Strain Name:
C57BL/6J-MtgxR0553Btlr/Mmmh
Stock Number:
038745-MU
Citation ID:
RRID:MMRRC_038745-MU
Other Names:
R0553 (G1), C57BL/6J-MtgxR0553Btlr
Major Collection:

Gene Information

Cd40
Name: CD40 antigen
Synonyms: Cd40, Bp50, p50, Tnfrsf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21939
Homologene: 954
Pou5f1
Name: POU domain, class 5, transcription factor 1
Synonyms: Oct4, Oct3/4, Oct-3/4, Otf4, Otf3, Otf3g, Otf3-rs7, Otf-4, Otf-3, Oct-4, Oct-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18999
Homologene: 8422
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: 1810043O07Rik, LSD1, Aof2, Kdm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 99982
Homologene: 32240
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: Fbx13, C130023C01Rik, 6330576B01Rik, Fbxo13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50758
Homologene: 79859
Mmp17
Name: matrix metallopeptidase 17
Synonyms: MT4-MMP, membrane type-4 matrix metalloproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23948
HGNC: HGNC:7163
Homologene: 22669
Hey2
Name: hairy/enhancer-of-split related with YRPW motif 2
Synonyms: CHF1, Hrt2, Herp1, Hesr2, bHLHb32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15214
HGNC: HGNC:4881
Homologene: 22705
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73324
Homologene: 17569
Rb1
Name: RB transcriptional corepressor 1
Synonyms: pRb, Rb, Rb-1, retinoblastoma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Rras
Name: related RAS viral (r-ras) oncogene
Synonyms: Rras1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20130
Homologene: 4565
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9430067K09Rik, 6720411P22Rik, 9130023D20Rik, 4833412L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Ift172
Name: intraflagellar transport 172
Synonyms: wim, 4930553F24Rik, avc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67661
Homologene: 15202
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNFRrp, TNF receptor-related protein, LT-beta receptor, LT beta-R, Tnfbr, Ltar, TNF-R-III, TNFCR, TNFR2-RP, LTbetaR, Tnfrsf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Nacc2
Name: nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
Synonyms: 0610020I02Rik, C030048H19Rik, Btbd14a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67991
Homologene: 75239
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69239
Homologene: 130756
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Or8b12b
Name: olfactory receptor family 8 subfamily B member 12B
Synonyms: GA_x6K02T2PVTD-31458511-31459443, MOR161-4, Olfr875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258744
Homologene: 121527
Krtcap3
Name: keratinocyte associated protein 3
Synonyms: 2010001C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69815
Homologene: 12332
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: mGluR3, 0710001G23Rik, Gprc1c, mGlu3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Gm8909
Name: predicted gene 8909
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 667977
Homologene: 128352
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Klf11
Name: Kruppel-like factor 11
Synonyms: Tieg2b, D12Ertd427e, Tieg2, Tieg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 194655
Homologene: 2668
Gmppb
Name: GDP-mannose pyrophosphorylase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 331026
Homologene: 5578
9530002B09Rik
Name: RIKEN cDNA 9530002B09 gene
Synonyms: Vpp1, Aump
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77432
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Otop2
Name: otopetrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237987
Homologene: 27803
Spata9
Name: spermatogenesis associated 9
Synonyms: 4930599C08Rik, 1700030K01Rik, A930023H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75571
VEGA: 13
Homologene: 12609
Tas2r115
Name: taste receptor, type 2, member 115
Synonyms: Tas2r15, mGR15, mt2r49, T2R15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353325
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665186
Homologene: 104039
Ccdc173
Name: coiled-coil domain containing 173
Synonyms: 4930525K21Rik, 4930578N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75051
Homologene: 18989
Aadacl4fm5
Name: AADACL4 family member 5
Synonyms: LOC329993, Gm438
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329993
Homologene: 135765
Fut2
Name: fucosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14344
HGNC: HGNC:4013
Homologene: 10325
Amh
Name: anti-Mullerian hormone
Synonyms: MIS, Mullerian inhibiting substance
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11705
VEGA: 10
HGNC: HGNC:464
Homologene: 68060
Or5k8
Name: olfactory receptor family 5 subfamily K member 8
Synonyms: GA_x54KRFPKG5P-55026345-55025418, GA_x54KRFPKG5P-54993816-54992890, MOR184-10P, MOR184-1, Olfr174, Olfr175, Olfr175-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259004
Homologene: 17461
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: 1810041F13Rik, Pdipl, Pdip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69191
Homologene: 55994
Rnf8
Name: ring finger protein 8
Synonyms: AIP37, 3830404E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58230
Homologene: 2944
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 66,506,669 bp
  • T to A, chromosome 2 at 26,089,590 bp
  • T to A, chromosome 2 at 26,991,334 bp
  • G to A, chromosome 2 at 69,670,210 bp
  • C to A, chromosome 2 at 69,789,441 bp
  • T to C, chromosome 2 at 76,798,893 bp
  • G to A, chromosome 2 at 165,070,741 bp
  • A to T, chromosome 3 at 93,203,584 bp
  • A to T, chromosome 4 at 122,702,335 bp
  • T to C, chromosome 4 at 134,202,518 bp
  • T to C, chromosome 4 at 136,555,298 bp
  • T to A, chromosome 4 at 144,777,415 bp
  • C to A, chromosome 5 at 9,570,048 bp
  • T to C, chromosome 5 at 31,251,803 bp
  • A to G, chromosome 5 at 31,275,842 bp
  • T to G, chromosome 5 at 129,598,670 bp
  • A to C, chromosome 6 at 125,313,388 bp
  • T to C, chromosome 6 at 132,737,959 bp
  • T to G, chromosome 7 at 45,020,556 bp
  • T to A, chromosome 7 at 45,651,274 bp
  • C to T, chromosome 8 at 54,693,096 bp
  • T to C, chromosome 8 at 57,552,430 bp
  • T to A, chromosome 9 at 37,773,331 bp
  • A to T, chromosome 9 at 108,049,797 bp
  • G to A, chromosome 10 at 30,840,489 bp
  • C to T, chromosome 10 at 41,451,997 bp
  • A to G, chromosome 10 at 80,806,176 bp
  • A to G, chromosome 10 at 107,710,627 bp
  • A to C, chromosome 11 at 29,561,366 bp
  • C to T, chromosome 11 at 115,329,462 bp
  • C to G, chromosome 12 at 24,655,090 bp
  • C to A, chromosome 12 at 75,137,673 bp
  • T to C, chromosome 13 at 75,977,779 bp
  • A to T, chromosome 13 at 112,714,198 bp
  • T to C, chromosome 14 at 49,682,686 bp
  • A to T, chromosome 14 at 73,211,712 bp
  • A to T, chromosome 16 at 58,824,155 bp
  • T to C, chromosome 17 at 26,196,243 bp
  • T to C, chromosome 17 at 29,621,639 bp
  • A to G, chromosome 17 at 35,509,477 bp
  • G to T, chromosome 17 at 36,168,057 bp
  • C to T, chromosome 17 at 58,922,727 bp
  • G to A, chromosome 17 at 63,356,851 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0553 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038745-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.