Strain Name:
C57BL/6J-MtgxR0537Btlr/Mmmh
Stock Number:
038729-MU
Citation ID:
RRID:MMRRC_038729-MU
Other Names:
R0537 (G1), C57BL/6J-MtgxR0537Btlr
Major Collection:

Gene Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, MYH-beta/slow, beta-MHC, B-MHC, MyHC-I, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Lypd1
Name: Ly6/Plaur domain containing 1
Synonyms: C530008O16Rik, 2700050C12Rik, Lynx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72585
Homologene: 16937
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98999
Homologene: 10877
Ccdc9
Name: coiled-coil domain containing 9
Synonyms: 2600011L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243846
Homologene: 9209
Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
Synonyms: ALK3, Bmpr, BMPR-IA, 1110037I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12166
HGNC: HGNC:1076
Homologene: 20911
Picalm
Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: fit-1, fit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233489
Homologene: 111783
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Nubp1
Name: nucleotide binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26425
HGNC: HGNC:8041
Homologene: 1857
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Zfp30
Name: zinc finger protein 30
Synonyms: Zfp-30, 2610306P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22693
Homologene: 84799
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Rala
Name: v-ral simian leukemia viral oncogene A (ras related)
Synonyms: Ral, 3010001O15Rik, Rasl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56044
HGNC: HGNC:9839
Homologene: 3942
Dars2
Name: aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 5830468K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226539
Homologene: 7093
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74369
Homologene: 46535
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243499
Homologene: 11807
Dnajc1
Name: DnaJ heat shock protein family (Hsp40) member C1
Synonyms: MTJ1, Dnajl1, ERdj1, 4733401K02Rik, D230036H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13418
Homologene: 7293
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217026
Homologene: 11116
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: DMT1, DCT1, van, Nramp2, microcytic anemia, viable anaemia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18174
Homologene: 55471
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: beta4GalT-III, ESTM26, 9530061M23Rik, R74981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Wdr41
Name: WD repeat domain 41
Synonyms: MSTP048, B830029I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218460
Homologene: 23087
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
Itgal
Name: integrin alpha L
Synonyms: LFA-1, Cd11a, Ly-21, Ly-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Rd3
Name: retinal degeneration 3
Synonyms: rd-3, 3322402L07Rik, rd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74023
Homologene: 11373
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238803
Homologene: 17637
Tmem168
Name: transmembrane protein 168
Synonyms: 5730526F17Rik, 8430437G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101118
Homologene: 11202
Sec16b
Name: SEC16 homolog B (S. cerevisiae)
Synonyms: Rgpr-p117, Rgpr, Lztr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 89867
Homologene: 13227
Sart1
Name: squamous cell carcinoma antigen recognized by T cells 1
Synonyms: U5-110K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20227
VEGA: 19
Homologene: 133770
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Tcam1
Name: testicular cell adhesion molecule 1
Synonyms: 4930570F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75870
Homologene: 123944
Zfp563
Name: zinc finger protein 563
Synonyms: zinc finger protein, Zfp413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: BFIT1, 2010309H15Rik, Them1, 1110020M10Rik, Thea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329910
Homologene: 11977
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: LOC382077, 4930535E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382077
Homologene: 19641
Dpm2
Name: dolichol-phosphate (beta-D) mannosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13481
HGNC: HGNC:3006
Homologene: 99726
Olfr1140
Name: olfactory receptor 1140
Synonyms: GA_x6K02T2Q125-49250025-49250960, MOR177-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258635
Homologene: 74081
Try4
Name: trypsin 4
Synonyms: Td, 0910001B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22074
HGNC: HGNC:9486
Homologene: 106639
Tmem80
Name: transmembrane protein 80
Synonyms: 5530601I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71448
Homologene: 23629
Olfr832
Name: olfactory receptor 832
Synonyms: GA_x6K02T2PVTD-12687800-12688738, MOR153-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Klhdc8b
Name: kelch domain containing 8B
Synonyms: 4931406O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78267
Homologene: 45463
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: Glut12, GLUT-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353169
Homologene: 59263
Gm17352
Name: predicted gene, 17352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 630612
VEGA: 13
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218921
Homologene: 138428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 125,912,867 bp
  • A to T, chromosome 1 at 157,147,792 bp
  • A to G, chromosome 1 at 157,537,546 bp
  • A to T, chromosome 1 at 161,060,748 bp
  • T to C, chromosome 1 at 171,274,251 bp
  • A to G, chromosome 1 at 191,983,540 bp
  • G to T, chromosome 2 at 17,404,215 bp
  • A to T, chromosome 2 at 18,307,956 bp
  • T to A, chromosome 2 at 32,572,949 bp
  • G to A, chromosome 2 at 69,670,210 bp
  • A to T, chromosome 2 at 87,746,673 bp
  • T to C, chromosome 2 at 167,041,701 bp
  • C to A, chromosome 3 at 98,116,741 bp
  • T to C, chromosome 3 at 100,125,302 bp
  • T to C, chromosome 4 at 106,762,455 bp
  • C to T, chromosome 4 at 148,538,360 bp
  • C to A, chromosome 6 at 13,603,361 bp
  • T to A, chromosome 6 at 41,304,362 bp
  • A to T, chromosome 6 at 80,022,120 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 7 at 16,280,776 bp
  • A to T, chromosome 7 at 29,792,735 bp
  • T to C, chromosome 7 at 44,535,092 bp
  • T to C, chromosome 7 at 45,440,001 bp
  • C to A, chromosome 7 at 90,130,668 bp
  • G to A, chromosome 7 at 127,311,273 bp
  • A to G, chromosome 7 at 141,333,696 bp
  • T to C, chromosome 9 at 18,945,148 bp
  • T to C, chromosome 9 at 58,117,454 bp
  • G to C, chromosome 9 at 108,449,223 bp
  • G to A, chromosome 10 at 22,665,068 bp
  • T to C, chromosome 11 at 36,163,730 bp
  • G to T, chromosome 11 at 83,779,464 bp
  • G to A, chromosome 11 at 106,284,078 bp
  • A to T, chromosome 13 at 17,888,648 bp
  • A to G, chromosome 13 at 94,995,305 bp
  • A to T, chromosome 13 at 97,760,563 bp
  • A to T, chromosome 13 at 97,957,716 bp
  • A to C, chromosome 13 at 99,229,278 bp
  • T to C, chromosome 14 at 34,443,812 bp
  • A to T, chromosome 14 at 36,096,700 bp
  • A to G, chromosome 14 at 54,990,799 bp
  • T to A, chromosome 14 at 84,447,457 bp
  • T to C, chromosome 15 at 82,091,361 bp
  • C to T, chromosome 15 at 100,405,798 bp
  • T to C, chromosome 16 at 10,422,814 bp
  • A to T, chromosome 17 at 33,104,685 bp
  • A to T, chromosome 17 at 85,394,659 bp
  • T to C, chromosome 18 at 20,458,571 bp
  • A to T, chromosome 19 at 5,381,724 bp
  • A to G, chromosome 19 at 25,171,577 bp
  • C to A, chromosome 19 at 27,247,918 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0537 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038729-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.