Strain Name:
C57BL/6J-MtgxR0615Btlr/Mmmh
Stock Number:
038804-MU
Citation ID:
RRID:MMRRC_038804-MU
Other Names:
R0615 (G1), C57BL/6J-MtgxR0615Btlr
Major Collection:

Gene Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Wnt-3, Int-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22415
Homologene: 22527
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214968
Homologene: 16195
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2600016M12Rik, 2810470K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243272
Homologene: 10055
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27103
Homologene: 40891
Plekhf2
Name: pleckstrin homology domain containing, family F (with FYVE domain) member 2
Synonyms: ZFYVE18, 1110070J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71801
Homologene: 11620
Tpd52l2
Name: tumor protein D52-like 2
Synonyms: D54, 2810411G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66314
Homologene: 2469
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 2700059M06Rik, BRFU, TFIIIB50, 5730512K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66653
Homologene: 10127
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: E430025L02Rik, Lrrc33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224109
Homologene: 17134
Serf2
Name: small EDRK-rich factor 2
Synonyms: 4F5rel (4F5 related), m4F5rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 378702
Homologene: 85994
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, Bromi, D630037F22Rik, b2b2284Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Acaa2
Name: acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Synonyms: 0610011L04Rik, D18Ertd240e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 52538
VEGA: 18
HGNC: HGNC:83
Homologene: 4456
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, Clc1, NMF355, nmf355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: aldosterone receptor, Mlr, MR, mineralocorticoid receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 8430417G19Rik, 2610018O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 114615
Homologene: 10272
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27222
Homologene: 113769
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Fam214a
Name: family with sequence similarity 214, member A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70737
Homologene: 41394
Morn2
Name: MORN repeat containing 2
Synonyms: Mopt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 378462
VEGA: 17
Homologene: 45667
Bckdha
Name: branched chain ketoacid dehydrogenase E1, alpha polypeptide
Synonyms: BCKAD E1[a]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12039
HGNC: HGNC:986
Homologene: 569
Qprt
Name: quinolinate phosphoribosyltransferase
Synonyms: QPRTase, nicotinate-nucleotide pyrophosphorylase, 2410027J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67375
HGNC: HGNC:9755
Homologene: 8623
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 1110069I04Rik, 9530006G20Rik, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
Matn3
Name: matrilin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17182
HGNC: HGNC:6909
Homologene: 1785
Ppox
Name: protoporphyrinogen oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19044
HGNC: HGNC:9280
Homologene: 262
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76132
Homologene: 32781
Tufm
Name: Tu translation elongation factor, mitochondrial
Synonyms: EF-TuMT, 2300002G02Rik, C76308
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233870
Homologene: 2490
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76426
Homologene: 19218
Fam20c
Name: FAM20C, golgi associated secretory pathway kinase
Synonyms: DMP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80752
Homologene: 56879
Ahsg
Name: alpha-2-HS-glycoprotein
Synonyms: fetuin-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11625
VEGA: 16
HGNC: HGNC:349
Homologene: 1225
Aurkc
Name: aurora kinase C
Synonyms: AIK3, AIE1, Stk13, IAK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20871
Homologene: 68302
Olfr1297
Name: olfactory receptor 1297
Synonyms: GA_x6K02T2Q125-72673494-72672556, MOR248-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258890
Homologene: 115545
Cdk9
Name: cyclin-dependent kinase 9 (CDC2-related kinase)
Synonyms: PITALRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107951
HGNC: HGNC:1780
Homologene: 55566
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627479
Homologene: 129606
Foxj1
Name: forkhead box J1
Synonyms: Hfh4, FKHL-13, HFH-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15223
HGNC: HGNC:3816
Homologene: 1117
Terf2
Name: telomeric repeat binding factor 2
Synonyms: TRF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21750
Homologene: 4133
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216622
Tprn
Name: taperin
Synonyms: C430004E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 97031
Homologene: 52156
AC238840.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Olfr92
Name: olfactory receptor 92
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Commd2
Name: COMM domain containing 2
Synonyms: 1190017G07Rik, HSPC042, D3Ertd176e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 52245
Homologene: 9381
Mmd2
Name: monocyte to macrophage differentiation-associated 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75104
Homologene: 18425
Scx
Name: scleraxis
Synonyms: Scl, bHLHa41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20289
VEGA: 15
Homologene: 85195
Zfp474
Name: zinc finger protein 474
Synonyms: 4933409D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66758
Homologene: 12027
4933411K16Rik
Name: RIKEN cDNA 4933411K16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66765
Homologene: 83936
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 139,487,289 bp
  • A to G, chromosome 1 at 171,277,814 bp
  • A to T, chromosome 1 at 172,232,060 bp
  • C to T, chromosome 2 at 13,360,252 bp
  • A to G, chromosome 2 at 25,264,198 bp
  • C to A, chromosome 2 at 32,709,801 bp
  • C to T, chromosome 2 at 111,621,919 bp
  • C to T, chromosome 2 at 118,436,185 bp
  • T to C, chromosome 2 at 121,450,855 bp
  • T to C, chromosome 2 at 124,654,135 bp
  • T to C, chromosome 2 at 172,474,133 bp
  • A to G, chromosome 2 at 181,501,951 bp
  • A to T, chromosome 3 at 57,646,695 bp
  • A to C, chromosome 3 at 94,770,714 bp
  • A to T, chromosome 3 at 123,117,287 bp
  • C to T, chromosome 4 at 10,991,330 bp
  • C to T, chromosome 4 at 21,958,608 bp
  • A to G, chromosome 5 at 22,010,150 bp
  • A to G, chromosome 5 at 108,799,329 bp
  • T to C, chromosome 5 at 124,410,139 bp
  • A to T, chromosome 5 at 137,468,431 bp
  • G to A, chromosome 5 at 138,807,486 bp
  • A to T, chromosome 5 at 142,564,913 bp
  • G to A, chromosome 6 at 42,305,575 bp
  • A to T, chromosome 7 at 7,002,403 bp
  • G to T, chromosome 7 at 25,641,785 bp
  • C to A, chromosome 7 at 38,448,275 bp
  • G to T, chromosome 7 at 126,487,482 bp
  • T to A, chromosome 7 at 127,109,076 bp
  • A to T, chromosome 7 at 130,513,833 bp
  • C to T, chromosome 8 at 27,124,031 bp
  • A to C, chromosome 8 at 77,185,889 bp
  • G to A, chromosome 8 at 107,082,990 bp
  • T to A, chromosome 9 at 75,004,288 bp
  • C to A, chromosome 10 at 56,224,640 bp
  • A to G, chromosome 10 at 116,498,236 bp
  • A to G, chromosome 11 at 9,256,197 bp
  • C to A, chromosome 11 at 29,824,515 bp
  • T to C, chromosome 11 at 103,812,381 bp
  • T to C, chromosome 11 at 116,334,082 bp
  • T to G, chromosome 12 at 8,963,594 bp
  • C to T, chromosome 13 at 59,128,186 bp
  • T to C, chromosome 14 at 78,908,150 bp
  • T to A, chromosome 14 at 101,876,859 bp
  • C to T, chromosome 15 at 76,458,095 bp
  • A to T, chromosome 16 at 22,899,055 bp
  • C to A, chromosome 16 at 32,144,085 bp
  • G to C, chromosome 17 at 37,111,455 bp
  • A to T, chromosome 17 at 80,295,597 bp
  • C to T, chromosome 18 at 52,638,349 bp
  • A to T, chromosome 18 at 73,738,883 bp
  • G to T, chromosome 18 at 74,798,446 bp
  • T to C, chromosome 19 at 42,052,523 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0615 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038804-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.