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Strain Name:
C57BL/6J-MtgxR0644Btlr/Mmmh
Stock Number:
038829-MU
Citation ID:
RRID:MMRRC_038829-MU
Other Names:
R0644 (G1), C57BL/6J-MtgxR0644Btlr
Major Collection:

Strain Information

Chmp2b
Name: charged multivesicular body protein 2B
Synonyms: 1190006E07Rik, chromatin modifying protein 2B
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68942
VEGA: 16
Homologene: 8534
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229096
Homologene: 34991
Atxn2
Name: ataxin 2
Synonyms: ATX2, 9630045M23Rik, Sca2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC155, RPC1, 9330175N20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Vps26c
Name: VPS26 endosomal protein sorting factor C
Synonyms: Dcra, Down syndrome critical region gene 3, Dscr3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13185
HGNC: HGNC:3044
Homologene: 4415
Rab27a
Name: RAB27A, member RAS oncogene family
Synonyms: 2410003M20Rik, 4933437C11Rik, 2210402C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11891
HGNC: HGNC:9766
Homologene: 3069
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74741
Homologene: 8873
Ass1
Name: argininosuccinate synthetase 1
Synonyms: ASS, Ass-1, fold
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Amtn
Name: amelotin
Synonyms: 5430427O21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71421
Homologene: 52640
Atp5po
Name: ATP synthase peripheral stalk subunit OSCP
Synonyms: D12Wsu28e, Atp5o
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Dera
Name: deoxyribose-phosphate aldolase
Synonyms: 2010002D22Rik, 2500002K03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232449
Homologene: 14562
Elf2
Name: E74-like factor 2
Synonyms: NERF-2, 2610036A20Rik, A230104O07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69257
HGNC: HGNC:3317
Homologene: 5006
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 8030475K17Rik, A330041G23Rik, 2610202E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Mboat4
Name: membrane bound O-acyltransferase domain containing 4
Synonyms: LOC234155, GOAT
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234155
Homologene: 19272
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Abcg4
Name: ATP binding cassette subfamily G member 4
Synonyms: 6430517O04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 192663
Homologene: 75179
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Entpd5
Name: ectonucleoside triphosphate diphosphohydrolase 5
Synonyms: mNTPase, NTPDase-5, ER-UDPase, NTPDase5, Cd39l4, Pcph
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12499
HGNC: HGNC:3367
Homologene: 37457
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329470
Homologene: 75335
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, MOR174-11, Olfr1164
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: 2200003A07Rik, Bklhd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Or5h26
Name: olfactory receptor family 5 subfamily H member 26
Synonyms: GA_x54KRFPKG5P-55389051-55388122, MOR183-1, Olfr196
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258775
Homologene: 74113
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: experimental autoimmune prostatitis antigen 1, Eapa1, 9530008N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192950
Homologene: 135717
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Acsbg1
Name: acyl-CoA synthetase bubblegum family member 1
Synonyms: E230019G03Rik, BG1, Lpd, Bgm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94180
Homologene: 9044
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Rps10-ps1
Name: ribosomal protein S10, pseudogene 1
Synonyms: Gm9180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 668457
Fndc3c1
Name: fibronectin type III domain containing 3C1
Synonyms: LOC333564
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 333564
Homologene: 46440
Tent5d
Name: terminal nucleotidyltransferase 5D
Synonyms: LOC213449, Fam46d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 213449
Homologene: 26572
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 31,514,819 bp
  • T to C, chromosome 2 at 32,297,521 bp
  • C to T, chromosome 2 at 66,533,061 bp
  • C to T, chromosome 2 at 76,594,840 bp
  • A to G, chromosome 2 at 82,976,897 bp
  • T to A, chromosome 2 at 88,093,289 bp
  • A to G, chromosome 2 at 93,839,229 bp
  • A to G, chromosome 2 at 132,842,594 bp
  • T to C, chromosome 2 at 174,645,863 bp
  • T to C, chromosome 3 at 16,204,892 bp
  • C to T, chromosome 3 at 51,308,131 bp
  • C to A, chromosome 3 at 95,622,548 bp
  • T to C, chromosome 3 at 97,210,497 bp
  • G to T, chromosome 5 at 88,378,124 bp
  • A to T, chromosome 5 at 106,898,256 bp
  • A to G, chromosome 5 at 121,811,005 bp
  • A to T, chromosome 6 at 137,783,048 bp
  • A to T, chromosome 6 at 143,013,224 bp
  • T to C, chromosome 7 at 144,411,849 bp
  • T to C, chromosome 8 at 34,115,219 bp
  • A to T, chromosome 9 at 4,329,868 bp
  • A to T, chromosome 9 at 44,274,699 bp
  • T to A, chromosome 9 at 54,609,826 bp
  • T to C, chromosome 9 at 66,955,890 bp
  • T to A, chromosome 9 at 73,095,423 bp
  • A to G, chromosome 9 at 105,948,324 bp
  • G to T, chromosome 9 at 108,563,637 bp
  • A to T, chromosome 9 at 123,051,458 bp
  • C to T, chromosome 11 at 6,599,486 bp
  • A to T, chromosome 12 at 84,386,141 bp
  • G to A, chromosome 14 at 24,484,164 bp
  • C to T, chromosome 14 at 103,602,150 bp
  • G to A, chromosome 16 at 59,167,616 bp
  • A to G, chromosome 16 at 65,540,532 bp
  • A to T, chromosome 16 at 91,926,484 bp
  • A to G, chromosome 16 at 94,502,195 bp
  • T to A, chromosome X at 106,434,962 bp
  • T to C, chromosome X at 107,870,645 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0644 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038829-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.