Strain Name:
C57BL/6J-MtgxR0702Btlr/Mmmh
Stock Number:
038885-MU
Citation ID:
RRID:MMRRC_038885-MU
Other Names:
R0702 (G1), C57BL/6J-MtgxR0702Btlr
Major Collection:

Gene Information

Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, DNA-PK, XRCC7, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Kpna4
Name: karyopherin (importin) alpha 4
Synonyms: IPOA3, 1110058D08Rik, importin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16649
HGNC: HGNC:6397
Homologene: 20521
Csnk1g1
Name: casein kinase 1, gamma 1
Synonyms: 9130020E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214897
HGNC: HGNC:2454
Homologene: 48692
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: SREBP-2, nuc, SREBP2, SREBP2gc, bHLHd2, lop13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20788
VEGA: 15
Homologene: 20966
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66515
Homologene: 56683
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Trpc5
Name: transient receptor potential cation channel, subfamily C, member 5
Synonyms: CCE2, TRP5, Trrp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22067
Homologene: 74915
Proser3
Name: proline and serine rich 3
Synonyms: BC053749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 333193
Homologene: 116064
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: Spi2-1, Spi2/eb.1, 2A2, alpha-1 antiproteinase,, alpha-1 antiproteinase, Spi2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Ano9
Name: anoctamin 9
Synonyms: 5430425C04Rik, Tp53i5, Trp53i5, Tmem16j
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71345
Homologene: 67083
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241770
Homologene: 18123
Notch4
Name: notch 4
Synonyms: Int-3, Int3, N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Herc6
Name: hect domain and RLD 6
Synonyms: 4930427L17Rik, 1700121D12Rik, CEB1, 2510038N07Rik, Herc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209966
Homologene: 11583
Slc2a13
Name: solute carrier family 2 (facilitated glucose transporter), member 13
Synonyms: A630029G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239606
Homologene: 43139
RP23-208E23.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Cd300ld
Name: CD300 molecule like family member d
Synonyms: Clm5, MAIR-IV, 4732429D16Rik, Cd300ld1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217305
Homologene: 129719
Olfr199
Name: olfactory receptor 199
Synonyms: GA_x54KRFPKG5P-55430495-55429569, MOR182-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 404310
Homologene: 37011
Dgat2l6
Name: diacylglycerol O-acyltransferase 2-like 6
Synonyms: 9930021F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 668257
Homologene: 79625
Ubqln2
Name: ubiquilin 2
Synonyms: HRIHFB2157, Dsk2, Chap1, Plic-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54609
Homologene: 81830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 45,380,131 bp
  • T to G, chromosome 2 at 112,358,494 bp
  • C to T, chromosome 2 at 163,863,929 bp
  • A to T, chromosome 3 at 69,084,105 bp
  • A to G, chromosome 3 at 89,230,220 bp
  • C to T, chromosome 3 at 97,566,794 bp
  • G to C, chromosome 3 at 109,872,254 bp
  • A to G, chromosome 5 at 5,644,465 bp
  • A to T, chromosome 5 at 90,474,707 bp
  • T to C, chromosome 6 at 57,581,107 bp
  • T to A, chromosome 6 at 67,466,285 bp
  • A to G, chromosome 6 at 103,706,622 bp
  • A to T, chromosome 7 at 30,539,530 bp
  • A to G, chromosome 7 at 141,107,282 bp
  • A to T, chromosome 8 at 122,889,766 bp
  • C to T, chromosome 8 at 124,374,255 bp
  • C to T, chromosome 9 at 66,010,493 bp
  • T to C, chromosome 11 at 114,986,091 bp
  • G to A, chromosome 12 at 64,472,001 bp
  • A to G, chromosome 12 at 104,241,253 bp
  • T to C, chromosome 15 at 82,177,409 bp
  • T to C, chromosome 15 at 91,321,667 bp
  • A to G, chromosome 16 at 15,785,971 bp
  • T to C, chromosome 16 at 59,215,699 bp
  • A to G, chromosome 17 at 34,575,203 bp
  • T to A, chromosome 17 at 46,663,190 bp
  • G to A, chromosome X at 100,542,681 bp
  • A to G, chromosome X at 144,411,739 bp
  • A to T, chromosome X at 153,499,669 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0702 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038885-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.