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Strain Name:
C57BL/6J-MtgxR0800Btlr/Mmmh
Stock Number:
038980-MU
Citation ID:
RRID:MMRRC_038980-MU
Other Names:
R0800 (G1), C57BL/6J-MtgxR0800Btlr
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Synonyms: G alpha q, Gq, Galphaq, 6230401I02Rik, 1110005L02Rik, Dsk10, Dsk1, GqI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14682
HGNC: HGNC:4390
Homologene: 1566
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, 2900005P22Rik, Nibp, TRS130, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: Aprf, 1110034C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20848
Homologene: 7960
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: VPARP, VAULT3, p193, PH5P, E230037B21Rik, Adprtl1, C030027K23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 20,777,953 bp
  • A to G, chromosome 1 at 42,698,367 bp
  • A to G, chromosome 1 at 53,565,696 bp
  • T to C, chromosome 1 at 75,423,489 bp
  • C to A, chromosome 1 at 90,142,731 bp
  • C to T, chromosome 1 at 162,876,814 bp
  • T to A, chromosome 1 at 164,066,201 bp
  • C to T, chromosome 1 at 173,184,060 bp
  • A to T, chromosome 2 at 12,193,551 bp
  • A to G, chromosome 2 at 89,325,664 bp
  • A to T, chromosome 2 at 126,630,328 bp
  • G to A, chromosome 2 at 130,143,422 bp
  • A to T, chromosome 2 at 148,830,327 bp
  • A to G, chromosome 2 at 156,045,663 bp
  • T to C, chromosome 3 at 92,825,035 bp
  • C to A, chromosome 3 at 96,719,311 bp
  • T to A, chromosome 3 at 131,599,854 bp
  • A to G, chromosome 4 at 45,882,797 bp
  • T to A, chromosome 4 at 57,709,650 bp
  • A to G, chromosome 4 at 152,356,157 bp
  • T to C, chromosome 5 at 35,075,289 bp
  • T to A, chromosome 5 at 109,427,326 bp
  • T to A, chromosome 6 at 52,556,505 bp
  • A to T, chromosome 6 at 131,230,174 bp
  • A to G, chromosome 7 at 25,285,237 bp
  • A to G, chromosome 7 at 115,579,014 bp
  • T to A, chromosome 8 at 105,085,269 bp
  • A to G, chromosome 8 at 105,913,606 bp
  • A to T, chromosome 9 at 7,357,827 bp
  • A to G, chromosome 9 at 108,495,154 bp
  • A to G, chromosome 10 at 17,799,492 bp
  • A to G, chromosome 10 at 59,403,820 bp
  • A to G, chromosome 11 at 29,749,877 bp
  • A to C, chromosome 11 at 32,287,581 bp
  • A to G, chromosome 11 at 69,825,997 bp
  • T to C, chromosome 11 at 94,426,439 bp
  • T to C, chromosome 11 at 97,841,260 bp
  • A to G, chromosome 11 at 100,894,155 bp
  • A to C, chromosome 11 at 114,866,711 bp
  • T to C, chromosome 11 at 121,512,012 bp
  • A to G, chromosome 14 at 54,953,278 bp
  • A to G, chromosome 14 at 56,132,491 bp
  • A to G, chromosome 14 at 56,589,951 bp
  • A to T, chromosome 14 at 70,409,037 bp
  • A to C, chromosome 15 at 57,822,728 bp
  • A to T, chromosome 15 at 72,953,132 bp
  • A to G, chromosome 16 at 48,953,808 bp
  • T to A, chromosome 17 at 26,923,184 bp
  • T to A, chromosome 17 at 30,704,662 bp
  • A to G, chromosome 17 at 33,926,253 bp
  • T to A, chromosome 19 at 8,928,908 bp
  • T to A, chromosome 19 at 16,335,064 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0800 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038980-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.