Strain Name:
C57BL/6J-MtgxR0766Btlr/Mmmh
Stock Number:
038946-MU
Citation ID:
RRID:MMRRC_038946-MU
Other Names:
R0766 (G1), C57BL/6J-MtgxR0766Btlr
Major Collection:

Gene Information

Vcp
Name: valosin containing protein
Synonyms: p97/VCP, p97, AAA ATPase p97, CDC48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269523
Homologene: 5168
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20650
Homologene: 4911
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Zfp638
Name: zinc finger protein 638
Synonyms: Np220, Zfml
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18139
Homologene: 7447
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Zfp407
Name: zinc finger protein 407
Synonyms: LOC381139, LOC240469, 6430585N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, P400, Pcp1, wblo, Ip3r, IP3R1, opt, InsP3R type I, Itpr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: tbl, D130015N03Rik, 2810449H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Pwp1
Name: PWP1 homolog, endonuclein
Synonyms: 2310058A11Rik, 2610205J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103136
Homologene: 5129
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, D630001M17Rik, 4921513O20Rik, cI-46, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Klrg1
Name: killer cell lectin-like receptor subfamily G, member 1
Synonyms: 2F1-Ag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50928
HGNC: HGNC:6380
Homologene: 4244
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, b2b3491Clo, Mdnah5, Dnahc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78250
Homologene: 11258
Ttc30a2
Name: tetratricopeptide repeat domain 30A2
Synonyms: OTTMUSG00000015167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 620631
Homologene: 44342
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: Lba1, A230061D21Rik, C030048J01Rik, LOC235639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Vmn1r167
Name: vomeronasal 1 receptor 167
Synonyms: Gm6279
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 622032
Homologene: 128341
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Tex22
Name: testis expressed gene 22
Synonyms: Tep22, 1700028O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75671
Homologene: 84861
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: C230094A16Rik, 2900083P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237711
Homologene: 104282
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIba, GPIb-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69922
Homologene: 55966
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170720
Homologene: 11469
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Itih-2, Intin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Cdh15
Name: cadherin 15
Synonyms: Mcad, Cdh14, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70941
Homologene: 52843
Snai2
Name: snail family zinc finger 2
Synonyms: Slug, Slugh, Snail2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20583
VEGA: 16
Homologene: 31127
Otos
Name: otospiralin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 260301
Homologene: 16396
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Esd, Es-10, Es10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72016
Homologene: 45943
Mkx
Name: mohawk homeobox
Synonyms: Irxl1, 9430023B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 210719
Homologene: 72239
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 88,230,680 bp
  • A to C, chromosome 1 at 92,645,351 bp
  • T to A, chromosome 2 at 10,097,924 bp
  • A to T, chromosome 2 at 75,976,332 bp
  • T to C, chromosome 4 at 42,988,728 bp
  • A to T, chromosome 4 at 103,270,797 bp
  • C to T, chromosome 4 at 154,989,799 bp
  • T to C, chromosome 5 at 150,403,432 bp
  • A to G, chromosome 6 at 83,929,041 bp
  • A to G, chromosome 6 at 108,410,900 bp
  • T to C, chromosome 6 at 121,676,890 bp
  • T to C, chromosome 6 at 122,279,663 bp
  • A to G, chromosome 7 at 23,505,123 bp
  • G to A, chromosome 8 at 80,615,322 bp
  • A to G, chromosome 8 at 107,001,577 bp
  • G to A, chromosome 8 at 122,861,449 bp
  • G to A, chromosome 9 at 63,482,683 bp
  • C to T, chromosome 9 at 66,504,840 bp
  • T to G, chromosome 9 at 111,347,469 bp
  • G to A, chromosome 10 at 85,879,309 bp
  • G to A, chromosome 11 at 23,757,010 bp
  • G to A, chromosome 11 at 26,535,522 bp
  • A to T, chromosome 11 at 29,173,358 bp
  • A to G, chromosome 11 at 29,831,219 bp
  • T to A, chromosome 11 at 30,807,687 bp
  • C to T, chromosome 11 at 70,641,427 bp
  • T to C, chromosome 11 at 119,324,176 bp
  • A to G, chromosome 12 at 113,088,523 bp
  • T to C, chromosome 14 at 33,140,612 bp
  • T to C, chromosome 14 at 74,742,121 bp
  • A to C, chromosome 15 at 28,448,487 bp
  • A to G, chromosome 15 at 91,699,895 bp
  • T to A, chromosome 16 at 14,708,247 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • T to A, chromosome 18 at 6,937,192 bp
  • C to T, chromosome 18 at 84,559,773 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0766 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038946-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.