Strain Name:
C57BL/6J-MtgxR0724Btlr/Mmmh
Stock Number:
038906-MU
Citation ID:
RRID:MMRRC_038906-MU
Other Names:
R0724 (G1), C57BL/6J-MtgxR0724Btlr
Major Collection:

Gene Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-B, ankyrin B, Ankyrin-2, Ank-2, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: OTTMUSG00000022087, C130080N23Rik, PTP36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Dst
Name: dystonin
Synonyms: ah, athetoid, A830042E19Rik, nmf203, Macf2, BPAG1, 2310001O04Rik, BPAG1-n, bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, Bpag, Bpag1, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: Dopey2, 2610510B01Rik, 0610038M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: PDI, Grp58, PDI-Q2, ERp61, Plca, ERp57, ERp60, Erp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244672
Homologene: 12366
Dyrk3
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Sirt1
Name: sirtuin 1
Synonyms: Sir2, Sir2alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 93759
Homologene: 56556
Kpnb1
Name: karyopherin (importin) beta 1
Synonyms: Impnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: LRN, 2810008P14Rik, SAP25, LRRN4, 2900069C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Thoc1
Name: THO complex 1
Synonyms: NMP-84, 3110002N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22388
Homologene: 6628
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, hypothroid, pet
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22095
Homologene: 315
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: DR6, TR7, Death receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100072
Homologene: 18942
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59035
Homologene: 10990
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: 1810007M14Rik, Pax3/7bp, Gcfc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67367
Homologene: 9604
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, Cst-1, calsyntenin-1, 1810034E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65945
Homologene: 8814
Sost
Name: sclerostin
Synonyms: 5430411E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74499
Homologene: 11542
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Emp2
Name: epithelial membrane protein 2
Synonyms: Xmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13731
HGNC: HGNC:3334
Homologene: 1089
Casp1
Name: caspase 1
Synonyms: Caspase-1, Il1bc, ICE, interleukin 1 beta-converting enzyme
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12362
VEGA: 9
HGNC: HGNC:1499
Homologene: 133272
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, Nalp2, Nbs1, Pan1, E330007A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: mixed lineage kinase 2, MKN28 kinase, Mlk2, serine/threonine kinase, MKN28 derived nonreceptor_type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Gata3
Name: GATA binding protein 3
Synonyms: jal, Gata-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 213550
Homologene: 15797
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: FIRE, Gpr127, D17Ertd479e, EGF-TM7, Emr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53419
Homologene: 4804
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: A230020K05Rik, Fam115a, 3321401G04Rik, 2810407D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77574
Homologene: 8815
Gm1043
Name: predicted gene 1043
Synonyms: LOC381634
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381634
Homologene: 52625
Cryba1
Name: crystallin, beta A1
Synonyms: Cryb, BA3/A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12957
HGNC: HGNC:2394
Homologene: 3815
Gm15448
Name: predicted gene 15448
Synonyms: ENSMUSG00000074419
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100041146
HGNC: HGNC:6607
Homologene: 134028
1700018F24Rik
Name: RIKEN cDNA 1700018F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69396
Homologene: 86127
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208151
Homologene: 28135
Oacyl
Name: O-acyltransferase like
Synonyms: 5330437I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319888
Homologene: 129774
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239318
Homologene: 45574
Olfr735
Name: olfactory receptor 735
Synonyms: GA_x6K02T2PMLR-6042130-6041183, MOR243-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 257909
Homologene: 71977
Klhdc2
Name: kelch domain containing 2
Synonyms: D12Ertd522e, 2310022K15Rik, HCLP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69554
Homologene: 8631
Zfp697
Name: zinc finger protein 697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242109
Homologene: 18241
Smim14
Name: small integral membrane protein 14
Synonyms: 5430439C17Rik, 1700127H04Rik, MAd4, 1110003E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68552
Homologene: 64466
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Hand1
Name: heart and neural crest derivatives expressed 1
Synonyms: Thing1, Th1, bHLHa27, Ehand1, Hxt, eHAND
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15110
HGNC: HGNC:4807
Homologene: 3545
Ccdc122
Name: coiled-coil domain containing 122
Synonyms: 4933415L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108811
Homologene: 51651
Hoxc12
Name: homeobox C12
Synonyms: Hox-3.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15421
HGNC: HGNC:5124
Homologene: 7769
H2-Eb1
Name: histocompatibility 2, class II antigen E beta
Synonyms: Ia4, H-2Eb, Ia-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14969
HGNC: HGNC:4953
Homologene: 101524
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,188,677 bp
  • T to C, chromosome 1 at 131,130,140 bp
  • T to C, chromosome 1 at 189,850,947 bp
  • T to C, chromosome 2 at 9,874,575 bp
  • G to A, chromosome 2 at 121,432,377 bp
  • A to T, chromosome 2 at 125,352,064 bp
  • C to A, chromosome 3 at 98,297,001 bp
  • T to C, chromosome 3 at 98,428,166 bp
  • A to T, chromosome 3 at 101,592,439 bp
  • C to T, chromosome 3 at 126,962,337 bp
  • A to C, chromosome 4 at 149,643,624 bp
  • A to G, chromosome 4 at 151,077,892 bp
  • A to G, chromosome 5 at 37,187,229 bp
  • A to G, chromosome 5 at 38,540,862 bp
  • A to G, chromosome 5 at 65,453,339 bp
  • A to G, chromosome 5 at 72,332,795 bp
  • A to G, chromosome 5 at 88,501,994 bp
  • A to G, chromosome 5 at 96,828,748 bp
  • A to T, chromosome 5 at 125,783,421 bp
  • A to T, chromosome 5 at 137,637,308 bp
  • A to G, chromosome 5 at 145,044,763 bp
  • G to T, chromosome 6 at 42,675,367 bp
  • T to C, chromosome 7 at 3,816,872 bp
  • G to T, chromosome 7 at 5,319,222 bp
  • A to C, chromosome 7 at 27,668,355 bp
  • A to G, chromosome 7 at 139,516,663 bp
  • A to G, chromosome 8 at 93,039,513 bp
  • T to A, chromosome 8 at 105,050,195 bp
  • G to T, chromosome 9 at 3,421,377 bp
  • C to T, chromosome 9 at 5,303,077 bp
  • A to G, chromosome 9 at 21,587,374 bp
  • T to C, chromosome 9 at 64,307,126 bp
  • T to C, chromosome 10 at 63,323,973 bp
  • T to C, chromosome 11 at 57,831,680 bp
  • T to C, chromosome 11 at 77,719,457 bp
  • T to C, chromosome 11 at 97,178,304 bp
  • C to T, chromosome 11 at 101,966,918 bp
  • C to A, chromosome 12 at 69,297,048 bp
  • T to C, chromosome 12 at 91,538,286 bp
  • T to A, chromosome 12 at 105,710,254 bp
  • A to G, chromosome 14 at 50,345,917 bp
  • G to A, chromosome 14 at 54,735,186 bp
  • C to A, chromosome 14 at 77,092,077 bp
  • G to A, chromosome 15 at 4,516,868 bp
  • A to G, chromosome 15 at 102,937,055 bp
  • C to T, chromosome 16 at 10,284,615 bp
  • T to A, chromosome 16 at 91,036,536 bp
  • A to G, chromosome 16 at 93,762,325 bp
  • T to C, chromosome 17 at 34,315,032 bp
  • C to T, chromosome 17 at 43,038,213 bp
  • T to A, chromosome 17 at 55,852,281 bp
  • T to C, chromosome 18 at 9,963,829 bp
  • G to A, chromosome 18 at 32,005,549 bp
  • T to C, chromosome 18 at 65,737,825 bp
  • G to A, chromosome 19 at 6,963,392 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0724 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038906-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.