Strain Name:
C57BL/6J-MtgxR0697Btlr/Mmmh
Stock Number:
038881-MU
Citation ID:
RRID:MMRRC_038881-MU
Other Names:
R0697 (G1), C57BL/6J-MtgxR0697Btlr
Major Collection:

Gene Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22594
Homologene: 31368
Htr1b
Name: 5-hydroxytryptamine (serotonin) receptor 1B
Synonyms: 5-HT1B receptor, 5HT1B receptor, 5-HT1B receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15551
HGNC: HGNC:5287
Homologene: 669
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Crh
Name: corticotropin releasing hormone
Synonyms: CRF, corticotropin releasing factor, LOC383938, corticotropin-releasing factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12918
HGNC: HGNC:2355
Homologene: 599
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: Cpsf, 2610024B04Rik, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Kif13a
Name: kinesin family member 13A
Synonyms: N-3 kinesin, 4930505I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cyp2g1
Name: cytochrome P450, family 2, subfamily g, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13108
HGNC: HGNC:2633
Homologene: 75020
Ceacam15
Name: carcinoembryonic antigen-related cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101434
Homologene: 131210
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104015
Homologene: 48252
Gfra1
Name: glial cell line derived neurotrophic factor family receptor alpha 1
Synonyms: GDNFR-alpha, GFR alpha-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14585
HGNC: HGNC:4243
Homologene: 3855
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: B230114P05Rik, ADAMTSL6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207596
Homologene: 49796
A1cf
Name: APOBEC1 complementation factor
Synonyms: ACF, apobec-1 complementation factor, 1810073H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Frk
Name: fyn-related kinase
Synonyms: BSK/IYK, GTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Vmn1r84
Name: vomeronasal 1 receptor 84
Synonyms: V1rg11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171267
Homologene: 74328
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49F, Ly49f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16637
Homologene: 110821
RP23-208E23.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Sirt5
Name: sirtuin 5
Synonyms: 0610012J09Rik, 1500032M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68346
VEGA: 13
Homologene: 40825
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Aig1
Name: androgen-induced 1
Synonyms: CGI-103, 1500031O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66253
Homologene: 32297
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 2 at 20,743,861 bp
  • T to G, chromosome 2 at 112,358,494 bp
  • A to T, chromosome 2 at 150,472,909 bp
  • A to T, chromosome 3 at 5,401,733 bp
  • C to A, chromosome 3 at 19,694,077 bp
  • T to C, chromosome 3 at 103,060,300 bp
  • T to C, chromosome 6 at 15,411,233 bp
  • T to C, chromosome 6 at 130,016,724 bp
  • A to T, chromosome 7 at 12,362,763 bp
  • A to C, chromosome 7 at 16,673,520 bp
  • C to T, chromosome 7 at 24,570,319 bp
  • A to T, chromosome 7 at 26,814,727 bp
  • A to G, chromosome 9 at 59,989,102 bp
  • T to C, chromosome 9 at 81,631,463 bp
  • T to C, chromosome 10 at 13,829,325 bp
  • A to G, chromosome 10 at 34,607,837 bp
  • C to T, chromosome 10 at 39,088,752 bp
  • T to C, chromosome 10 at 62,949,341 bp
  • A to T, chromosome 12 at 74,976,531 bp
  • A to G, chromosome 12 at 101,983,184 bp
  • T to C, chromosome 13 at 43,385,576 bp
  • G to A, chromosome 13 at 46,848,337 bp
  • T to C, chromosome 15 at 58,105,543 bp
  • T to C, chromosome 16 at 90,960,615 bp
  • A to G, chromosome 18 at 20,041,452 bp
  • C to A, chromosome 19 at 31,911,167 bp
  • A to C, chromosome 19 at 58,270,123 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0697 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038881-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.