Strain Name:
C57BL/6J-MtgxR0701Btlr/Mmmh
Stock Number:
038884-MU
Citation ID:
RRID:MMRRC_038884-MU
Other Names:
R0701 (G1), C57BL/6J-MtgxR0701Btlr
Major Collection:

Gene Information

Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69188
Homologene: 18822
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234094
Homologene: 22827
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Csad
Name: cysteine sulfinic acid decarboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 246277
VEGA: 15
Homologene: 41086
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Cald1
Name: caldesmon 1
Synonyms: C920027I18Rik, 4833423D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 109624
HGNC: HGNC:1441
Homologene: 137254
Robo2
Name: roundabout guidance receptor 2
Synonyms: 2600013A04Rik, 9430089E08Rik, D230004I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268902
Homologene: 43188
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: Tmem24, 1300006O23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71764
VEGA: 9
Homologene: 8876
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 327987
Homologene: 21067
Ifnar2
Name: interferon (alpha and beta) receptor 2
Synonyms: Ifnar-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15976
HGNC: HGNC:5433
Homologene: 49242
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 21341
Homologene: 21163
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: ZAP-70, TZK, Srk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22637
Homologene: 839
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Ertd71e, D6Wsu16e, Copg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225348
VEGA: 18
Homologene: 6536
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 2700048G21Rik, CCCAP, 5730470G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76816
Homologene: 4839
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98910
Homologene: 6879
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237782
Homologene: 16989
Pdgfd
Name: platelet-derived growth factor, D polypeptide
Synonyms: 1110003I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71785
VEGA: 9
Homologene: 11875
Haus3
Name: HAUS augmin-like complex, subunit 3
Synonyms: D5H4S43, D4S43h, D5H4S43E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231123
Homologene: 75209
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: PGHS-2, cyclooxygenase-2, Pghs2, PHS-2, COX2, Tis10, prostaglandin G/H synthase, cyclooxygenase 2, Cox-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330470
Homologene: 86818
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103199
VEGA: 10
Homologene: 6713
Fmnl3
Name: formin-like 3
Synonyms: Wbp3, 2700073B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22379
Homologene: 69101
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69983
Homologene: 37424
Olfr395
Name: olfactory receptor 395
Synonyms: MOR135-10, GA_x6K02T2P1NL-4062605-4061667
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 259007
Nckap5
Name: NCK-associated protein 5
Synonyms: E030049G20Rik, D130011D22Rik, LOC380609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210356
Homologene: 35542
Arhgef11
Name: Rho guanine nucleotide exchange factor (GEF) 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213498
Homologene: 11409
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74978
Homologene: 46007
Ada
Name: adenosine deaminase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Sh2d4a
Name: SH2 domain containing 4A
Synonyms: 2210402M20Rik, SH2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72281
Homologene: 11117
Olfr1258
Name: olfactory receptor 1258
Synonyms: MOR232-3, GA_x6K02T2Q125-51361752-51362687
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258980
Homologene: 82299
Hoxb3
Name: homeobox B3
Synonyms: Hox-2.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15410
HGNC: HGNC:5114
Homologene: 1617
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106633
Homologene: 40979
Syt16
Name: synaptotagmin XVI
Synonyms: syt14r, Syt14l, Strep14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238266
VEGA: 12
Homologene: 12902
Gm13088
Name: predicted gene 13088
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 277668
Homologene: 129883
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: D230041A13Rik, Cmya4, UNC45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217012
Homologene: 14666
Gm10912
Name: predicted gene 10912
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Olfr1298
Name: olfactory receptor 1298
Synonyms: MOR248-6, GA_x6K02T2Q125-72697413-72696475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258888
Homologene: 121521
Mcur1
Name: mitochondrial calcium uniporter regulator 1
Synonyms: Ccdc90a, 6230416A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76137
VEGA: 13
Homologene: 134447
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22404
Homologene: 7997
Ddx31
Name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
Synonyms: 5830444G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227674
Homologene: 6389
C9
Name: complement component 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Lrrn4
Name: leucine rich repeat neuronal 4
Synonyms: B430119L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320974
Homologene: 17632
Stap1
Name: signal transducing adaptor family member 1
Synonyms: STAP-1, Brdg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56792
Homologene: 8103
Rab27b
Name: RAB27B, member RAS oncogene family
Synonyms: B130064M09Rik, 2310021G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 80718
HGNC: HGNC:9767
Homologene: 20879
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,781,177 bp
  • A to G, chromosome 1 at 126,025,357 bp
  • A to G, chromosome 1 at 128,181,739 bp
  • T to G, chromosome 1 at 150,101,198 bp
  • T to A, chromosome 1 at 176,824,918 bp
  • A to G, chromosome 2 at 6,415,018 bp
  • G to T, chromosome 2 at 28,858,777 bp
  • A to G, chromosome 2 at 76,898,068 bp
  • A to G, chromosome 2 at 89,930,201 bp
  • T to C, chromosome 2 at 104,066,530 bp
  • C to T, chromosome 2 at 111,645,791 bp
  • G to A, chromosome 2 at 132,870,160 bp
  • A to G, chromosome 2 at 163,730,075 bp
  • G to T, chromosome 3 at 72,941,045 bp
  • G to T, chromosome 3 at 87,733,459 bp
  • T to A, chromosome 4 at 32,699,263 bp
  • C to T, chromosome 4 at 143,656,440 bp
  • T to C, chromosome 5 at 23,473,583 bp
  • G to A, chromosome 5 at 34,166,015 bp
  • T to C, chromosome 5 at 86,094,808 bp
  • AAGAGAGAGAGAGAG to AAGAGAGAGAGAG, chromosome 6 at 34,746,173 bp
  • T to A, chromosome 6 at 87,894,107 bp
  • G to T, chromosome 7 at 13,472,256 bp
  • T to A, chromosome 8 at 14,962,636 bp
  • G to T, chromosome 8 at 45,026,553 bp
  • A to G, chromosome 8 at 68,331,095 bp
  • A to T, chromosome 8 at 119,599,983 bp
  • A to T, chromosome 9 at 6,359,706 bp
  • A to G, chromosome 9 at 44,316,202 bp
  • T to G, chromosome 9 at 66,487,950 bp
  • T to A, chromosome 10 at 41,240,512 bp
  • A to T, chromosome 10 at 103,234,044 bp
  • T to C, chromosome 11 at 60,778,115 bp
  • A to T, chromosome 11 at 73,906,829 bp
  • T to A, chromosome 11 at 82,940,205 bp
  • T to A, chromosome 11 at 86,307,038 bp
  • C to A, chromosome 11 at 96,346,248 bp
  • G to A, chromosome 12 at 74,235,112 bp
  • A to T, chromosome 12 at 85,267,903 bp
  • T to C, chromosome 13 at 43,545,740 bp
  • A to C, chromosome 15 at 6,467,421 bp
  • T to C, chromosome 15 at 99,321,307 bp
  • A to G, chromosome 15 at 102,179,136 bp
  • A to G, chromosome 16 at 74,046,874 bp
  • G to A, chromosome 16 at 87,719,989 bp
  • A to G, chromosome 16 at 91,404,229 bp
  • C to A, chromosome 17 at 15,725,431 bp
  • A to G, chromosome 17 at 25,090,933 bp
  • A to T, chromosome 17 at 32,356,441 bp
  • G to A, chromosome 18 at 32,839,466 bp
  • A to T, chromosome 18 at 69,985,199 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.