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Strain Name:
C57BL/6J-MtgxR0555Btlr/Mmmh
Stock Number:
038747-MU
Citation ID:
RRID:MMRRC_038747-MU
Other Names:
R0555 (G1), C57BL/6J-MtgxR0555Btlr
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, A330051M14Rik, Marta2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Ahcyl2
Name: S-adenosylhomocysteine hydrolase-like 2
Synonyms: 4631427C17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74340
Homologene: 69337
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76582
Homologene: 7089
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,688,280 bp
  • G to T, chromosome 1 at 93,624,591 bp
  • G to A, chromosome 2 at 31,608,137 bp
  • AAAAGAAGAGGAAAGAAGAGGAAAG to AAAAGAAGAGGAAAG, chromosome 2 at 71,214,518 bp
  • T to C, chromosome 2 at 89,844,443 bp
  • T to C, chromosome 2 at 153,417,684 bp
  • G to A, chromosome 2 at 172,367,147 bp
  • A to G, chromosome 2 at 174,298,511 bp
  • A to G, chromosome 3 at 32,736,693 bp
  • A to G, chromosome 3 at 53,516,860 bp
  • T to C, chromosome 3 at 54,302,090 bp
  • A to T, chromosome 3 at 79,605,805 bp
  • T to G, chromosome 3 at 87,814,437 bp
  • G to C, chromosome 3 at 92,824,357 bp
  • C to A, chromosome 3 at 104,004,469 bp
  • C to A, chromosome 3 at 107,892,345 bp
  • G to A, chromosome 3 at 119,431,542 bp
  • A to T, chromosome 3 at 129,791,296 bp
  • T to A, chromosome 4 at 32,640,381 bp
  • T to C, chromosome 4 at 34,807,194 bp
  • C to A, chromosome 4 at 41,625,335 bp
  • C to A, chromosome 4 at 43,569,927 bp
  • A to G, chromosome 4 at 45,458,321 bp
  • T to A, chromosome 4 at 58,128,858 bp
  • T to A, chromosome 4 at 152,107,469 bp
  • A to G, chromosome 5 at 3,606,130 bp
  • T to C, chromosome 5 at 37,118,873 bp
  • G to A, chromosome 5 at 114,263,114 bp
  • T to C, chromosome 6 at 29,890,671 bp
  • T to C, chromosome 6 at 48,741,429 bp
  • A to T, chromosome 6 at 92,458,565 bp
  • A to T, chromosome 6 at 94,592,410 bp
  • A to G, chromosome 6 at 118,178,610 bp
  • C to T, chromosome 6 at 118,612,625 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • C to T, chromosome 7 at 7,290,504 bp
  • G to T, chromosome 7 at 19,307,213 bp
  • A to C, chromosome 7 at 19,448,673 bp
  • A to G, chromosome 7 at 19,733,223 bp
  • A to T, chromosome 7 at 23,505,087 bp
  • G to A, chromosome 7 at 30,316,744 bp
  • G to T, chromosome 7 at 30,855,537 bp
  • A to T, chromosome 7 at 42,266,018 bp
  • A to T, chromosome 7 at 42,928,528 bp
  • A to G, chromosome 7 at 86,695,308 bp
  • A to G, chromosome 7 at 99,814,183 bp
  • T to C, chromosome 7 at 103,328,963 bp
  • A to G, chromosome 7 at 104,357,298 bp
  • T to C, chromosome 7 at 107,729,174 bp
  • T to C, chromosome 7 at 122,048,444 bp
  • C to T, chromosome 7 at 127,472,095 bp
  • A to T, chromosome 7 at 132,044,043 bp
  • T to C, chromosome 8 at 16,185,273 bp
  • T to C, chromosome 8 at 89,031,758 bp
  • A to T, chromosome 8 at 104,420,665 bp
  • G to T, chromosome 9 at 44,092,784 bp
  • T to A, chromosome 9 at 44,847,571 bp
  • A to T, chromosome 9 at 53,931,592 bp
  • C to T, chromosome 9 at 57,242,333 bp
  • T to C, chromosome 9 at 57,614,101 bp
  • T to C, chromosome 9 at 69,361,746 bp
  • T to C, chromosome 9 at 70,586,081 bp
  • T to A, chromosome 9 at 70,754,234 bp
  • C to A, chromosome 9 at 104,023,434 bp
  • T to A, chromosome 9 at 109,979,103 bp
  • A to C, chromosome 10 at 21,349,323 bp
  • A to T, chromosome 10 at 62,587,528 bp
  • T to C, chromosome 10 at 67,225,789 bp
  • T to C, chromosome 10 at 79,293,449 bp
  • T to C, chromosome 10 at 129,526,896 bp
  • T to C, chromosome 11 at 5,717,477 bp
  • T to A, chromosome 11 at 32,233,118 bp
  • T to C, chromosome 11 at 60,521,638 bp
  • C to A, chromosome 11 at 61,707,663 bp
  • G to T, chromosome 11 at 67,178,967 bp
  • A to T, chromosome 12 at 65,161,453 bp
  • A to T, chromosome 12 at 78,892,172 bp
  • G to T, chromosome 13 at 14,236,941 bp
  • A to T, chromosome 13 at 27,712,055 bp
  • A to G, chromosome 13 at 59,800,317 bp
  • A to G, chromosome 13 at 65,078,445 bp
  • A to G, chromosome 13 at 92,516,520 bp
  • A to C, chromosome 13 at 96,484,179 bp
  • A to T, chromosome 13 at 106,892,461 bp
  • T to C, chromosome 14 at 115,552,328 bp
  • A to G, chromosome 15 at 64,094,364 bp
  • A to G, chromosome 15 at 98,772,937 bp
  • T to A, chromosome 17 at 5,918,413 bp
  • C to A, chromosome 17 at 19,522,120 bp
  • T to C, chromosome 17 at 26,117,114 bp
  • A to T, chromosome 17 at 29,519,571 bp
  • G to A, chromosome 17 at 36,774,728 bp
  • T to C, chromosome 18 at 10,458,781 bp
  • C to T, chromosome 18 at 44,873,143 bp
  • A to C, chromosome 19 at 42,046,075 bp
  • A to T, chromosome 19 at 45,005,952 bp
  • A to T, chromosome X at 96,558,084 bp
  • A to G, chromosome X at 101,255,178 bp
  • A to G, chromosome X at 147,496,755 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.