Strain Name:
C57BL/6J-MtgxR0689Btlr/Mmmh
Stock Number:
038874-MU
Citation ID:
RRID:MMRRC_038874-MU
Other Names:
R0689 (G1), C57BL/6J-MtgxR0689Btlr
Major Collection:

Gene Information

Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 8030492O04Rik, C230047C07Rik, 6720481N21Rik, AIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16396
Homologene: 88442
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78830
Homologene: 48235
Triobp
Name: TRIO and F-actin binding protein
Synonyms: EST478828, Tara, Mus EST 478828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110253
Homologene: 5104
Snx6
Name: sorting nexin 6
Synonyms: 2010006G21Rik, 2610032J07Rik, 2810425K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
G3bp1
Name: GTPase activating protein (SH3 domain) binding protein 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27041
Homologene: 38096
Skp1a
Name: S-phase kinase-associated protein 1A
Synonyms: 2610043E24Rik, 2610206H23Rik, p19Skp1, Tceb1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21402
Homologene: 38775
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22722
Homologene: 7604
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, 150kDa, 4732460C16Rik, CIF150, TAF2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: DNJ3, 1500017M13Rik, mDj3, HIRIP4, 2010206B19Rik, PRO3015
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56445
Homologene: 21193
Gas8
Name: growth arrest specific 8
Synonyms: Gas11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104346
HGNC: HGNC:4166
Homologene: 1135
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Nfyb
Name: nuclear transcription factor-Y beta
Synonyms: Cbf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18045
HGNC: HGNC:7805
Homologene: 38149
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Semaq, Sema6A-1, A730020P05Rik, VIa, sema
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Cadm3
Name: cell adhesion molecule 3
Synonyms: SynCAM3, Necl1, BIgR, Igsf4b, Tsll1, Necl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94332
Homologene: 10919
Olfm3
Name: olfactomedin 3
Synonyms: optimedin, B230206G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229759
Homologene: 17103
Zfp59
Name: zinc finger protein 59
Synonyms: Mfg-2, Mfg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22717
Homologene: 137243
Klf6
Name: Kruppel-like factor 6
Synonyms: Ierepo3, CPBP, Zf9, FM6, Copeb, FM2, Ierepo1, BCD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 23849
VEGA: 13
HGNC: HGNC:2235
Homologene: 996
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Trerf1
Name: transcriptional regulating factor 1
Synonyms: Trep-132, Trep132, 9430096I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224829
Homologene: 14129
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227449
Homologene: 9808
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320508
Homologene: 10854
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: 9630011N22Rik, Dpde3, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72054
HGNC: HGNC:2645
Homologene: 128623
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72685
Homologene: 8865
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20679
Homologene: 22631
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Liph
Name: lipase, member H
Synonyms: C130037N08Rik, D16Wsu119e, Lpdlr, PLA1B, mPA-PLA1, LPDLR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Cfap206
Name: cilia and flagella associated protein 206
Synonyms: 1700003M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69329
Homologene: 18713
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9430004C13Rik, 9630046L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Efcab7
Name: EF-hand calcium binding domain 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230500
Homologene: 19952
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, OTTMUSG00000020804, ENSMUSG00000044873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546983
Homologene: 115466
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81017
Homologene: 41799
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Dok4
Name: docking protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 114255
Homologene: 10009
Itgbl1
Name: integrin, beta-like 1
Synonyms: B930011D01Rik, with EGF-like repeat domains
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Aldh1a3
Name: aldehyde dehydrogenase family 1, subfamily A3
Synonyms: V1, retinaldehyde dehydrogenase 3, ALDH6, RALDH3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56847
HGNC: HGNC:409
Homologene: 68080
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73094
Homologene: 13001
Klk1b1
Name: kallikrein 1-related peptidase b1
Synonyms: mGK-1, Klk1, TK, mK1, tissue kallikrein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16623
HGNC: HGNC:6364
Homologene: 68141
Ces1g
Name: carboxylesterase 1G
Synonyms: Ces1, Ces-1, Ses-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Pgghg
Name: protein glucosylgalactosylhydroxylysine glucosidase
Synonyms: 5730511L01Rik, Athl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212974
Homologene: 16023
Pla2g12a
Name: phospholipase A2, group XIIA
Synonyms: Pla2g12, GXII, Rossy, 2310004B05Rik, mGXII-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66350
Homologene: 11328
Pcdhb21
Name: protocadherin beta 21
Synonyms: Pcdhb18, PcdhbU
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93892
HGNC: HGNC:8682
Homologene: 134302
Slc37a2
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms: Slc37a1, cI-2, G3PP, ci2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56857
Homologene: 41357
Olfr726
Name: olfactory receptor 726
Synonyms: MOR246-4, GA_x6K02T2PMLR-5775299-5774334
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258313
Homologene: 44957
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22033
Homologene: 27079
Ppp1r14d
Name: protein phosphatase 1, regulatory inhibitor subunit 14D
Synonyms: 2010107K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72112
Homologene: 9800
Hsd3b3
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
Synonyms: 9030618K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15494
Homologene: 133013
Tmem45b
Name: transmembrane protein 45b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235135
VEGA: 9
Homologene: 16349
Bpifc
Name: BPI fold containing family C
Synonyms: Bpil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270757
Homologene: 18383
Zfp2
Name: zinc finger protein 2
Synonyms: mkr-2, Fnp-2, Zfp-2, 9930007F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22678
Homologene: 121779
Tmem30c
Name: transmembrane protein 30C
Synonyms: 4933401B01Rik, 4933409A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71027
Homologene: 78138
Gykl1
Name: glycerol kinase-like 1
Synonyms: Gk-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14625
VEGA: 18
HGNC: HGNC:4289
Homologene: 21848
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 53,620,681 bp
  • C to T, chromosome 1 at 88,230,680 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • C to T, chromosome 1 at 106,030,504 bp
  • T to A, chromosome 1 at 173,344,452 bp
  • T to C, chromosome 1 at 191,997,876 bp
  • T to C, chromosome 2 at 71,311,493 bp
  • T to C, chromosome 2 at 119,229,612 bp
  • T to A, chromosome 2 at 152,983,127 bp
  • T to A, chromosome 2 at 155,182,178 bp
  • C to A, chromosome 2 at 168,935,201 bp
  • G to T, chromosome 3 at 98,741,979 bp
  • T to A, chromosome 3 at 115,122,545 bp
  • A to G, chromosome 3 at 116,793,628 bp
  • T to C, chromosome 3 at 129,881,298 bp
  • C to T, chromosome 4 at 34,722,668 bp
  • T to C, chromosome 4 at 99,904,784 bp
  • G to T, chromosome 4 at 100,974,876 bp
  • T to C, chromosome 4 at 101,611,253 bp
  • A to T, chromosome 4 at 102,966,252 bp
  • A to G, chromosome 5 at 14,714,019 bp
  • T to C, chromosome 7 at 5,803,610 bp
  • A to G, chromosome 7 at 27,853,717 bp
  • C to A, chromosome 7 at 28,897,049 bp
  • A to C, chromosome 7 at 43,970,719 bp
  • T to A, chromosome 7 at 66,402,005 bp
  • A to T, chromosome 7 at 84,593,184 bp
  • A to T, chromosome 7 at 86,811,664 bp
  • A to G, chromosome 7 at 115,486,551 bp
  • T to C, chromosome 7 at 140,943,278 bp
  • G to A, chromosome 8 at 71,330,756 bp
  • A to G, chromosome 8 at 71,995,968 bp
  • A to G, chromosome 8 at 85,546,718 bp
  • A to G, chromosome 8 at 93,328,407 bp
  • T to C, chromosome 8 at 94,870,919 bp
  • C to G, chromosome 8 at 109,623,649 bp
  • T to G, chromosome 8 at 123,524,106 bp
  • T to C, chromosome 9 at 31,428,583 bp
  • A to G, chromosome 9 at 37,235,550 bp
  • G to T, chromosome 10 at 53,348,847 bp
  • G to A, chromosome 10 at 82,755,002 bp
  • A to G, chromosome 10 at 85,960,547 bp
  • T to C, chromosome 11 at 50,900,907 bp
  • T to C, chromosome 11 at 52,243,765 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • A to T, chromosome 12 at 54,763,656 bp
  • T to A, chromosome 13 at 5,865,116 bp
  • T to C, chromosome 13 at 48,967,638 bp
  • C to T, chromosome 13 at 81,475,105 bp
  • T to C, chromosome 13 at 109,740,544 bp
  • A to T, chromosome 14 at 50,084,232 bp
  • A to T, chromosome 14 at 123,827,847 bp
  • A to G, chromosome 15 at 8,293,078 bp
  • A to T, chromosome 15 at 47,756,025 bp
  • A to T, chromosome 15 at 55,063,065 bp
  • A to T, chromosome 15 at 66,839,404 bp
  • A to T, chromosome 15 at 78,959,988 bp
  • A to G, chromosome 16 at 4,312,804 bp
  • T to C, chromosome 16 at 21,968,068 bp
  • A to G, chromosome 16 at 57,270,173 bp
  • T to C, chromosome 17 at 19,080,520 bp
  • C to T, chromosome 17 at 47,319,374 bp
  • A to G, chromosome 18 at 37,515,317 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • T to G, chromosome 18 at 52,694,051 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0689 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038874-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.