  • A to T, chromosome 15 at 25,984,568 bp
  • A to G, chromosome 15 at 45,109,249 bp
  • A to G, chromosome 15 at 81,600,896 bp
  • A to C, chromosome 16 at 17,567,904 bp
  • T to A, chromosome 16 at 93,762,505 bp
  • G to T, chromosome 16 at 96,652,172 bp
  • T to C, chromosome 17 at 29,832,900 bp
  • C to T, chromosome 18 at 74,218,891 bp
  • C to T, chromosome 19 at 10,183,065 bp
  • G to C, chromosome 19 at 10,218,162 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0534 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038726-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.