Strain Name:
C57BL/6J-MtgxR0712Btlr/Mmmh
Stock Number:
038895-MU
Citation ID:
RRID:MMRRC_038895-MU
Other Names:
R0712 (G1), C57BL/6J-MtgxR0712Btlr
Major Collection:

Gene Information

Penk
Name: preproenkephalin
Synonyms: ENK, Penk, PPA, Penk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Ubald2
Name: UBA-like domain containing 2
Synonyms: D030012E24Rik, 1110014K08Rik, Fam100b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319370
Homologene: 100077
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71728
Homologene: 12406
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, 2900037I21Rik, Scraps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Kpna6
Name: karyopherin (importin) alpha 6
Synonyms: IPOA7, NPI-2, importin alpha 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Tex264
Name: testis expressed gene 264
Synonyms: TEG-264
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21767
Homologene: 7975
Pcgf2
Name: polycomb group ring finger 2
Synonyms: Zfp144, mel-18, Rnf110, Mel18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22658
Homologene: 5174
Mastl
Name: microtubule associated serine/threonine kinase-like
Synonyms: THC2, 2700091H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67121
Homologene: 12086
Dnaaf4
Name: dynein axonemal assembly factor 4
Synonyms: EKN1, 1700010I24Rik, b2b811Clo, Dyx1c1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67685
Homologene: 12173
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Synpo2l
Name: synaptopodin 2-like
Synonyms: 1110054M18Rik, Chap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68760
Homologene: 23499
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Cap2
Name: CAP, adenylate cyclase-associated protein, 2 (yeast)
Synonyms: 2810452G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67252
Homologene: 101397
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67155
Homologene: 2308
Dpm1
Name: dolichol-phosphate (beta-D) mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13480
HGNC: HGNC:3005
Homologene: 2865
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103836
Homologene: 9889
Olfr984
Name: olfactory receptor 984
Synonyms: GA_x6K02T2PVTD-33799484-33798540, MOR239-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104010
Homologene: 23148
Olfr102
Name: olfactory receptor 102
Synonyms: MOR250-4, GA_x6K02T2PSCP-1775063-1774137
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258218
HGNC: HGNC:8178
Homologene: 133728
Abcd1
Name: ATP-binding cassette, sub-family D (ALD), member 1
Synonyms: ALDP, Ald, Aldgh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 11666
HGNC: HGNC:61
Homologene: 55426
Hdac8
Name: histone deacetylase 8
Synonyms: 2610007D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 70315
Homologene: 41274
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 75,527,447 bp
  • T to C, chromosome 1 at 133,730,478 bp
  • A to G, chromosome 2 at 23,150,993 bp
  • A to G, chromosome 2 at 165,170,656 bp
  • T to C, chromosome 2 at 168,219,213 bp
  • T to A, chromosome 3 at 86,297,990 bp
  • T to C, chromosome 4 at 4,134,257 bp
  • A to G, chromosome 4 at 129,656,407 bp
  • A to T, chromosome 9 at 22,380,298 bp
  • A to G, chromosome 9 at 40,101,430 bp
  • A to T, chromosome 9 at 55,004,363 bp
  • G to T, chromosome 9 at 72,960,657 bp
  • A to C, chromosome 9 at 106,659,232 bp
  • G to A, chromosome 10 at 52,144,882 bp
  • T to C, chromosome 11 at 30,791,247 bp
  • T to C, chromosome 11 at 58,314,314 bp
  • T to C, chromosome 11 at 59,049,445 bp
  • T to C, chromosome 11 at 97,691,004 bp
  • T to C, chromosome 11 at 116,434,575 bp
  • A to G, chromosome 12 at 54,922,621 bp
  • T to C, chromosome 13 at 46,615,361 bp
  • A to G, chromosome 14 at 20,661,839 bp
  • T to A, chromosome 17 at 37,314,084 bp
  • A to G, chromosome 17 at 67,779,042 bp
  • G to A, chromosome 18 at 68,307,788 bp
  • A to G, chromosome 19 at 26,681,951 bp
  • G to A, chromosome X at 73,730,865 bp
  • T to A, chromosome X at 102,499,918 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0712 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038895-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.