Strain Name:
C57BL/6J-MtgxR0845Btlr/Mmmh
Stock Number:
039024-MU
Citation ID:
RRID:MMRRC_039024-MU
Other Names:
R0845 (G1), C57BL/6J-MtgxR0845Btlr
Major Collection:

Gene Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p55alpha, p85alpha, p50alpha, PI3K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Fnra, Cd49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227738
Homologene: 44526
Brd7
Name: bromodomain containing 7
Synonyms: BP75, CELTIX1, bromodomain protein 75 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26992
Homologene: 8085
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 5730522G15Rik, Ht31, 5830460E08Rik, PROTO-LB, PROTO-LBC, AKAP-Lbc, 1700026G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Larp1
Name: La ribonucleoprotein domain family, member 1
Synonyms: Larp, 1810024J12Rik, 3110040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73158
Homologene: 9089
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Xpo6
Name: exportin 6
Synonyms: Ranbp20, 2610005L19Rik, C230091E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Dhx16
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 16
Synonyms: DBP2, 2410006N22Rik, Ddx16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Phf11d
Name: PHD finger protein 11D
Synonyms: D14Ertd668e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219132
Homologene: 87807
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, D630001M17Rik, 4921513O20Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Tmem131
Name: transmembrane protein 131
Synonyms: Rw1, Neg, 2610524E03Rik, D1Bwg0491e, YR-23, CC28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Gdh-X, Glud
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14661
HGNC: HGNC:4335
Homologene: 55885
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Septin9
Name: septin 9
Synonyms: Msf, MSF1, PNUTL4, Sint1, Sept9, SL3-3 integration site 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Serinc1
Name: serine incorporator 1
Synonyms: Tde2, 1500011D18Rik, Tde1l, TMS-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56442
Homologene: 41334
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105351
VEGA: 13
Homologene: 11439
Zfp667
Name: zinc finger protein 667
Synonyms: A830025F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384763
Homologene: 23343
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: Qed-1, T23b, 37c, 37b, T18c, T23d, Qa1, H-2T23, T18c(37), Qa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Gnb1l
Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms: Me49f07, Wdvcf, Wdr14, ESTM55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13972
HGNC: HGNC:4397
Homologene: 41515
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola-2, Col1a-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Adamtsl3
Name: ADAMTS-like 3
Synonyms: 9230119C12Rik, punctin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269959
Homologene: 18912
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, 4832426G23Rik, Myhs-p, MyHC-pn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: OTTMUSG00000020804, ENSMUSG00000044873, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: D930008O12Rik, Ncx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242341
Homologene: 72090
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Tcn2
Name: transcobalamin 2
Synonyms: Tcn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21452
Homologene: 303
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: nSR100, bv, 1500001A10Rik, B230202K19Rik, flopsy, fp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68955
Homologene: 49869
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433809
Homologene: 19234
Msln
Name: mesothelin
Synonyms: megakaryocyte potentiating factor, MPF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Clstn2
Name: calsyntenin 2
Synonyms: CSTN2, 2900042C18Rik, CS2, Cst-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64085
Homologene: 49698
Pih1d1
Name: PIH1 domain containing 1
Synonyms: 1110061L23Rik, 4933413A04Rik, Nop17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68845
Homologene: 9914
Mup21
Name: major urinary protein 21
Synonyms: Gm11208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381531
Homologene: 74304
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
Paqr9
Name: progestin and adipoQ receptor family member IX
Synonyms: 1700020G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75552
Homologene: 18882
Gm8220
Name: predicted gene 8220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 666660
Homologene: 128452
Comt
Name: catechol-O-methyltransferase
Synonyms: D330014B15Rik, D16Wsu103e, Comt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12846
HGNC: HGNC:2228
Homologene: 30982
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,816,222 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • C to T, chromosome 2 at 32,953,443 bp
  • A to G, chromosome 2 at 118,609,976 bp
  • A to G, chromosome 3 at 122,729,331 bp
  • T to A, chromosome 3 at 146,455,107 bp
  • C to T, chromosome 4 at 19,880,055 bp
  • A to G, chromosome 4 at 62,150,310 bp
  • A to G, chromosome 4 at 152,312,064 bp
  • C to T, chromosome 5 at 116,444,885 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • A to T, chromosome 7 at 6,306,092 bp
  • G to T, chromosome 7 at 28,913,430 bp
  • A to G, chromosome 7 at 45,159,682 bp
  • T to G, chromosome 7 at 75,725,380 bp
  • A to G, chromosome 7 at 82,575,996 bp
  • G to T, chromosome 7 at 104,142,068 bp
  • G to A, chromosome 7 at 126,129,543 bp
  • A to G, chromosome 7 at 141,850,446 bp
  • A to T, chromosome 8 at 88,342,767 bp
  • T to C, chromosome 9 at 95,560,740 bp
  • T to A, chromosome 9 at 97,570,628 bp
  • A to T, chromosome 10 at 57,525,383 bp
  • T to A, chromosome 11 at 3,919,349 bp
  • A to G, chromosome 11 at 58,047,750 bp
  • T to C, chromosome 11 at 67,286,264 bp
  • T to C, chromosome 11 at 73,165,574 bp
  • T to C, chromosome 11 at 117,356,325 bp
  • T to C, chromosome 12 at 103,173,444 bp
  • T to G, chromosome 13 at 14,637,022 bp
  • G to T, chromosome 13 at 101,686,264 bp
  • A to G, chromosome 14 at 34,329,394 bp
  • A to G, chromosome 14 at 44,286,791 bp
  • A to T, chromosome 14 at 59,353,344 bp
  • T to C, chromosome 15 at 55,563,090 bp
  • C to A, chromosome 15 at 91,755,962 bp
  • T to A, chromosome 15 at 103,350,769 bp
  • T to C, chromosome 16 at 18,407,961 bp
  • A to G, chromosome 16 at 18,552,473 bp
  • T to C, chromosome 17 at 25,750,796 bp
  • T to C, chromosome 17 at 35,883,302 bp
  • T to C, chromosome 17 at 36,030,583 bp
  • A to G, chromosome 17 at 81,437,748 bp
  • T to C, chromosome 18 at 49,893,402 bp
  • T to C, chromosome 19 at 5,465,461 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0845 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039024-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.