Strain Name:
C57BL/6J-MtgxR0840Btlr/Mmmh
Stock Number:
039019-MU
Citation ID:
RRID:MMRRC_039019-MU
Other Names:
R0840 (G1), C57BL/6J-MtgxR0840Btlr
Major Collection:

Gene Information

Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Stx1a
Name: syntaxin 1A (brain)
Synonyms: HPC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20907
Homologene: 37941
Fblim1
Name: filamin binding LIM protein 1
Synonyms: 2410043F08Rik, Cal, migfilin(s), migfilin, Fblp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74202
Homologene: 56774
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC155, RPC1, 9330175N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Ep300
Name: E1A binding protein p300
Synonyms: KAT3B, p300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328110
Homologene: 32377
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: Lrrc33, E430025L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224109
Homologene: 17134
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Ten-m3, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Pot1a
Name: protection of telomeres 1A
Synonyms: Pot1, 1500031H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101185
Homologene: 32263
Pgap2
Name: post-GPI attachment to proteins 2
Synonyms: 1810006G21Rik, Frag1, clpex
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233575
Homologene: 137653
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216742
Homologene: 28173
Fbxo46
Name: F-box protein 46
Synonyms: Fbxo34l, 20D7-FC4, 4932704E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243867
Homologene: 18467
Irf8
Name: interferon regulatory factor 8
Synonyms: Myls, ICSBP, IRF-8, Icsbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Cep295
Name: centrosomal protein 295
Synonyms: 5830418K08Rik, LOC382128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: 4732452O09Rik, Gpig4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320292
Homologene: 14860
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16532
Homologene: 7392
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Lpp2, Ppap2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235505
Homologene: 25183
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240069
Homologene: 18615
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Nrxn3
Name: neurexin III
Synonyms: neurexin III alpha, 4933401A11Rik, D12Bwg0831e, neurexin III beta, neurexin III beta, neurexin III alpha, 9330112C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Tmcc3
Name: transmembrane and coiled coil domains 3
Synonyms: A230066D03Rik, LOC380656, C630016B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319880
Homologene: 10792
Zfp882
Name: zinc finger protein 882
Synonyms: ENSMUSG00000052439
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382019
Homologene: 136303
Guk1
Name: guanylate kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14923
HGNC: HGNC:4693
Homologene: 665
Trim5
Name: tripartite motif-containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667823
Homologene: 75345
Olfr504
Name: olfactory receptor 504
Synonyms: MOR40-15, MOR40-7P, GA_x6K02T2PBJ9-10895499-10894543
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258163
Homologene: 17189
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
Zbtb3
Name: zinc finger and BTB domain containing 3
Synonyms: 4930563M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75291
VEGA: 19
Homologene: 23485
Mettl22
Name: methyltransferase like 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239706
Homologene: 16619
Tmem41b
Name: transmembrane protein 41B
Synonyms: 1500015G02Rik, 1500031M19Rik, D7Ertd70e, D7Ertd743e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233724
Homologene: 42740
Adra1a
Name: adrenergic receptor, alpha 1a
Synonyms: Adra1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11549
HGNC: HGNC:277
Homologene: 68078
Foxl2
Name: forkhead box L2
Synonyms: Pfrk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26927
HGNC: HGNC:1092
Homologene: 74992
Gm20671
Name: predicted gene 20671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
1810020O05Rik
Name: Riken cDNA 1810020O05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 613264
Bsg
Name: basigin
Synonyms: EMMPRIN, neurothelin, gp 42, CD147, HT-7, 5A11/Basigin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12215
HGNC: HGNC:1116
Homologene: 1308
Krt32
Name: keratin 32
Synonyms: Krt1-2, mHa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16670
HGNC: HGNC:6449
Homologene: 68246
Acot5
Name: acyl-CoA thioesterase 5
Synonyms: PTE-Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217698
Homologene: 77351
Olfr129
Name: olfactory receptor 129
Synonyms: GA_x6K02T2PSCP-2503741-2502776, MOR263-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258324
Homologene: 133641
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,350,521 bp
  • C to A, chromosome 2 at 34,729,113 bp
  • T to C, chromosome 2 at 76,786,811 bp
  • T to A, chromosome 2 at 119,326,485 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • A to G, chromosome 4 at 141,581,009 bp
  • A to G, chromosome 5 at 32,737,312 bp
  • T to C, chromosome 5 at 99,234,688 bp
  • T to A, chromosome 5 at 135,041,234 bp
  • T to C, chromosome 6 at 25,748,284 bp
  • G to T, chromosome 6 at 87,680,278 bp
  • A to G, chromosome 6 at 139,896,072 bp
  • T to A, chromosome 7 at 19,137,148 bp
  • A to T, chromosome 7 at 102,237,448 bp
  • A to T, chromosome 7 at 104,265,771 bp
  • A to T, chromosome 7 at 108,565,616 bp
  • G to A, chromosome 7 at 109,981,049 bp
  • T to A, chromosome 8 at 25,913,684 bp
  • C to A, chromosome 8 at 48,335,742 bp
  • C to A, chromosome 8 at 60,929,154 bp
  • T to A, chromosome 8 at 71,914,686 bp
  • G to A, chromosome 8 at 120,753,481 bp
  • A to T, chromosome 9 at 15,334,315 bp
  • T to C, chromosome 9 at 78,664,330 bp
  • A to T, chromosome 9 at 98,955,931 bp
  • A to G, chromosome 10 at 79,527,544 bp
  • A to G, chromosome 10 at 79,709,685 bp
  • A to G, chromosome 10 at 94,578,771 bp
  • C to T, chromosome 11 at 35,623,436 bp
  • T to A, chromosome 11 at 54,493,181 bp
  • G to A, chromosome 11 at 59,185,095 bp
  • G to A, chromosome 11 at 100,081,242 bp
  • T to G, chromosome 12 at 65,048,206 bp
  • C to G, chromosome 12 at 71,158,883 bp
  • G to A, chromosome 12 at 84,075,840 bp
  • A to G, chromosome 12 at 90,331,793 bp
  • T to C, chromosome 13 at 64,787,910 bp
  • G to A, chromosome 14 at 24,452,200 bp
  • T to A, chromosome 14 at 56,475,447 bp
  • A to G, chromosome 14 at 66,727,710 bp
  • A to G, chromosome 15 at 39,876,158 bp
  • A to T, chromosome 15 at 80,358,949 bp
  • A to T, chromosome 15 at 81,644,933 bp
  • T to C, chromosome 16 at 8,482,157 bp
  • T to C, chromosome 16 at 21,456,321 bp
  • T to C, chromosome 16 at 32,143,423 bp
  • G to T, chromosome 17 at 33,136,112 bp
  • A to G, chromosome 17 at 38,055,572 bp
  • T to A, chromosome 19 at 5,685,701 bp
  • T to A, chromosome 19 at 8,803,457 bp
  • T to A, chromosome 19 at 9,005,063 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0840 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039019-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.