MMRRC:038747-MU

Synonyms: Gnas1, Gs-alpha, Gs alpha, G alpha s, Nesp55, P2, P3, P1, neuroendocrine-specific Golgi protein p55 isoform 1, XLalphas, Gsa, Nesp, Gnasxl, Nespl, Oedsml, Galphas, SCG6

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 2

MGI: MGI:95777

NCBI: 14683

Ensembl: ENSMUSG00000027523

VEGA: OTTMUSG00000016388

HGNC: HGNC:4392

Homologene: 55534

CCDS: CCDS17149.1, CCDS17150.1, CCDS17151.1, CCDS38354.1, CCDS38355.1, CCDS38356.1, CCDS38357.1, CCDS50817.1, CCDS89590.1, CCDS89591.1

UCSC: Chr2:174126113-174188537

AC111097.1

Name:

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 3

Gimap1

Name: GTPase, IMAP family member 1

Synonyms: IAP38, imap, 38kDa, Imap38

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 6

MGI: MGI:109368

NCBI: 16205

Ensembl: ENSMUSG00000090019

VEGA: OTTMUSG00000026921

HGNC: HGNC:23237

Homologene: 7379

CCDS: CCDS20113.1

UCSC: Chr6:48715981-48720729

Ffar3

Name: free fatty acid receptor 3

Synonyms: LOC233080, Gpr41

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 7

MGI: MGI:2685324

NCBI: 233080

Ensembl: ENSMUSG00000019429

VEGA: OTTMUSG00000049768

HGNC: HGNC:4500|HGNC:4499

Homologene: 82482

CCDS: CCDS21112.1

UCSC: Chr7:30553755-30555603

Ears2

Name: glutamyl-tRNA synthetase 2, mitochondrial

Synonyms: 3230401I01Rik

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 7

MGI: MGI:1914667

NCBI: 67417

Ensembl: ENSMUSG00000030871

VEGA: OTTMUSG00000025467

HGNC: HGNC:29419

Homologene: 6907

CCDS: CCDS21807.1

UCSC: Chr7:121633385-121666436

Trcg1

Name: taste receptor cell gene 1

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 9

MGI: MGI:3576664

NCBI: 541610

Ensembl: ENSMUSG00000070298

VEGA: OTTMUSG00000061751

Homologene: 134171

CCDS: CCDS23218.1

UCSC: Chr9:57143839-57157147

Or6c2

Name: olfactory receptor family 6 subfamily C member 2

Synonyms: GA_x6K02T2PULF-11205096-11206034, MOR114-1, Olfr791

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 10

MGI: MGI:3030625

NCBI: 258932

Ensembl: ENSMUSG00000047626

VEGA: OTTMUSG00000056572

HGNC: HGNC:15436

Homologene: 71950

CCDS: CCDS24321.1

UCSC: Chr10:129362098-129363036

Hecw1

Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Synonyms: NEDL1, E130207I19Rik

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 13

MGI: MGI:2444115

NCBI: 94253

Ensembl: ENSMUSG00000021301

VEGA: 13

HGNC: HGNC:22195

Homologene: 9004

CCDS: CCDS49207.1

UCSC: Chr13:14401023-14697874

Prl7d1

Name: prolactin family 7, subfamily d, member 1

Synonyms: PRP, PLF-RP, Plfr

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 13

MGI: MGI:97619

NCBI: 18814

Ensembl: ENSMUSG00000021348

VEGA: OTTMUSG00000000648

HGNC: HGNC:9445

Homologene: 7894

CCDS: CCDS26405.1, CCDS88432.1

UCSC: Chr13:27892981-27900720

Wnt10b

Name: wingless-type MMTV integration site family, member 10B

Synonyms: Wnt12

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 15

MGI: MGI:108061

NCBI: 22410

Ensembl: ENSMUSG00000022996

VEGA: 15

HGNC: HGNC:12775

Homologene: 20721

CCDS: CCDS27806.1

UCSC: Chr15:98668593-98676093

Gm17657

Name: predicted gene, 17657

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 17

MGI: MGI:4937291

Ensembl: ENSMUSG00000091614

Homologene: 141016

H2-M10.5

Name: histocompatibility 2, M region locus 10.5

Synonyms: 6.9H

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 17

MGI: MGI:1276526

NCBI: 224761

Ensembl: ENSMUSG00000037246

VEGA: OTTMUSG00000037372

HGNC: HGNC:4963|HGNC:4964|HGNC:4962

Homologene: 117973

CCDS: CCDS28725.1

UCSC: Chr17:37083802-37087127

Hoga1

Name: 4-hydroxy-2-oxoglutarate aldolase 1

Synonyms: 0610010D20Rik, Npl2, Dhdpsl

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 19

MGI: MGI:1914682

NCBI: 67432

Ensembl: ENSMUSG00000025176

VEGA: OTTMUSG00000035806

HGNC: HGNC:25155

Homologene: 12130

CCDS: CCDS29820.1

UCSC: Chr19:42033998-42060128

Mrpl43

Name: mitochondrial ribosomal protein L43

Synonyms: bMRP36a, 4930442D21Rik

Type: Gene

Species: Mus musculus (mouse)

Chromosome: 19

MGI: MGI:2137229

NCBI: 94067

Ensembl: ENSMUSG00000025208

VEGA: 19

HGNC: HGNC:14517

Homologene: 41847

CCDS: CCDS38000.1

UCSC: Chr19:44993453-44994881

Heph

Name: hephaestin

Synonyms: sla, sex linked anemia, C130006F04Rik, Cpl

Type: Gene

Species: Mus musculus (mouse)

Chromosome: X

MGI: MGI:1332240

NCBI: 15203

Ensembl: ENSMUSG00000031209

VEGA: OTTMUSG00000018531

HGNC: HGNC:4866

Homologene: 32094

CCDS: CCDS30289.1, CCDS30290.1

UCSC: ChrX:95499042-95618091

Foxo4

Name: forkhead box O4

Synonyms: afx, Foxo4, Afxh, Mllt7

Type: Gene

Species: Mus musculus (mouse)

Chromosome: X

MGI: MGI:1891915

NCBI: 54601

Ensembl: ENSMUSG00000042903

VEGA: OTTMUSG00000018205

HGNC: HGNC:7139

Homologene: 4342

CCDS: CCDS41077.1

UCSC: ChrX:100297855-100304479

Genetic Alterations

ENU-induced transitions at the following base pair locations (GRCm38):

A to G, chromosome 1 at 74,688,280 bp
G to T, chromosome 1 at 93,624,591 bp
G to A, chromosome 2 at 31,608,137 bp
AAAAGAAGAGGAAAGAAGAGGAAAG to AAAAGAAGAGGAAAG, chromosome 2 at 71,214,518 bp
T to C, chromosome 2 at 89,844,443 bp
T to C, chromosome 2 at 153,417,684 bp
G to A, chromosome 2 at 172,367,147 bp
A to G, chromosome 2 at 174,298,511 bp
A to G, chromosome 3 at 32,736,693 bp
A to G, chromosome 3 at 53,516,860 bp
T to C, chromosome 3 at 54,302,090 bp
A to T, chromosome 3 at 79,605,805 bp
T to G, chromosome 3 at 87,814,437 bp
G to C, chromosome 3 at 92,824,357 bp
C to A, chromosome 3 at 104,004,469 bp
C to A, chromosome 3 at 107,892,345 bp
G to A, chromosome 3 at 119,431,542 bp
A to T, chromosome 3 at 129,791,296 bp
T to A, chromosome 4 at 32,640,381 bp
T to C, chromosome 4 at 34,807,194 bp
C to A, chromosome 4 at 41,625,335 bp
C to A, chromosome 4 at 43,569,927 bp
A to G, chromosome 4 at 45,458,321 bp
T to A, chromosome 4 at 58,128,858 bp
T to A, chromosome 4 at 152,107,469 bp
A to G, chromosome 5 at 3,606,130 bp
T to C, chromosome 5 at 37,118,873 bp
G to A, chromosome 5 at 114,263,114 bp
T to C, chromosome 6 at 29,890,671 bp
T to C, chromosome 6 at 48,741,429 bp
A to T, chromosome 6 at 92,458,565 bp
A to T, chromosome 6 at 94,592,410 bp
A to G, chromosome 6 at 118,178,610 bp
C to T, chromosome 6 at 118,612,625 bp
T to A, chromosome 6 at 137,443,594 bp
C to T, chromosome 7 at 7,290,504 bp
G to T, chromosome 7 at 19,307,213 bp
A to C, chromosome 7 at 19,448,673 bp
A to G, chromosome 7 at 19,733,223 bp
A to T, chromosome 7 at 23,505,087 bp
G to A, chromosome 7 at 30,316,744 bp
G to T, chromosome 7 at 30,855,537 bp
A to T, chromosome 7 at 42,266,018 bp
A to T, chromosome 7 at 42,928,528 bp
A to G, chromosome 7 at 86,695,308 bp
A to G, chromosome 7 at 99,814,183 bp
T to C, chromosome 7 at 103,328,963 bp
A to G, chromosome 7 at 104,357,298 bp
T to C, chromosome 7 at 107,729,174 bp
T to C, chromosome 7 at 122,048,444 bp
C to T, chromosome 7 at 127,472,095 bp
A to T, chromosome 7 at 132,044,043 bp
T to C, chromosome 8 at 16,185,273 bp
T to C, chromosome 8 at 89,031,758 bp
A to T, chromosome 8 at 104,420,665 bp
G to T, chromosome 9 at 44,092,784 bp
T to A, chromosome 9 at 44,847,571 bp
A to T, chromosome 9 at 53,931,592 bp
C to T, chromosome 9 at 57,242,333 bp
T to C, chromosome 9 at 57,614,101 bp
T to C, chromosome 9 at 69,361,746 bp
T to C, chromosome 9 at 70,586,081 bp
T to A, chromosome 9 at 70,754,234 bp
C to A, chromosome 9 at 104,023,434 bp
T to A, chromosome 9 at 109,979,103 bp
A to C, chromosome 10 at 21,349,323 bp
A to T, chromosome 10 at 62,587,528 bp
T to C, chromosome 10 at 67,225,789 bp
T to C, chromosome 10 at 79,293,449 bp
T to C, chromosome 10 at 129,526,896 bp
T to C, chromosome 11 at 5,717,477 bp
T to A, chromosome 11 at 32,233,118 bp
T to C, chromosome 11 at 60,521,638 bp
C to A, chromosome 11 at 61,707,663 bp
G to T, chromosome 11 at 67,178,967 bp
A to T, chromosome 12 at 65,161,453 bp
A to T, chromosome 12 at 78,892,172 bp
G to T, chromosome 13 at 14,236,941 bp
A to T, chromosome 13 at 27,712,055 bp
A to G, chromosome 13 at 59,800,317 bp
A to G, chromosome 13 at 65,078,445 bp
A to G, chromosome 13 at 92,516,520 bp
A to C, chromosome 13 at 96,484,179 bp
A to T, chromosome 13 at 106,892,461 bp
T to C, chromosome 14 at 115,552,328 bp
A to G, chromosome 15 at 64,094,364 bp
A to G, chromosome 15 at 98,772,937 bp
T to A, chromosome 17 at 5,918,413 bp
C to A, chromosome 17 at 19,522,120 bp
T to C, chromosome 17 at 26,117,114 bp
A to T, chromosome 17 at 29,519,571 bp
G to A, chromosome 17 at 36,774,728 bp
T to C, chromosome 18 at 10,458,781 bp
C to T, chromosome 18 at 44,873,143 bp
A to C, chromosome 19 at 42,046,075 bp
A to T, chromosome 19 at 45,005,952 bp
A to T, chromosome X at 96,558,084 bp
A to G, chromosome X at 101,255,178 bp
A to G, chromosome X at 147,496,755 bp

Genotype Determination

Genotyping Protocol(s)
Center protocol and contact for technical support will be shipped with mice.

Strain Description [Including phenotype, strain background, strain development and suggested control mice]

Phenotype

G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.

Strain Development

C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.

Suggested Control Mice

Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary

The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Strain Origin

Donor

Bruce Beutler, M.D., University of Texas Southwestern Medical Center.

Primary Reference

MUTAGENETIX record for R0555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information Expand All

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .

Appearance

Coat Color

Black

Breeding

MMRRC Breeding System

Random intra-strain mating

Breeding Scheme(s)

When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.

Overall Breeding Performance

Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size

Undetermined

Recommended wean age

3 weeks

Order Request Information Expand All

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution [Including applicable technology transfer agreements]

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)

MMRRC Item #	Description	Distribution Fee / Unit (US $) Shipping & Handling not included	Units	Notes
038747-MU-RESUS	Litter recovered from cryo-archive	$5,475.00 / Non-Profit	Litter	Recovered litter⁴; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

¹ The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

² An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

³ An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

⁴ The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.

Strain Detail Sheet

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Colony and Husbandry Information Expand All

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