Strain Name:
C57BL/6J-MtgxR0682Btlr/Mmmh
Stock Number:
038867-MU
Citation ID:
RRID:MMRRC_038867-MU
Other Names:
R0682 (G1), C57BL/6J-MtgxR0682Btlr
Major Collection:

Strain Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22427
Homologene: 6659
Mcoln3
Name: mucolipin 3
Synonyms: varitint-waddler, Va, 6720490O21Rik, TRPML3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 171166
Homologene: 10118
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Uck2
Name: uridine-cytidine kinase 2
Synonyms: TSA903, Umpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80914
Homologene: 40850
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216853
Homologene: 9995
Abcg1
Name: ATP binding cassette subfamily G member 1
Synonyms: White, Abc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11307
HGNC: HGNC:73
Homologene: 21022
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Abcd3
Name: ATP-binding cassette, sub-family D (ALD), member 3
Synonyms: PMP70, Pxmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19299
HGNC: HGNC:67
Homologene: 2140
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Atraid
Name: all-trans retinoic acid induced differentiation factor
Synonyms: HSPC013, p18, 0610007C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381629
Homologene: 15412
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: 2510038J07Rik, LD5-1, D430019P06Rik, Zfp192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 93681
Homologene: 21268
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69582
Homologene: 19575
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Galnt18
Name: polypeptide N-acetylgalactosaminyltransferase 18
Synonyms: 2900011G21Rik, Galntl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233733
Homologene: 18347
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Dph3b-ps
Name: diphthamide biosynthesis 3, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 620949
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56552
Homologene: 135915
Adamts9
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, Mhdaund4, Gsfund3, UND3, Mhdaund3, UND4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101401
Homologene: 18821
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20128
Homologene: 114426
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67016
Homologene: 56694
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545527
Homologene: 65043
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269109
Homologene: 41400
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Trim43c
Name: tripartite motif-containing 43C
Synonyms: Trim43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 666731
Homologene: 105432
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Whamm
Name: WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms: Whdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434204
Homologene: 45851
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: Cark, D830019J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435766
Homologene: 41084
Or9i14
Name: olfactory receptor family 9 subfamily I member 14
Synonyms: GA_x6K02T2RE5P-4147744-4146800, MOR211-2, Olfr1499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258792
Homologene: 17393
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: EG434264, Gm15438
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434264
Homologene: 37741
Pex26
Name: peroxisomal biogenesis factor 26
Synonyms: 4632428M11Rik, peroxisome biogenesis factor 26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74043
Homologene: 9922
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2, Olfr850
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258516
Homologene: 121552
Sdhd
Name: succinate dehydrogenase complex, subunit D, integral membrane protein
Synonyms: 3110001M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66925
VEGA: 9
Homologene: 37718
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
1700001J03Rik
Name: RIKEN cDNA 1700001J03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69282
Homologene: 86127
Rnf133
Name: ring finger protein 133
Synonyms: Greul2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 386611
Homologene: 44549
Rrp8
Name: ribosomal RNA processing 8
Synonyms: 2900001K19Rik, 1500003O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101867
Homologene: 5621
Asic2
Name: acid-sensing (proton-gated) ion channel 2
Synonyms: Mdeg, BNaC1a, BNC1, Accn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Vmn1r229
Name: vomeronasal 1 receptor 229
Synonyms: V1re1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171224
Homologene: 74319
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 59,558,234 bp
  • C to A, chromosome 1 at 123,905,125 bp
  • A to G, chromosome 1 at 157,179,209 bp
  • C to T, chromosome 1 at 159,852,307 bp
  • T to C, chromosome 1 at 167,236,690 bp
  • G to A, chromosome 1 at 172,284,597 bp
  • T to A, chromosome 2 at 41,295,641 bp
  • A to T, chromosome 3 at 58,636,811 bp
  • T to A, chromosome 3 at 89,231,132 bp
  • A to C, chromosome 3 at 121,769,567 bp
  • T to A, chromosome 3 at 146,128,090 bp
  • A to G, chromosome 3 at 154,940,028 bp
  • A to T, chromosome 4 at 41,428,620 bp
  • T to C, chromosome 4 at 141,628,125 bp
  • T to A, chromosome 5 at 31,052,268 bp
  • C to T, chromosome 5 at 113,960,657 bp
  • T to C, chromosome 5 at 146,184,840 bp
  • A to T, chromosome 6 at 23,649,570 bp
  • A to T, chromosome 6 at 92,903,802 bp
  • T to A, chromosome 6 at 121,184,404 bp
  • A to G, chromosome 6 at 124,061,170 bp
  • A to G, chromosome 7 at 12,810,284 bp
  • T to C, chromosome 7 at 13,625,223 bp
  • A to G, chromosome 7 at 80,514,579 bp
  • A to G, chromosome 7 at 81,586,138 bp
  • A to C, chromosome 7 at 104,429,182 bp
  • A to C, chromosome 7 at 105,734,011 bp
  • T to C, chromosome 7 at 111,520,015 bp
  • A to G, chromosome 7 at 141,805,669 bp
  • A to G, chromosome 8 at 33,267,820 bp
  • C to A, chromosome 9 at 19,477,349 bp
  • G to T, chromosome 9 at 50,600,605 bp
  • T to A, chromosome 9 at 66,481,981 bp
  • G to A, chromosome 9 at 88,582,146 bp
  • A to G, chromosome 9 at 90,249,862 bp
  • C to T, chromosome 9 at 95,484,443 bp
  • T to A, chromosome 10 at 58,463,804 bp
  • A to G, chromosome 10 at 127,083,482 bp
  • A to G, chromosome 11 at 60,725,147 bp
  • A to G, chromosome 11 at 69,562,446 bp
  • T to C, chromosome 11 at 80,886,680 bp
  • T to C, chromosome 13 at 21,526,760 bp
  • C to A, chromosome 13 at 106,546,816 bp
  • A to T, chromosome 17 at 20,814,688 bp
  • G to A, chromosome 17 at 31,111,251 bp
  • C to T, chromosome 19 at 13,815,137 bp
  • G to A, chromosome 19 at 34,573,612 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0682 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038867-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.