Strain Name:
C57BL/6J-MtgxR0749Btlr/Mmmh
Stock Number:
038929-MU
Citation ID:
RRID:MMRRC_038929-MU
Other Names:
R0749 (G1), C57BL/6J-MtgxR0749Btlr
Major Collection:

Gene Information

Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224807
Homologene: 101682
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20981
Homologene: 9617
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m239Asp, m275Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Cpt1c
Name: carnitine palmitoyltransferase 1c
Synonyms: CPT I-C, 9630004I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78070
Homologene: 17561
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: GPP34R, 2010204I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229593
Homologene: 23082
Atxn2l
Name: ataxin 2-like
Synonyms: A2RP, A2LG, A2D, A2lp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233871
Homologene: 16513
Hmgxb4
Name: HMG box domain containing 4
Synonyms: 4733401K04Rik, Hmgb2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70823
HGNC: HGNC:5003
Homologene: 4007
Sars
Name: seryl-aminoacyl-tRNA synthetase
Synonyms: Strs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20226
Homologene: 4751
Aprt
Name: adenine phosphoribosyl transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11821
HGNC: HGNC:626
Homologene: 413
Bbs9
Name: Bardet-Biedl syndrome 9 (human)
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319845
Homologene: 44480
Oma1
Name: OMA1 zinc metallopeptidase
Synonyms: 2010001O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67013
Homologene: 12070
Metap2
Name: methionine aminopeptidase 2
Synonyms: p67, eIF-2-associated p67, A930035J23Rik, 4930584B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56307
Homologene: 4981
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240667
Homologene: 56708
Nuak1
Name: NUAK family, SNF1-like kinase, 1
Synonyms: B230104P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77976
Homologene: 8896
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Dpy19l1
Name: dpy-19-like 1 (C. elegans)
Synonyms: 1100001I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244745
Homologene: 14762
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238555
HGNC: HGNC:1137
Homologene: 56012
Lipn
Name: lipase, family member N
Synonyms: 2210418G03Rik, Lipl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70166
Homologene: 66969
Zmynd10
Name: zinc finger, MYND domain containing 10
Synonyms: Blu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114602
Homologene: 9293
Krt2
Name: keratin 2
Synonyms: Krt2-2, Krt2e, Krt2-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PtdSer Synthase-1, PSS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Cyp3a16
Name: cytochrome P450, family 3, subfamily a, polypeptide 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13114
HGNC: HGNC:2638
Homologene: 133568
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Gm10258
Name: predicted gene 10258
Synonyms: EG545510
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545510
Gm12814
Name: predicted gene 12814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 630887
Gm8688
Name: predicted gene 8688
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Bmp4
Name: bone morphogenetic protein 4
Synonyms: Bmp2b1, Bmp2b, Bmp2b-1, Bmp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12159
HGNC: HGNC:1071
Homologene: 7247
Mcpt2
Name: mast cell protease 2
Synonyms: MMCP-2, Mcp-2, MMCP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17225
VEGA: 14
Gm6994
Name: predicted gene 6994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 629678
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 3 at 30,268,512 bp
  • G to A, chromosome 3 at 95,607,949 bp
  • A to C, chromosome 3 at 108,428,266 bp
  • C to T, chromosome 4 at 103,325,299 bp
  • T to C, chromosome 4 at 112,592,933 bp
  • T to A, chromosome 5 at 145,456,177 bp
  • A to G, chromosome 7 at 44,399,147 bp
  • A to G, chromosome 7 at 44,962,826 bp
  • A to T, chromosome 7 at 126,500,837 bp
  • A to G, chromosome 8 at 75,000,937 bp
  • T to G, chromosome 8 at 99,664,520 bp
  • A to T, chromosome 8 at 122,575,410 bp
  • T to C, chromosome 9 at 22,575,201 bp
  • T to A, chromosome 9 at 24,462,584 bp
  • T to C, chromosome 9 at 107,548,683 bp
  • T to C, chromosome 10 at 76,381,364 bp
  • T to C, chromosome 10 at 84,374,784 bp
  • T to C, chromosome 10 at 93,879,567 bp
  • A to G, chromosome 11 at 115,276,845 bp
  • A to G, chromosome 12 at 64,982,698 bp
  • T to C, chromosome 13 at 23,478,398 bp
  • T to A, chromosome 13 at 66,987,850 bp
  • T to C, chromosome 14 at 46,384,613 bp
  • A to G, chromosome 14 at 56,043,679 bp
  • G to A, chromosome 14 at 77,480,114 bp
  • G to T, chromosome 15 at 85,818,074 bp
  • T to G, chromosome 15 at 101,817,663 bp
  • A to G, chromosome 16 at 16,037,717 bp
  • A to G, chromosome 17 at 45,666,115 bp
  • T to C, chromosome 19 at 24,122,272 bp
  • T to C, chromosome 19 at 34,076,979 bp
  • C to T, chromosome 19 at 44,524,506 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0749 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038929-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.