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Strain Name:
C57BL/6J-MtgxR0792Btlr/Mmmh
Stock Number:
038972-MU
Citation ID:
RRID:MMRRC_038972-MU
Other Names:
R0792 (G1), C57BL/6J-MtgxR0792Btlr
Major Collection:

Strain Information

Bdnf
Name: brain derived neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12064
HGNC: HGNC:1033
Homologene: 7245
Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Glt8d1
Name: glycosyltransferase 8 domain containing 1
Synonyms: 5430414N14Rik, 2410004H05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76485
VEGA: 14
Homologene: 32720
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 13,125,744 bp
  • A to T, chromosome 1 at 16,102,679 bp
  • A to T, chromosome 1 at 58,903,661 bp
  • C to A, chromosome 1 at 153,234,580 bp
  • T to G, chromosome 1 at 153,234,595 bp
  • T to C, chromosome 1 at 153,234,612 bp
  • C to T, chromosome 1 at 162,920,563 bp
  • A to G, chromosome 1 at 172,071,505 bp
  • T to A, chromosome 2 at 35,155,279 bp
  • G to A, chromosome 2 at 109,724,118 bp
  • A to T, chromosome 2 at 130,600,710 bp
  • G to T, chromosome 2 at 154,165,619 bp
  • G to T, chromosome 2 at 156,077,419 bp
  • A to G, chromosome 3 at 36,164,562 bp
  • T to C, chromosome 4 at 45,927,975 bp
  • T to A, chromosome 4 at 101,102,950 bp
  • T to C, chromosome 4 at 148,462,910 bp
  • A to G, chromosome 5 at 32,828,423 bp
  • T to C, chromosome 6 at 41,458,944 bp
  • T to C, chromosome 6 at 56,886,749 bp
  • C to T, chromosome 6 at 113,773,388 bp
  • A to G, chromosome 7 at 23,702,735 bp
  • G to T, chromosome 7 at 27,325,060 bp
  • A to G, chromosome 7 at 108,668,157 bp
  • A to G, chromosome 7 at 134,874,150 bp
  • G to A, chromosome 7 at 141,639,559 bp
  • A to T, chromosome 8 at 36,938,548 bp
  • G to A, chromosome 10 at 39,105,132 bp
  • A to C, chromosome 10 at 43,022,693 bp
  • A to T, chromosome 10 at 80,708,479 bp
  • A to T, chromosome 10 at 127,332,577 bp
  • G to T, chromosome 10 at 127,567,364 bp
  • A to T, chromosome 10 at 127,575,286 bp
  • A to T, chromosome 11 at 20,240,652 bp
  • T to C, chromosome 11 at 65,896,001 bp
  • A to T, chromosome 11 at 70,220,631 bp
  • G to A, chromosome 11 at 115,250,646 bp
  • T to A, chromosome 11 at 116,227,723 bp
  • T to A, chromosome 12 at 104,151,546 bp
  • T to C, chromosome 13 at 4,194,112 bp
  • A to G, chromosome 13 at 100,283,766 bp
  • T to C, chromosome 13 at 119,430,318 bp
  • T to C, chromosome 14 at 31,011,241 bp
  • T to C, chromosome 14 at 88,123,168 bp
  • T to A, chromosome 15 at 6,486,762 bp
  • A to G, chromosome 15 at 74,580,617 bp
  • T to A, chromosome 15 at 83,628,076 bp
  • A to G, chromosome 15 at 85,931,276 bp
  • A to G, chromosome 15 at 101,816,497 bp
  • A to T, chromosome 16 at 59,303,989 bp
  • T to C, chromosome 17 at 21,819,528 bp
  • C to A, chromosome 17 at 24,948,673 bp
  • C to T, chromosome 17 at 34,242,614 bp
  • A to T, chromosome 17 at 71,121,136 bp
  • T to C, chromosome 17 at 74,415,645 bp
  • G to T, chromosome 19 at 9,016,734 bp
  • T to C, chromosome 19 at 45,010,254 bp
  • A to T, chromosome 19 at 45,933,868 bp
  • C to A, chromosome 19 at 48,706,009 bp
  • T to C, chromosome 19 at 55,280,492 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0792 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038972-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.