Strain Name:
C57BL/6J-MtgxR0780Btlr/Mmmh
Stock Number:
038960-MU
Citation ID:
RRID:MMRRC_038960-MU
Other Names:
R0780 (G1), C57BL/6J-MtgxR0780Btlr
Major Collection:

Gene Information

Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 171286
Homologene: 11628
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Zfand6
Name: zinc finger, AN1-type domain 6
Synonyms: 3110005P07Rik, Za20d3, Awp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 65098
Homologene: 10372
Ccdc163
Name: coiled-coil domain containing 163
Synonyms: 4933430J04Rik, 0610037D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68394
Homologene: 12265
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: Ube1c, ubiquitin activating enzyme 3, A830034N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22200
Homologene: 2951
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107182
Homologene: 31978
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Lifr
Name: LIF receptor alpha
Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Mtmr4
Name: myotubularin related protein 4
Synonyms: ZFYVE11, FYVE-DSP2, FYVE zinc finger phosphatase, ESTM44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Ahsa1
Name: AHA1, activator of heat shock protein ATPase 1
Synonyms: Aha1, p38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217737
VEGA: 12
HGNC: HGNC:1189
Homologene: 8106
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: A2mr, CD91, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Ifi208
Name: interferon activated gene 208
Synonyms: Pyr-rv1, Pydc3, E430029J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546913
Homologene: 84037
Ica1l
Name: islet cell autoantigen 1-like
Synonyms: b2b3465Clo, 1700030B17Rik, Als2cr15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70375
Homologene: 16323
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Cxcr2
Name: chemokine (C-X-C motif) receptor 2
Synonyms: IL-8rb, Cmkar2, IL8RA, CD128, Gpcr16, IL-8Rh, Il8rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12765
HGNC: HGNC:6027
Homologene: 10439
Ptgds
Name: prostaglandin D2 synthase (brain)
Synonyms: PGD2, L-PGDS, Ptgs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19215
HGNC: HGNC:9592
Homologene: 737
Olfr286
Name: olfactory receptor 286
Synonyms: MOR286-2, EG629524, GA_x6K02T2NBG7-5528233-5529186
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 629524
Homologene: 134078
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 59,997,449 bp
  • T to A, chromosome 1 at 74,159,175 bp
  • T to A, chromosome 1 at 150,431,341 bp
  • A to G, chromosome 1 at 173,682,696 bp
  • G to A, chromosome 2 at 13,456,613 bp
  • A to G, chromosome 2 at 25,468,092 bp
  • A to G, chromosome 4 at 116,712,407 bp
  • C to A, chromosome 5 at 75,185,944 bp
  • G to T, chromosome 5 at 124,750,812 bp
  • C to T, chromosome 5 at 137,290,532 bp
  • A to G, chromosome 6 at 12,337,274 bp
  • G to A, chromosome 6 at 97,186,705 bp
  • A to T, chromosome 6 at 123,637,974 bp
  • T to A, chromosome 7 at 84,615,834 bp
  • A to G, chromosome 10 at 127,568,729 bp
  • T to A, chromosome 11 at 87,611,440 bp
  • A to G, chromosome 11 at 113,893,508 bp
  • T to A, chromosome 12 at 71,947,050 bp
  • T to C, chromosome 12 at 87,268,328 bp
  • A to T, chromosome 14 at 57,691,296 bp
  • A to G, chromosome 14 at 64,030,351 bp
  • C to T, chromosome 15 at 7,177,466 bp
  • A to G, chromosome 15 at 76,600,377 bp
  • A to G, chromosome 15 at 98,226,982 bp
  • G to T, chromosome 15 at 98,862,857 bp
  • G to A, chromosome 16 at 33,646,665 bp
  • T to A, chromosome 17 at 53,567,448 bp
  • T to C, chromosome 19 at 36,988,922 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0780 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038960-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.