Strain Name:
C57BL/6J-MtgxR0681Btlr/Mmmh
Stock Number:
038866-MU
Citation ID:
RRID:MMRRC_038866-MU
Other Names:
R0681 (G1), C57BL/6J-MtgxR0681Btlr
Major Collection:

Gene Information

Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: Galnt9, GalNAc-T10, C330012K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171212
Homologene: 14924
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230793
Homologene: 17144
Plekha1
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: C920009D07Rik, TAPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101476
Homologene: 11001
Cdk13
Name: cyclin-dependent kinase 13
Synonyms: 2310015O17Rik, Cdc2l5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Slc39a3
Name: solute carrier family 39 (zinc transporter), member 3
Synonyms: zip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 106947
Homologene: 44230
Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53970
HGNC: HGNC:9986
Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13078
VEGA: 17
HGNC: HGNC:2597
Homologene: 68035
Palm
Name: paralemmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18483
VEGA: 10
HGNC: HGNC:8594
Homologene: 1937
Rrp1b
Name: ribosomal RNA processing 1 homolog B (S. cerevisiae)
Synonyms: 2600005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72462
Homologene: 57086
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: 2900070I05Rik, Lphn1, Lec2, lectomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Dock7
Name: dedicator of cytokinesis 7
Synonyms: LOC242555, 3110056M06Rik, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Grin2c
Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Synonyms: NR2C, GluRepsilon3, NMDAR2C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14813
HGNC: HGNC:4587
Homologene: 647
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Srsf15, Sfrs15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Cldn6
Name: claudin 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54419
HGNC: HGNC:2048
Homologene: 10300
Hsd17b11
Name: hydroxysteroid (17-beta) dehydrogenase 11
Synonyms: retSDR2, 17beta-HSD11, Pan1b, Dhrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 114664
Homologene: 69209
Per1
Name: period circadian clock 1
Synonyms: m-rigui, Hftm, mPer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Mapk9
Name: mitogen-activated protein kinase 9
Synonyms: Prkm9, JNK2, c-Jun N-terminal kinase, JNK/SAPK alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26420
HGNC: HGNC:6886
Homologene: 55685
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: MD44, MTSG1, B430305I03Rik, Atip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102103
Homologene: 100292
Sec22a
Name: SEC22 homolog A, vesicle trafficking protein
Synonyms: Sec22l2, 1810005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 317717
Homologene: 8246
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230119
Homologene: 8913
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Miox
Name: myo-inositol oxygenase
Synonyms: Aldrl6, 0610009I10Rik, C85427, RSOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56727
Homologene: 9732
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Gpr98, VLGR1, Mgr1, Mass1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 5730405M13Rik, 1300006G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66627
Homologene: 32588
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: mH1, Nav1.5c, SkM2, Nav1.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Htra1
Name: HtrA serine peptidase 1
Synonyms: insulin-like growth factor binding protein 5 protease, HtrA1, L56, RSPP11, Prss11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56213
HGNC: HGNC:9476
Homologene: 31114
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100121
Homologene: 8618
Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms: Slc25a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22227
Homologene: 22524
Grb14
Name: growth factor receptor bound protein 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50915
HGNC: HGNC:4565
Homologene: 3303
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: 1110001D15Rik, EG235580, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Vmn1r46
Name: vomeronasal 1 receptor 46
Synonyms: V1rb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113856
Homologene: 134021
Rab26
Name: RAB26, member RAS oncogene family
Synonyms: A830020M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328778
Homologene: 25655
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: SSB1, 4930422J18Rik, 1110014L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74646
Homologene: 11832
Pramel24
Name: PRAME like 24
Synonyms: Gm13078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277666
Homologene: 133722
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: 4931400F03Rik, eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Naprt
Name: nicotinate phosphoribosyltransferase
Synonyms: 9130210N20Rik, Naprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223646
VEGA: 15
Homologene: 82285
Hif1an
Name: hypoxia-inducible factor 1, alpha subunit inhibitor
Synonyms: FIH, 2310046M24Rik, A830014H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319594
Homologene: 9906
Olfr1445
Name: olfactory receptor 1445
Synonyms: MOR202-7, GA_x6K02T2RE5P-3213352-3214296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258694
Homologene: 133606
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50702
HGNC: HGNC:4888
Homologene: 55632
Med22
Name: mediator complex subunit 22
Synonyms: Surf-5, Surf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20933
Homologene: 4913
Cyb561d1
Name: cytochrome b-561 domain containing 1
Synonyms: 1600010M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72023
Homologene: 45651
Slc10a6
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 6
Synonyms: 8430417G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75750
Homologene: 12620
Olfr211
Name: olfactory receptor 211
Synonyms: GA_x54KRFPKN04-58127726-58128655, MOR253-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258914
Homologene: 17434
Trim8
Name: tripartite motif-containing 8
Synonyms: GERP, Rnf27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93679
VEGA: 19
Homologene: 12795
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 135,963,853 bp
  • A to T, chromosome 1 at 139,557,511 bp
  • T to C, chromosome 1 at 157,157,180 bp
  • T to C, chromosome 2 at 26,910,379 bp
  • G to T, chromosome 2 at 64,917,287 bp
  • C to T, chromosome 3 at 94,956,355 bp
  • A to G, chromosome 3 at 108,199,267 bp
  • T to C, chromosome 4 at 44,993,787 bp
  • T to A, chromosome 4 at 46,016,879 bp
  • G to A, chromosome 4 at 99,016,704 bp
  • T to C, chromosome 4 at 133,065,516 bp
  • A to T, chromosome 4 at 143,728,052 bp
  • C to T, chromosome 4 at 149,906,917 bp
  • A to G, chromosome 5 at 14,675,318 bp
  • C to A, chromosome 5 at 103,612,449 bp
  • T to A, chromosome 5 at 104,003,206 bp
  • A to G, chromosome 5 at 124,112,844 bp
  • A to T, chromosome 6 at 89,976,964 bp
  • A to T, chromosome 6 at 116,494,400 bp
  • T to C, chromosome 7 at 130,900,623 bp
  • A to T, chromosome 7 at 130,979,297 bp
  • A to T, chromosome 8 at 40,993,517 bp
  • C to T, chromosome 8 at 72,662,337 bp
  • T to A, chromosome 8 at 83,295,307 bp
  • G to T, chromosome 8 at 83,934,650 bp
  • T to A, chromosome 9 at 106,067,144 bp
  • A to T, chromosome 9 at 119,539,640 bp
  • A to C, chromosome 10 at 79,819,493 bp
  • C to G, chromosome 10 at 81,033,731 bp
  • C to T, chromosome 10 at 120,010,230 bp
  • T to A, chromosome 11 at 49,869,245 bp
  • T to A, chromosome 11 at 57,769,540 bp
  • A to G, chromosome 11 at 69,101,201 bp
  • A to G, chromosome 11 at 115,249,653 bp
  • A to G, chromosome 13 at 17,721,297 bp
  • C to T, chromosome 13 at 68,591,928 bp
  • C to A, chromosome 13 at 81,528,530 bp
  • T to C, chromosome 14 at 79,769,960 bp
  • G to A, chromosome 15 at 75,893,632 bp
  • C to T, chromosome 15 at 89,336,274 bp
  • C to T, chromosome 16 at 35,361,556 bp
  • G to A, chromosome 16 at 90,249,694 bp
  • C to A, chromosome 17 at 23,681,193 bp
  • A to G, chromosome 17 at 24,527,966 bp
  • T to C, chromosome 17 at 32,060,395 bp
  • T to C, chromosome 17 at 58,305,555 bp
  • T to G, chromosome 17 at 71,749,514 bp
  • A to G, chromosome 17 at 79,713,846 bp
  • T to C, chromosome 19 at 4,914,654 bp
  • T to C, chromosome 19 at 12,884,079 bp
  • A to G, chromosome 19 at 12,884,546 bp
  • T to C, chromosome 19 at 44,563,323 bp
  • C to A, chromosome 19 at 46,515,093 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0681 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038866-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.