Strain Name:
C57BL/6J-MtgxR0850Btlr/Mmmh
Stock Number:
039029-MU
Citation ID:
RRID:MMRRC_039029-MU
Other Names:
R0850 (G1), C57BL/6J-MtgxR0850Btlr
Major Collection:

Gene Information

Slc25a1tm1a(EUCOMM)Wtsi
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Elavl3
Name: ELAV like RNA binding protein 3
Synonyms: 2600009P04Rik, Huc, mHuC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 15571
VEGA: 9
HGNC: HGNC:3314
Homologene: 31035
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Tmed10
Name: transmembrane p24 trafficking protein 10
Synonyms: 1110014C03Rik, p23, p24delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68581
VEGA: 12
Homologene: 4972
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224273
Homologene: 28544
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: 4833427P12Rik, LOC381568, E330024L24Rik, Riz, KMT8, Riz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 117599
Homologene: 50463
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, jdf2, D7H15F37S1, rjs, D15F32S1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: Rbm16, A930036P18Rik, A630086M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106583
VEGA: 17
Homologene: 8928
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Dmp1
Name: dentin matrix protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13406
HGNC: HGNC:2932
Homologene: 68396
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74044
Homologene: 37826
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 2210416H12Rik, 4932415O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226999
Homologene: 20661
Med17
Name: mediator complex subunit 17
Synonyms: Crsp6, C330002H14Rik, Trap80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Pld1
Name: phospholipase D1
Synonyms: Pld1a, Pld1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Fbxo44
Name: F-box protein 44
Synonyms: FBX30, FBG3, Fbxo6a, Fbx6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230903
Homologene: 13232
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 4930431N21Rik, Ccp3, 2900053G10Rik, 6530406M24Rik, Ccp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76223
Homologene: 35330
9330182L06Rik
Name: RIKEN cDNA 9330182L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231014
Homologene: 27396
Gypa
Name: glycophorin A
Synonyms: CD235a, GPA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14934
HGNC: HGNC:4702
Homologene: null
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627132
HGNC: null
Homologene: 129750
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Gm5538
Name: predicted gene 5538
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 433597
HGNC: null
Homologene: 79018
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
Synonyms: ENT4, mPMAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243328
Homologene: 71345
CT025661.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: DAGK7, Dgk theta, 110kDa, Dgkd, Dagk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Adcyap1r1
Name: adenylate cyclase activating polypeptide 1 receptor 1
Synonyms: PAC1R, PACAP1-R, 2900024I10Rik, PAC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11517
HGNC: HGNC:242
Homologene: 870
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 286942
Homologene: 17709
Herc6
Name: hect domain and RLD 6
Synonyms: CEB1, 4930427L17Rik, Herc5, 1700121D12Rik, 2510038N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67138
Homologene: 70768
Tmem45a2
Name: transmembrane protein 45A2
Synonyms: 2310005G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 69457
VEGA: 16
HGNC: null
Homologene: 131266
Olfr643
Name: olfactory receptor 643
Synonyms: MOR13-2, GA_x6K02T2PBJ9-6793628-6792684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259081
HGNC: null
Homologene: 17491
Ptprb
Name: protein tyrosine phosphatase, receptor type, B
Synonyms: 3230402H02Rik, VE-PTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54367
Homologene: 10297
Hspa1l
Name: heat shock protein 1-like
Synonyms: 70kDa, Msh5, Hsc70t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15482
HGNC: HGNC:5234
Homologene: 135835
Kcna7
Name: potassium voltage-gated channel, shaker-related subfamily, member 7
Synonyms: Kv1.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16495
HGNC: HGNC:6226
Homologene: 7791
Coq9
Name: coenzyme Q9
Synonyms: 2310005O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67914
Homologene: 6477
H2-DMb1
Name: histocompatibility 2, class II, locus Mb1
Synonyms: H2-Mb1, H2-M beta1, H-2Mb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14999
HGNC: HGNC:4935
Homologene: 68231
Mrps15
Name: mitochondrial ribosomal protein S15
Synonyms: 1500003E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66407
Homologene: 32636
4930433I11Rik
Name: RIKEN cDNA 4930433I11 gene
Synonyms: LOC243944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243944
HGNC: null
Homologene: 77912
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 211798
Homologene: 13100
Olfr790
Name: olfactory receptor 790
Synonyms: GA_x6K02T2PULF-11179777-11180721, MOR112-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258935
Homologene: 74101
1700016C15Rik
Name: RIKEN cDNA 1700016C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 69428
Homologene: 19111
Gm8325
Name: predicted pseudogene 8325
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 666853
HGNC: null
Homologene: null
4930597O21Rik
Name: RIKEN cDNA 4930597O21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Slc25a1
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
Synonyms: Slc20a3, 2610100G11Rik, 1300019P08Rik, Dgsj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13358
Homologene: 4362
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,718,581 bp
  • G to T, chromosome 1 at 40,784,362 bp
  • T to C, chromosome 1 at 46,224,594 bp
  • A to G, chromosome 1 at 177,741,005 bp
  • A to T, chromosome 3 at 28,049,200 bp
  • T to G, chromosome 3 at 59,752,248 bp
  • A to T, chromosome 3 at 60,877,348 bp
  • G to T, chromosome 3 at 100,947,572 bp
  • A to G, chromosome 4 at 123,474,402 bp
  • A to G, chromosome 4 at 126,048,686 bp
  • T to C, chromosome 4 at 143,132,203 bp
  • C to G, chromosome 4 at 148,156,269 bp
  • T to A, chromosome 5 at 9,417,993 bp
  • A to T, chromosome 5 at 104,212,787 bp
  • A to G, chromosome 5 at 105,878,797 bp
  • A to G, chromosome 5 at 108,654,578 bp
  • T to C, chromosome 5 at 142,718,572 bp
  • T to A, chromosome 6 at 34,799,204 bp
  • G to A, chromosome 6 at 55,475,457 bp
  • T to C, chromosome 6 at 57,583,242 bp
  • T to C, chromosome 6 at 66,896,194 bp
  • A to T, chromosome 7 at 40,993,056 bp
  • T to C, chromosome 7 at 45,409,431 bp
  • C to A, chromosome 7 at 56,204,483 bp
  • T to A, chromosome 7 at 104,059,045 bp
  • A to G, chromosome 8 at 80,496,345 bp
  • A to T, chromosome 8 at 94,842,775 bp
  • C to T, chromosome 9 at 15,267,407 bp
  • T to G, chromosome 9 at 22,036,763 bp
  • T to G, chromosome 9 at 66,466,670 bp
  • T to C, chromosome 9 at 109,649,617 bp
  • A to T, chromosome 10 at 116,302,125 bp
  • T to C, chromosome 10 at 116,339,510 bp
  • T to C, chromosome 10 at 120,105,367 bp
  • T to C, chromosome 10 at 129,501,724 bp
  • A to G, chromosome 11 at 87,797,502 bp
  • C to A, chromosome 11 at 114,780,787 bp
  • A to G, chromosome 12 at 85,343,505 bp
  • A to T, chromosome 16 at 17,927,281 bp
  • T to A, chromosome 16 at 57,045,369 bp
  • A to C, chromosome 16 at 59,544,021 bp
  • A to G, chromosome 17 at 3,195,774 bp
  • C to A, chromosome 17 at 18,305,017 bp
  • T to C, chromosome 17 at 34,155,562 bp
  • A to G, chromosome 17 at 34,977,623 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0850 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039029-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.