Strain Name:
C57BL/6J-MtgxR0736Btlr/Mmmh
Stock Number:
038917-MU
Citation ID:
RRID:MMRRC_038917-MU
Other Names:
R0736 (G1), C57BL/6J-MtgxR0736Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231051
Homologene: 46480
Calb1
Name: calbindin 1
Synonyms: CB, CalbindinD28K, Calb-1, Calb, calbindin, calbindin-D (28k), Brain-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12307
HGNC: HGNC:1434
Homologene: 21026
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Cep55
Name: centrosomal protein 55
Synonyms: 1200008O12Rik, 2700032M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 74107
VEGA: 19
HGNC: HGNC:1161
Homologene: 10019
Tns3
Name: tensin 3
Synonyms: TEM6, Tens1, F830010I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319939
Homologene: 49713
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320487
VEGA: 12
Homologene: 19635
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Zfp100, mZ13, Miz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22642
Homologene: 2575
Tspan5
Name: tetraspanin 5
Synonyms: 2810455A09Rik, Tm4sf9, 4930505M03Rik, NET-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56224
Homologene: 4182
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Neo1
Name: neogenin
Synonyms: Igdcc2, 2610028H22Rik, D930014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: Tmem24, 1300006O23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71764
VEGA: 9
Homologene: 8876
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: b2b1982Clo, Zfp161, ZF5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22666
Homologene: 2560
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12294
Homologene: 74929
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Mapk9
Name: mitogen-activated protein kinase 9
Synonyms: c-Jun N-terminal kinase, Prkm9, JNK2, JNK/SAPK alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 26420
HGNC: HGNC:6886
Homologene: 55685
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 83490
VEGA: 19
Homologene: 12848
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76131
Homologene: 9834
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107368
VEGA: 19
Homologene: 14879
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243874
Homologene: 18530
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900093J19Rik, Pmng1, Nztf1, Png-1, 2900046C06Rik, C630034G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
9330182L06Rik
Name: RIKEN cDNA 9330182L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231014
Homologene: 27396
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381852
Homologene: 115938
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18115
HGNC: HGNC:7863
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2-c, Slp2, Slp2-d, Slp2-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 83671
Homologene: 131343
Aox4
Name: aldehyde oxidase 4
Synonyms: 2310003G12Rik, AOH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71872
Homologene: 70273
Amn1
Name: antagonist of mitotic exit network 1
Synonyms: C730024G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232566
Homologene: 45811
Slfn1
Name: schlafen 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20555
Homologene: 86967
Cdk15
Name: cyclin-dependent kinase 15
Synonyms: Als2cr7, Pftk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 271697
Homologene: 64641
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225004
VEGA: 17
Homologene: 19792
St8sia6
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Synonyms: 1700007J08Rik, ST8Sia VI, Siat8f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241230
Homologene: 17112
Zw10
Name: zw10 kinetochore protein
Synonyms: 6330566F14Rik, MmZw10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26951
VEGA: 9
Homologene: 37959
Polm
Name: polymerase (DNA directed), mu
Synonyms: Tdt-N, B230309I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 195434
Homologene: 78703
Pgc
Name: progastricsin (pepsinogen C)
Synonyms: Upg-1, 2210410L06Rik, Upg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 109820
HGNC: HGNC:8890
Homologene: 55669
Cybb
Name: cytochrome b-245, beta polypeptide
Synonyms: Nox2, gp91phox, gp91phox, Cgd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 13058
HGNC: HGNC:2578
Homologene: 68054
Morc4
Name: microrchidia 4
Synonyms: 1600017G11Rik, 5630401M14Rik, Zcwcc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 75746
Homologene: 11644
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,228,060 bp
  • A to T, chromosome 1 at 59,258,809 bp
  • A to G, chromosome 1 at 78,665,272 bp
  • C to T, chromosome 1 at 90,804,089 bp
  • C to T, chromosome 2 at 13,668,885 bp
  • A to T, chromosome 2 at 52,192,012 bp
  • T to C, chromosome 3 at 19,231,043 bp
  • T to C, chromosome 3 at 138,868,398 bp
  • C to T, chromosome 3 at 159,527,935 bp
  • G to A, chromosome 4 at 15,898,917 bp
  • C to A, chromosome 4 at 141,461,786 bp
  • A to T, chromosome 5 at 9,441,745 bp
  • C to T, chromosome 5 at 25,295,434 bp
  • G to A, chromosome 6 at 149,183,472 bp
  • A to T, chromosome 7 at 17,873,426 bp
  • A to T, chromosome 7 at 20,049,450 bp
  • A to T, chromosome 7 at 24,989,970 bp
  • T to C, chromosome 7 at 90,403,020 bp
  • G to A, chromosome 8 at 27,385,050 bp
  • C to T, chromosome 9 at 44,315,282 bp
  • C to T, chromosome 9 at 49,064,132 bp
  • C to T, chromosome 9 at 54,378,817 bp
  • G to A, chromosome 9 at 58,917,081 bp
  • G to C, chromosome 11 at 5,835,495 bp
  • A to T, chromosome 11 at 8,519,474 bp
  • G to A, chromosome 11 at 49,883,254 bp
  • A to T, chromosome 11 at 83,121,081 bp
  • T to A, chromosome 12 at 29,827,814 bp
  • A to C, chromosome 12 at 51,896,561 bp
  • A to G, chromosome 13 at 119,354,751 bp
  • A to T, chromosome 14 at 29,058,628 bp
  • A to G, chromosome 15 at 16,830,878 bp
  • T to A, chromosome 17 at 47,728,780 bp
  • A to G, chromosome 17 at 69,387,802 bp
  • A to G, chromosome 17 at 71,744,664 bp
  • C to A, chromosome 19 at 38,073,317 bp
  • T to A, chromosome 19 at 41,332,319 bp
  • C to A, chromosome 19 at 59,344,933 bp
  • G to A, chromosome X at 9,469,196 bp
  • G to T, chromosome X at 139,854,951 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0736 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038917-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.