Strain Name:
C57BL/6J-MtgxR0741Btlr/Mmmh
Stock Number:
038922-MU
Citation ID:
RRID:MMRRC_038922-MU
Other Names:
R0741 (G1), C57BL/6J-MtgxR0741Btlr
Major Collection:

Gene Information

Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Nr2f2
Name: nuclear receptor subfamily 2, group F, member 2
Synonyms: ARP-1, 9430015G03Rik, EAR3, Aporp1, Tcfcoup2, COUP-TF2, COUP-TFII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11819
HGNC: HGNC:7976
Homologene: 7628
Nes
Name: nestin
Synonyms: RC2, Ifaprc2, ESTM46, Marc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67604
Homologene: 41080
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 30940
VEGA: 16
Homologene: 8374
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208718
Homologene: 62417
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, rede, Aip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22388
Homologene: 6628
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, Gtl6, 1110036I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14897
Homologene: 44226
Ago2
Name: argonaute RISC catalytic subunit 2
Synonyms: 2310051F07Rik, Eif2c2, 1110029L17Rik, argonaute 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239528
HGNC: HGNC:3263
Homologene: 81825
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Garnl1, Tulip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56784
VEGA: 12
Homologene: 84805
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218236
VEGA: 13
Homologene: 8752
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Txndc5
Name: thioredoxin domain containing 5
Synonyms: PC-TRP, ERp46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105245
Homologene: 11125
Pnkd
Name: paroxysmal nonkinesiogenic dyskinesia
Synonyms: 2810403H05Rik, Brp17, 2210013N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56695
HGNC: HGNC:9153
Homologene: 75045
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11982
Homologene: 56461
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 15257
Homologene: 56483
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Ptprh
Name: protein tyrosine phosphatase, receptor type, H
Synonyms: SAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 104002
Homologene: 122226
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Eps8l3
Name: EPS8-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99662
Homologene: 15878
Olfr512
Name: olfactory receptor 512
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258719
Homologene: 138316
Caskin2
Name: CASK-interacting protein 2
Synonyms: 1600028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 140721
Homologene: 32485
Kif21b
Name: kinesin family member 21B
Synonyms: 2610511N21Rik, N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16565
Homologene: 56868
Hdac10
Name: histone deacetylase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 170787
Homologene: 23749
Mvb12a
Name: multivesicular body subunit 12A
Synonyms: 1110012M11Rik, Fam125a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 73711
Homologene: 12509
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: LOC218476, Gm73, C2GNT3, LOC238786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218476
VEGA: 13
Homologene: 41144
Ano7
Name: anoctamin 7
Synonyms: NGEP, Tmem16g, Pcanap5, NGEP-L, IPCA-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 404545
Homologene: 45787
Nol3
Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
Synonyms: Nop30, B430311C09Rik, ARC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78688
HGNC: HGNC:7869
Homologene: 31208
Fbxw22
Name: F-box and WD-40 domain protein 22
Synonyms: Gm5164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382156
Homologene: 110776
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: D030055C23Rik, Asb-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 117589
Homologene: 34130
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, 6530401N04Rik, B830049N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 328092
Homologene: 12634
Mrps9
Name: mitochondrial ribosomal protein S9
Synonyms: 2310002A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 69527
Homologene: 32565
Cryba4
Name: crystallin, beta A4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12959
HGNC: HGNC:2396
Homologene: 1422
Klk1b22
Name: kallikrein 1-related peptidase b22
Synonyms: Egfbp-1, Egfbp1, Klk22, mGk-22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13646
HGNC: HGNC:6364
Homologene: 68141
Vgll1
Name: vestigial like family member 1
Synonyms: Tondu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 170828
Homologene: 9445
Magee2
Name: melanoma antigen, family E, 2
Synonyms: 9630059J11Rik, Mage-e2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 272790
Homologene: 16338
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,383,375 bp
  • A to G, chromosome 1 at 42,851,440 bp
  • T to A, chromosome 1 at 74,351,859 bp
  • A to G, chromosome 1 at 84,745,181 bp
  • T to C, chromosome 1 at 87,047,586 bp
  • T to A, chromosome 1 at 93,401,587 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • A to G, chromosome 1 at 136,159,744 bp
  • A to G, chromosome 3 at 87,978,967 bp
  • A to G, chromosome 3 at 103,746,812 bp
  • A to G, chromosome 3 at 107,882,825 bp
  • A to G, chromosome 3 at 118,674,505 bp
  • A to T, chromosome 5 at 37,326,395 bp
  • A to T, chromosome 5 at 38,527,921 bp
  • G to A, chromosome 5 at 112,246,688 bp
  • G to A, chromosome 5 at 139,263,629 bp
  • A to G, chromosome 7 at 4,554,173 bp
  • T to C, chromosome 7 at 44,116,709 bp
  • T to A, chromosome 7 at 58,828,589 bp
  • A to T, chromosome 7 at 66,660,134 bp
  • G to A, chromosome 7 at 70,357,997 bp
  • A to G, chromosome 7 at 80,720,987 bp
  • T to A, chromosome 7 at 108,713,604 bp
  • A to T, chromosome 8 at 45,027,474 bp
  • C to T, chromosome 8 at 71,543,069 bp
  • C to G, chromosome 8 at 105,279,124 bp
  • G to A, chromosome 9 at 109,382,219 bp
  • CCACACACACACAC to CCACACACACAC, chromosome 11 at 59,063,453 bp
  • A to G, chromosome 11 at 115,804,800 bp
  • T to C, chromosome 12 at 51,999,672 bp
  • A to C, chromosome 12 at 55,676,581 bp
  • T to C, chromosome 13 at 38,528,260 bp
  • A to G, chromosome 13 at 48,891,940 bp
  • T to C, chromosome 13 at 52,929,602 bp
  • T to A, chromosome 13 at 61,036,205 bp
  • T to C, chromosome 13 at 68,579,539 bp
  • G to T, chromosome 13 at 96,946,432 bp
  • A to C, chromosome 15 at 73,116,295 bp
  • A to T, chromosome 15 at 89,124,816 bp
  • C to A, chromosome 16 at 77,071,708 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • A to T, chromosome X at 57,096,284 bp
  • A to G, chromosome X at 104,855,866 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0741 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038922-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.