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Strain Name:
C57BL/6J-MtgxR0617Btlr/Mmmh
Stock Number:
038806-MU
Citation ID:
RRID:MMRRC_038806-MU
Other Names:
R0617 (G1), C57BL/6J-MtgxR0617Btlr
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,248,790 bp
  • A to T, chromosome 1 at 34,500,198 bp
  • G to A, chromosome 1 at 60,281,832 bp
  • A to G, chromosome 1 at 63,543,147 bp
  • T to A, chromosome 1 at 75,532,288 bp
  • A to T, chromosome 1 at 134,328,780 bp
  • A to G, chromosome 1 at 140,100,883 bp
  • A to G, chromosome 1 at 159,868,103 bp
  • A to G, chromosome 1 at 175,647,190 bp
  • A to G, chromosome 2 at 25,586,866 bp
  • T to A, chromosome 2 at 29,146,807 bp
  • C to A, chromosome 2 at 30,135,564 bp
  • A to C, chromosome 2 at 32,802,783 bp
  • T to C, chromosome 2 at 84,672,396 bp
  • A to G, chromosome 2 at 86,075,141 bp
  • A to G, chromosome 2 at 87,434,661 bp
  • A to G, chromosome 2 at 88,700,696 bp
  • T to A, chromosome 2 at 124,660,745 bp
  • T to A, chromosome 2 at 130,995,085 bp
  • T to A, chromosome 2 at 150,846,365 bp
  • A to T, chromosome 2 at 152,873,138 bp
  • A to G, chromosome 2 at 153,070,900 bp
  • A to G, chromosome 2 at 154,212,947 bp
  • C to T, chromosome 2 at 154,319,625 bp
  • T to C, chromosome 3 at 53,458,623 bp
  • A to G, chromosome 3 at 72,965,605 bp
  • T to C, chromosome 3 at 87,783,933 bp
  • T to C, chromosome 3 at 106,155,756 bp
  • C to T, chromosome 3 at 127,588,038 bp
  • T to C, chromosome 3 at 145,314,120 bp
  • T to C, chromosome 4 at 57,829,434 bp
  • T to A, chromosome 4 at 112,029,399 bp
  • T to C, chromosome 4 at 139,479,062 bp
  • A to G, chromosome 4 at 143,993,518 bp
  • A to T, chromosome 4 at 144,160,214 bp
  • T to C, chromosome 5 at 21,920,537 bp
  • T to C, chromosome 5 at 30,195,080 bp
  • T to C, chromosome 5 at 31,136,182 bp
  • T to C, chromosome 5 at 33,983,552 bp
  • AT to ATT, chromosome 5 at 62,649,907 bp
  • T to C, chromosome 5 at 87,929,871 bp
  • C to A, chromosome 5 at 114,261,068 bp
  • T to C, chromosome 5 at 121,343,232 bp
  • T to A, chromosome 5 at 142,776,739 bp
  • G to A, chromosome 6 at 38,747,485 bp
  • A to G, chromosome 6 at 42,642,511 bp
  • T to C, chromosome 6 at 90,689,970 bp
  • T to C, chromosome 6 at 118,602,213 bp
  • T to C, chromosome 6 at 132,626,737 bp
  • T to A, chromosome 6 at 135,017,122 bp
  • A to T, chromosome 6 at 149,033,262 bp
  • A to G, chromosome 7 at 10,100,469 bp
  • G to A, chromosome 7 at 25,714,420 bp
  • A to T, chromosome 7 at 42,819,978 bp
  • A to T, chromosome 7 at 84,995,276 bp
  • T to C, chromosome 7 at 99,594,677 bp
  • A to T, chromosome 7 at 104,021,989 bp
  • ACC to AC, chromosome 7 at 110,330,683 bp
  • G to A, chromosome 7 at 120,433,611 bp
  • T to G, chromosome 8 at 19,693,709 bp
  • A to C, chromosome 8 at 25,178,004 bp
  • A to T, chromosome 8 at 49,500,492 bp
  • A to G, chromosome 8 at 88,653,231 bp
  • T to A, chromosome 8 at 112,011,495 bp
  • A to G, chromosome 8 at 123,288,070 bp
  • T to A, chromosome 9 at 38,723,895 bp
  • A to T, chromosome 9 at 53,458,941 bp
  • T to C, chromosome 9 at 54,554,496 bp
  • A to G, chromosome 9 at 86,556,190 bp
  • T to C, chromosome 9 at 108,107,240 bp
  • A to T, chromosome 9 at 116,158,320 bp
  • G to A, chromosome 9 at 122,749,906 bp
  • A to T, chromosome 9 at 124,349,540 bp
  • C to T, chromosome 10 at 5,350,933 bp
  • ATAA to ATAATTAA, chromosome 10 at 14,760,719 bp
  • C to T, chromosome 10 at 41,481,315 bp
  • T to C, chromosome 10 at 70,536,352 bp
  • C to T, chromosome 10 at 76,208,683 bp
  • T to C, chromosome 10 at 92,829,650 bp
  • T to A, chromosome 10 at 94,799,368 bp
  • A to C, chromosome 10 at 115,239,299 bp
  • A to G, chromosome 11 at 55,311,843 bp
  • T to C, chromosome 11 at 58,817,149 bp
  • T to A, chromosome 11 at 66,926,172 bp
  • T to A, chromosome 11 at 70,510,669 bp
  • C to A, chromosome 11 at 75,162,931 bp
  • G to T, chromosome 11 at 99,986,495 bp
  • T to C, chromosome 11 at 100,102,275 bp
  • A to T, chromosome 11 at 110,279,689 bp
  • A to G, chromosome 11 at 119,242,804 bp
  • C to A, chromosome 12 at 4,937,401 bp
  • T to C, chromosome 12 at 56,534,855 bp
  • C to T, chromosome 12 at 65,097,317 bp
  • T to C, chromosome 12 at 72,483,014 bp
  • C to T, chromosome 13 at 12,221,432 bp
  • T to A, chromosome 13 at 14,280,442 bp
  • A to T, chromosome 13 at 49,264,697 bp
  • T to C, chromosome 13 at 49,654,445 bp
  • A to T, chromosome 13 at 59,702,259 bp
  • A to T, chromosome 13 at 59,816,855 bp
  • A to T, chromosome 13 at 65,152,878 bp
  • T to A, chromosome 13 at 68,678,606 bp
  • G to T, chromosome 13 at 97,970,355 bp
  • T to A, chromosome 15 at 9,592,758 bp
  • G to A, chromosome 15 at 25,738,005 bp
  • T to C, chromosome 15 at 81,998,198 bp
  • A to T, chromosome 15 at 91,752,278 bp
  • T to A, chromosome 15 at 99,082,660 bp
  • C to T, chromosome 15 at 103,356,315 bp
  • T to A, chromosome 16 at 23,155,410 bp
  • A to T, chromosome 16 at 32,752,107 bp
  • T to C, chromosome 16 at 91,501,682 bp
  • A to T, chromosome 17 at 21,819,704 bp
  • A to T, chromosome 17 at 26,216,617 bp
  • A to T, chromosome 17 at 31,193,912 bp
  • A to T, chromosome 17 at 33,305,463 bp
  • G to T, chromosome 17 at 35,153,560 bp
  • C to T, chromosome 17 at 35,961,187 bp
  • A to C, chromosome 17 at 63,384,992 bp
  • A to T, chromosome 17 at 71,700,509 bp
  • G to T, chromosome 17 at 72,603,583 bp
  • T to C, chromosome 18 at 5,117,002 bp
  • T to C, chromosome 18 at 12,419,258 bp
  • G to A, chromosome 18 at 25,112,679 bp
  • C to T, chromosome 18 at 37,357,047 bp
  • A to G, chromosome 18 at 69,946,552 bp
  • T to A, chromosome 19 at 6,928,160 bp
  • A to T, chromosome 19 at 8,896,019 bp
  • C to A, chromosome 19 at 11,112,400 bp
  • T to C, chromosome 19 at 13,146,363 bp
  • C to A, chromosome 19 at 13,502,536 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0617 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038806-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.