Strain Name:
C57BL/6J-MtgxR0587Btlr/Mmmh
Stock Number:
038777-MU
Citation ID:
RRID:MMRRC_038777-MU
Other Names:
R0587 (G1), C57BL/6J-MtgxR0587Btlr
Major Collection:

Strain Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: PRCE, separase, SSE, ESP1, PRCE, Cerp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54524
Homologene: 10301
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57138
Homologene: 10665
2310061I04Rik
Name: RIKEN cDNA 2310061I04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69662
Homologene: 17027
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Ak2
Name: adenylate kinase 2
Synonyms: Ak-2, D4Ertd220e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11637
HGNC: HGNC:362
Homologene: 1227
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E1B-AP5, E1BAP5, E130317O14Rik, Hnrnpul, Hnrpul1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232989
Homologene: 31419
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 6030402H20Rik, 2610019A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72149
Homologene: 12448
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72201
Homologene: 6064
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Ctsc
Name: cathepsin C
Synonyms: DPP1, dipeptidylpeptidase 1, DPPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13032
HGNC: HGNC:2528
Homologene: 1373
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Tbx1
Name: T-box 1
Synonyms: nmf219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21380
VEGA: 16
Homologene: 7966
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71355
Homologene: 65061
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Fcsk
Name: fucose kinase
Synonyms: L-fucose kinase, 1110046B12Rik, Fuk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234730
Homologene: 15452
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Png-1, Nztf1, Pmng1, C630034G21Rik, 2900093J19Rik, 2900046C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Ankrd60
Name: ankyrin repeat domain 60
Synonyms: 1700019A24Rik, 1700030G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70065
Homologene: 43792
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, myr2, C80397, mm1beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Tmem143
Name: transmembrane protein 143
Synonyms: 2310076O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70209
Homologene: 10105
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: fg, BPFD#36, froggy, enr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242248
Homologene: 9926
Ctsf
Name: cathepsin F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56464
VEGA: 19
HGNC: HGNC:2531
Homologene: 31194
Or4c12
Name: olfactory receptor family 4 subfamily C member 12
Synonyms: GA_x6K02T2Q125-51376062-51375133, MOR232-9, Olfr1259
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258338
Homologene: 128115
Pak3
Name: p21 (RAC1) activated kinase 3
Synonyms: PAK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 18481
HGNC: HGNC:8592
Homologene: 55664
Spatc1l
Name: spermatogenesis and centriole associated 1 like
Synonyms: 1700022B01Rik, 1700027D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76573
HGNC: HGNC:1298
Homologene: 75292
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 89,943,392 bp
  • A to G, chromosome 2 at 91,146,885 bp
  • G to A, chromosome 2 at 164,976,533 bp
  • T to A, chromosome 2 at 173,568,851 bp
  • C to A, chromosome 3 at 87,978,569 bp
  • A to G, chromosome 3 at 103,625,571 bp
  • A to G, chromosome 3 at 136,214,037 bp
  • T to C, chromosome 3 at 145,293,145 bp
  • T to C, chromosome 4 at 14,815,661 bp
  • A to G, chromosome 4 at 53,107,035 bp
  • A to G, chromosome 4 at 129,002,378 bp
  • G to A, chromosome 5 at 41,821,637 bp
  • T to A, chromosome 7 at 25,745,232 bp
  • T to C, chromosome 7 at 45,907,054 bp
  • T to A, chromosome 7 at 88,297,229 bp
  • G to T, chromosome 8 at 41,286,051 bp
  • T to C, chromosome 8 at 72,859,333 bp
  • T to A, chromosome 8 at 110,883,325 bp
  • C to A, chromosome 9 at 41,984,506 bp
  • A to T, chromosome 9 at 44,847,534 bp
  • A to G, chromosome 10 at 76,564,177 bp
  • A to G, chromosome 11 at 75,657,790 bp
  • A to C, chromosome 11 at 106,170,964 bp
  • T to G, chromosome 11 at 110,311,377 bp
  • G to A, chromosome 12 at 29,811,635 bp
  • C to T, chromosome 12 at 85,266,419 bp
  • A to G, chromosome 15 at 102,303,947 bp
  • C to T, chromosome 16 at 18,583,493 bp
  • T to C, chromosome 17 at 35,892,963 bp
  • A to T, chromosome 18 at 49,935,307 bp
  • A to G, chromosome 18 at 63,022,426 bp
  • C to A, chromosome 18 at 67,623,175 bp
  • A to G, chromosome 19 at 4,855,738 bp
  • TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC to TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome X at 143,743,893 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0587 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.