Strain Name:
C57BL/6J-MtgxR0581Btlr/Mmmh
Stock Number:
038771-MU
Citation ID:
RRID:MMRRC_038771-MU
Other Names:
R0581 (G1), C57BL/6J-MtgxR0581Btlr
Major Collection:

Gene Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Sparcl1
Name: SPARC-like 1
Synonyms: Sc1, hevin, mast9, Ecm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13602
Homologene: 3438
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, MYH-beta/slow, beta-MHC, B-MHC, MyHC-I, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228850
Homologene: 10666
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Nemf
Name: nuclear export mediator factor
Synonyms: 4933405E14Rik, 1500011I12Rik, Sdccag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Gpr68
Name: G protein-coupled receptor 68
Synonyms: OGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238377
HGNC: HGNC:4519
Homologene: 2603
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, TFIIIC-BETA, TFIIIC110, 1300004C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Pkp2
Name: plakophilin 2
Synonyms: 1200012P04Rik, 1200008D14Rik, Pkp2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16532
Homologene: 7392
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58178
Homologene: 10967
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68054
Homologene: 23588
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210045
Homologene: 65242
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234353
Homologene: 87257
Olfr344
Name: olfactory receptor 344
Synonyms: GA_x6K02T2NLDC-33262744-33263673, MOR136-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258621
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Ggn
Name: gametogenetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243897
Homologene: 45139
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Stat6
Name: signal transducer and activator of transcription 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20852
Homologene: 2373
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 665119
VEGA: 16
Homologene: 96163
Psmb4
Name: proteasome (prosome, macropain) subunit, beta type 4
Synonyms: Pros-27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19172
HGNC: HGNC:9541
Homologene: 2090
Olfr123
Name: olfactory receptor 123
Synonyms: MOR256-9, GA_x6K02T2PSCP-2255106-2256035
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258623
Homologene: 105169
Tat
Name: tyrosine aminotransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234724
Homologene: 37293
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Dpp-4, Cd26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57745
Homologene: 49338
AC238840.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Yipf7
Name: Yip1 domain family, member 7
Synonyms: Yip1b, 2310016N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75581
Homologene: 69367
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381823
Homologene: 12781
AC171210.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Krt222
Name: keratin 222
Synonyms: 6330509G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268481
Homologene: 17556
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, Il-2Rbeta, IL15Rbeta, IL-2/15Rbeta, IL-15 receptor beta chain, IL-15Rbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GT to GTT, chromosome 1 at 88,256,166 bp
  • C to T, chromosome 1 at 107,546,962 bp
  • T to C, chromosome 2 at 36,568,822 bp
  • T to A, chromosome 2 at 62,356,676 bp
  • A to G, chromosome 2 at 158,492,961 bp
  • T to C, chromosome 3 at 94,886,168 bp
  • A to G, chromosome 5 at 4,050,620 bp
  • G to T, chromosome 5 at 31,159,518 bp
  • T to A, chromosome 5 at 69,521,063 bp
  • T to C, chromosome 5 at 104,093,312 bp
  • G to A, chromosome 6 at 134,983,813 bp
  • T to C, chromosome 7 at 10,714,530 bp
  • T to A, chromosome 7 at 24,125,863 bp
  • T to A, chromosome 7 at 28,757,026 bp
  • A to G, chromosome 7 at 29,172,304 bp
  • C to A, chromosome 7 at 38,448,275 bp
  • A to G, chromosome 8 at 25,710,691 bp
  • T to A, chromosome 8 at 25,937,501 bp
  • T to C, chromosome 8 at 67,720,946 bp
  • A to T, chromosome 8 at 84,601,936 bp
  • A to G, chromosome 8 at 109,991,638 bp
  • A to G, chromosome 10 at 7,702,941 bp
  • A to G, chromosome 10 at 63,162,244 bp
  • G to A, chromosome 10 at 107,789,040 bp
  • A to T, chromosome 10 at 127,648,116 bp
  • A to G, chromosome 11 at 72,851,900 bp
  • G to A, chromosome 11 at 99,236,192 bp
  • T to A, chromosome 11 at 116,229,490 bp
  • A to T, chromosome 12 at 69,322,271 bp
  • G to C, chromosome 12 at 100,878,556 bp
  • T to A, chromosome 12 at 104,031,140 bp
  • T to C, chromosome 14 at 54,985,496 bp
  • A to G, chromosome 15 at 3,388,634 bp
  • T to A, chromosome 15 at 11,851,450 bp
  • T to C, chromosome 15 at 58,126,664 bp
  • T to A, chromosome 15 at 78,481,936 bp
  • T to A, chromosome 16 at 5,178,485 bp
  • T to A, chromosome 16 at 16,269,783 bp
  • A to G, chromosome 17 at 37,796,102 bp
  • T to A, chromosome 19 at 40,047,555 bp
  • T to A, chromosome 19 at 50,252,701 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0581 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038771-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.