Strain Name:
C57BL/6J-MtgxR0579Btlr/Mmmh
Stock Number:
038769-MU
Citation ID:
RRID:MMRRC_038769-MU
Other Names:
R0579 (G1), C57BL/6J-MtgxR0579Btlr
Major Collection:

Gene Information

Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20512
Homologene: 20882
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Il21
Name: interleukin 21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 60505
HGNC: HGNC:6005
Homologene: 11032
Timmdc1
Name: translocase of inner mitochondrial membrane domain containing 1
Synonyms: 2810021C21Rik, 4930455C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76916
HGNC: HGNC:1321
Homologene: 9578
Cep83
Name: centrosomal protein 83
Synonyms: 2600001G24Rik, 5730513H21Rik, 4921537D05Rik, Ccdc41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77048
VEGA: 10
Homologene: 9396
F2r
Name: coagulation factor II (thrombin) receptor
Synonyms: thrombin receptor, Par1, Cf2r, ThrR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14062
VEGA: 13
HGNC: HGNC:3537
Homologene: 1510
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: 2310079H06Rik, D030051N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228361
Homologene: 18204
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 212127
Homologene: 13463
L2hgdh
Name: L-2-hydroxyglutarate dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217666
VEGA: 12
Homologene: 11767
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67724
Homologene: 41000
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Ptprj
Name: protein tyrosine phosphatase, receptor type, J
Synonyms: Byp, DEP-1, Scc-1, Scc1, CD148, RPTPJ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 326622
Homologene: 6101
Pafah1b2
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
Synonyms: mus[b], Pafahb, PAF-AH 30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18475
VEGA: 9
HGNC: HGNC:8575
Homologene: 1932
Abcf3
Name: ATP-binding cassette, sub-family F (GCN20), member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27406
HGNC: HGNC:72
Homologene: 22784
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Slc25a22
Name: solute carrier family 25 (mitochondrial carrier, glutamate), member 22
Synonyms: 1300006L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68267
Homologene: 69383
Acr
Name: acrosin prepropeptide
Synonyms: preproacrosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11434
VEGA: 15
HGNC: HGNC:126
Homologene: 855
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22324
Homologene: 3961
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Npy4r
Name: neuropeptide Y receptor Y4
Synonyms: NYYR-D, Y4, Ppyr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19065
VEGA: 14
HGNC: HGNC:9329
Homologene: 38119
Tppp
Name: tubulin polymerization promoting protein
Synonyms: 2900041A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72948
Homologene: 21389
Or12d17
Name: olfactory receptor family 12 subfamily D member 17
Synonyms: MOR250-1, GA_x6K02T2PSCP-1914078-1915022, Olfr109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258832
Homologene: 12811
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117229
Homologene: 75307
Stard7
Name: START domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99138
Homologene: 32463
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230806
Homologene: 19232
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Gm19345
Name: predicted gene, 19345
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100502736
Itpripl1
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 1
Synonyms: 1700041B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73338
Homologene: 77641
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp-alpha, Rnh2, Nalp4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Or6c1
Name: olfactory receptor family 6 subfamily C member 1
Synonyms: GA_x6K02T2PULF-11361362-11360424, MOR111-1, Olfr802
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258934
HGNC: HGNC:8355
Homologene: 105151
4921517D22Rik
Name: RIKEN cDNA 4921517D22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70900
VEGA: 13
Homologene: 87278
AC238840.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Glt28d2
Name: glycosyltransferase 28 domain containing 2
Synonyms: 4732486J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320302
Homologene: 44843
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Ifna9
Name: interferon alpha 9
Synonyms: Ifa9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15972
Homologene: 68536
Cd300ld2
Name: CD300 molecule like family member D2
Synonyms: Gm11709
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 629970
Flot1
Name: flotillin 1
Synonyms: reggie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14251
HGNC: HGNC:3757
Homologene: 31337
Or2h2c
Name: olfactory receptor family 2 subfamily H member 2C
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128, Olfr92
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8252
Homologene: 115562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 68,042,462 bp
  • T to A, chromosome 1 at 181,744,747 bp
  • A to T, chromosome 2 at 5,988,429 bp
  • C to A, chromosome 2 at 90,436,569 bp
  • A to G, chromosome 2 at 91,824,465 bp
  • G to T, chromosome 2 at 127,141,091 bp
  • T to C, chromosome 2 at 127,284,553 bp
  • T to G, chromosome 3 at 37,227,774 bp
  • A to G, chromosome 3 at 53,467,151 bp
  • G to A, chromosome 3 at 85,872,133 bp
  • A to T, chromosome 3 at 98,290,948 bp
  • G to A, chromosome 4 at 41,393,706 bp
  • T to A, chromosome 4 at 88,592,271 bp
  • T to A, chromosome 4 at 134,072,738 bp
  • A to G, chromosome 5 at 104,974,103 bp
  • A to G, chromosome 5 at 107,821,709 bp
  • T to A, chromosome 7 at 6,060,845 bp
  • A to G, chromosome 7 at 19,854,976 bp
  • C to A, chromosome 7 at 38,448,275 bp
  • C to T, chromosome 7 at 109,325,697 bp
  • T to C, chromosome 7 at 141,431,359 bp
  • T to C, chromosome 9 at 45,968,713 bp
  • A to G, chromosome 10 at 94,749,053 bp
  • A to T, chromosome 10 at 129,682,237 bp
  • A to G, chromosome 11 at 115,012,299 bp
  • A to T, chromosome 12 at 69,701,272 bp
  • GCC to GC, chromosome 13 at 59,691,598 bp
  • T to C, chromosome 13 at 74,021,233 bp
  • A to G, chromosome 13 at 95,618,349 bp
  • G to A, chromosome 14 at 34,146,683 bp
  • T to A, chromosome 15 at 8,688,309 bp
  • T to A, chromosome 15 at 34,509,969 bp
  • C to G, chromosome 15 at 89,569,475 bp
  • G to A, chromosome 16 at 20,550,648 bp
  • A to G, chromosome 16 at 38,522,383 bp
  • C to A, chromosome 17 at 35,831,008 bp
  • G to C, chromosome 17 at 37,111,455 bp
  • T to C, chromosome 17 at 37,466,347 bp
  • G to T, chromosome 17 at 57,279,271 bp
  • A to T, chromosome 19 at 33,746,898 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0579 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.