Strain Name:
C57BL/6J-MtgxR0536Btlr/Mmmh
Stock Number:
038728-MU
Citation ID:
RRID:MMRRC_038728-MU
Other Names:
R0536 (G1), C57BL/6J-MtgxR0536Btlr
Major Collection:

Gene Information

Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 22359
Homologene: 443
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 1810054D07Rik, 9130422G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69863
Homologene: 25228
Agrn
Name: agrin
Synonyms: Agrin, NMF380, nmf380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Pgm3
Name: phosphoglucomutase 3
Synonyms: Pgm-3, GlcNAc-P mutase, 2810473H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 3110065C23Rik, 6430567E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 108946
Homologene: 9182
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, LOC327983, Acac, A530025K05Rik, Acc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20743
VEGA: 19
Homologene: 48482
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105351
VEGA: 13
Homologene: 11439
Akap11
Name: A kinase (PRKA) anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Chst9
Name: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
Synonyms: 5430438D01Rik, GalNAc4ST-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 71367
Homologene: 12861
Atp6v1c2
Name: ATPase, H+ transporting, lysosomal V1 subunit C2
Synonyms: 1110038G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68775
Homologene: 15866
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 546144
Homologene: 52326
Dok7
Name: docking protein 7
Synonyms: A930013K19Rik, EF-12, Oit5, Dok-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231134
Homologene: 18210
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTP-U2, GLEPP1, PTP-oc, PTPROt, Ptpn15, PTP-phi, PTP-BK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16564
VEGA: 15
Homologene: 56761
Ikzf4
Name: IKAROS family zinc finger 4
Synonyms: A630026H08Rik, Zfpn1a4, Eos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22781
Homologene: 69103
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK108, A930019C19Rik, Mlck, nmMlck, telokin, MLCK210, 9530072E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: 4930415K13Rik, Rgsl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240816
Homologene: 129962
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Hoxb5
Name: homeobox B5
Synonyms: Hox-2.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15413
HGNC: HGNC:5116
Homologene: 37585
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66673
VEGA: 19
Homologene: 8986
Olfr695
Name: olfactory receptor 695
Synonyms: GA_x6K02T2PBJ9-9092181-9091234, MOR283-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258591
Homologene: 133597
Gm13058
Name: predicted gene 13058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 666049
Olfr617
Name: olfactory receptor 617
Synonyms: MOR31-10, GA_x6K02T2PBJ9-6306819-6307775
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258838
Homologene: 105208
Olfr938
Name: olfactory receptor 938
Synonyms: MOR171-25, GA_x6K02T2PVTD-32774646-32773699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258430
VEGA: 9
Naa30
Name: N(alpha)-acetyltransferase 30, NatC catalytic subunit
Synonyms: 5730533P17Rik, Nat12, 4930487N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70646
Homologene: 17947
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,258,664 bp
  • T to A, chromosome 1 at 153,826,181 bp
  • T to C, chromosome 2 at 29,158,248 bp
  • G to A, chromosome 2 at 69,670,210 bp
  • T to A, chromosome 3 at 86,715,532 bp
  • T to G, chromosome 3 at 152,448,828 bp
  • T to C, chromosome 4 at 83,227,198 bp
  • T to C, chromosome 4 at 143,595,569 bp
  • A to T, chromosome 4 at 156,179,553 bp
  • A to G, chromosome 5 at 35,066,482 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • T to C, chromosome 7 at 103,584,261 bp
  • T to A, chromosome 7 at 106,714,321 bp
  • G to T, chromosome 9 at 39,078,329 bp
  • G to A, chromosome 9 at 74,157,408 bp
  • C to T, chromosome 9 at 86,567,536 bp
  • T to A, chromosome 10 at 128,641,249 bp
  • T to C, chromosome 11 at 84,280,516 bp
  • T to C, chromosome 11 at 96,304,028 bp
  • A to T, chromosome 12 at 17,307,508 bp
  • A to G, chromosome 13 at 14,636,973 bp
  • C to T, chromosome 14 at 49,173,077 bp
  • A to G, chromosome 14 at 78,514,024 bp
  • C to A, chromosome 15 at 90,959,683 bp
  • T to C, chromosome 16 at 35,000,387 bp
  • C to T, chromosome 18 at 12,525,894 bp
  • G to A, chromosome 18 at 15,495,330 bp
  • T to A, chromosome 19 at 4,726,690 bp
  • G to A, chromosome 19 at 27,239,964 bp
  • C to T, chromosome 19 at 48,802,698 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0536 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038728-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.