Strain Name:
C57BL/6J-MtgxR0846Btlr/Mmmh
Stock Number:
039025-MU
Citation ID:
RRID:MMRRC_039025-MU
Other Names:
R0846 (G1), C57BL/6J-MtgxR0846Btlr
Major Collection:

Gene Information

Ccn1
Name: cellular communication network factor 1
Synonyms: CCN1, Cyr61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16007
HGNC: HGNC:2654
Homologene: 1194
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Fos
Name: FBJ osteosarcoma oncogene
Synonyms: c-fos, D12Rfj1, cFos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14281
HGNC: HGNC:3796
Homologene: 3844
Pdxdc1
Name: pyridoxal-dependent decarboxylase domain containing 1
Synonyms: 2210010A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94184
Homologene: 22858
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Cop1, Rfwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26374
Homologene: 115565
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20019
Homologene: 7033
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Cap1
Name: CAP, adenylate cyclase-associated protein 1 (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12331
Homologene: 74572
Mnat1
Name: menage a trois 1
Synonyms: MAT1, E130115E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Klf4
Name: Kruppel-like factor 4 (gut)
Synonyms: Gklf, Zie, EZF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16600
HGNC: HGNC:6348
Homologene: 3123
Dcc
Name: deleted in colorectal carcinoma
Synonyms: C030036D22Rik, Igdcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Scamp4
Name: secretory carrier membrane protein 4
Synonyms: Sc4, 2410022D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56214
VEGA: 10
Homologene: 10476
Slc17a8
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Synonyms: Vglut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216227
Homologene: 13584
Adh5
Name: alcohol dehydrogenase 5 (class III), chi polypeptide
Synonyms: Adh-5, Adh3, S-nitrosoglutathione reductase, GSNOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11532
HGNC: HGNC:253
Homologene: 68076
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269774
Homologene: 128746
Tm7sf3
Name: transmembrane 7 superfamily member 3
Synonyms: 2010003B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67623
Homologene: 9560
Gorasp2
Name: golgi reassembly stacking protein 2
Synonyms: GRASP55, 5730520M13Rik, 9430094F20Rik, GOLPH2, GRS2, p59, ENSMUSG00000075299
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70231
Homologene: 9180
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Mek4, Hek4, Hek, Cek4, End3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b1203Clo, b2b1279Clo, b2b598Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Sync
Name: syncoilin
Synonyms: SNIP4, 1110057H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68828
Homologene: 11351
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Pramel19
Name: PRAME like 19
Synonyms: Gm12794
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 332923
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76795
Homologene: 28106
Gal3st2c
Name: galactose-3-O-sulfotransferase 2C
Synonyms: Gm6086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619597
Homologene: 41471
Fsd2
Name: fibronectin type III and SPRY domain containing 2
Synonyms: Spryd1, 9830160G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244091
Homologene: 18252
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: HD, MFP, L-bifunctional enzyme, L-PBE, 1300002P22Rik, MFP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Olfr1036
Name: olfactory receptor 1036
Synonyms: GA_x6K02T2Q125-47549689-47550621, MOR245-25, MOR262-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258245
1110051M20Rik
Name: RIKEN cDNA 1110051M20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228356
Homologene: 11471
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319876
Homologene: 8933
Vmn1r47
Name: vomeronasal 1 receptor 47
Synonyms: V1ra4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113846
Homologene: 137651
Fitm2
Name: fat storage-inducing transmembrane protein 2
Synonyms: Fit2, D930001I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228859
Homologene: 35254
Zfp773
Name: zinc finger protein 773
Synonyms: 2810409K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76373
Homologene: 137393
Cdo1
Name: cysteine dioxygenase 1, cytosolic
Synonyms: Cdo, D18Ucla3, 1300002L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12583
VEGA: 18
HGNC: HGNC:1795
Homologene: 1365
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353025
Homologene: 72278
Ldc1
Name: leucine decarboxylase 1
Synonyms: LOC332942, Gm853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 332942
Homologene: 128653
Atg4d
Name: autophagy related 4D, cysteine peptidase
Synonyms: APG4-D, 9830134P12Rik, Autl4, Apg4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235040
VEGA: 9
Homologene: 13156
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 94,006,947 bp
  • T to C, chromosome 1 at 159,319,816 bp
  • T to C, chromosome 2 at 65,102,065 bp
  • C to T, chromosome 2 at 66,324,755 bp
  • C to T, chromosome 2 at 66,697,600 bp
  • T to A, chromosome 2 at 70,690,954 bp
  • T to C, chromosome 2 at 86,075,166 bp
  • T to A, chromosome 2 at 91,383,837 bp
  • T to C, chromosome 2 at 163,469,814 bp
  • T to G, chromosome 3 at 138,451,074 bp
  • T to A, chromosome 3 at 145,647,770 bp
  • G to A, chromosome 4 at 55,530,191 bp
  • A to T, chromosome 4 at 101,941,250 bp
  • A to C, chromosome 4 at 122,862,899 bp
  • A to G, chromosome 4 at 129,294,104 bp
  • A to C, chromosome 4 at 130,221,624 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to C, chromosome 6 at 71,924,643 bp
  • T to C, chromosome 6 at 86,959,089 bp
  • T to A, chromosome 6 at 90,022,675 bp
  • G to A, chromosome 6 at 146,626,083 bp
  • A to T, chromosome 7 at 7,132,692 bp
  • T to C, chromosome 7 at 81,540,397 bp
  • G to T, chromosome 9 at 21,267,090 bp
  • T to C, chromosome 10 at 80,614,703 bp
  • T to C, chromosome 10 at 89,606,734 bp
  • T to G, chromosome 10 at 107,772,296 bp
  • G to A, chromosome 10 at 112,215,585 bp
  • A to C, chromosome 11 at 50,171,321 bp
  • T to G, chromosome 12 at 73,123,932 bp
  • C to T, chromosome 12 at 85,475,683 bp
  • A to G, chromosome 12 at 111,627,224 bp
  • G to T, chromosome 12 at 117,933,850 bp
  • G to A, chromosome 13 at 81,479,742 bp
  • T to C, chromosome 15 at 44,495,597 bp
  • A to C, chromosome 16 at 13,854,393 bp
  • T to C, chromosome 16 at 13,859,945 bp
  • G to T, chromosome 16 at 21,773,497 bp
  • G to A, chromosome 16 at 63,772,902 bp
  • A to G, chromosome 18 at 46,715,745 bp
  • A to G, chromosome 18 at 71,826,212 bp
  • T to C, chromosome 19 at 44,091,028 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039025-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.