Strain Name:
C57BL/6J-MtgxR0853Btlr/Mmmh
Stock Number:
039032-MU
Citation ID:
RRID:MMRRC_039032-MU
Other Names:
R0853 (G1), C57BL/6J-MtgxR0853Btlr
Major Collection:

Gene Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Tsk2, Tsk-2, Col3a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-alpha, Frabin-gamma, Frabin-beta, ZFYVE6, Frabin, 9330209B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224014
Homologene: 26727
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: MOF, D7Ertd629e, 2010203C02Rik, 5830450F21Rik, Myst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67773
Homologene: 41676
Kpnb1
Name: karyopherin (importin) beta 1
Synonyms: Impnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: Pdzgef2, PDZ-GEF2, RA-GEF-2, C030018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192786
Homologene: 22968
Tubgcp5
Name: tubulin, gamma complex associated protein 5
Synonyms: GCP5, B130010C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233276
Homologene: 14172
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: 4921509N21Rik, 2810481F14Rik, SCAN1, E430034L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104884
Homologene: 5424
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 9830127L17Rik, 2810417M16Rik, 2700078E11Rik, D130033C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 78832
VEGA: 19
Homologene: 17821
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: A230108M10Rik, p63, mTAFI68, 4930408G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 21340
VEGA: 12
Homologene: 31331
Asb6
Name: ankyrin repeat and SOCS box-containing 6
Synonyms: 2510004M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 72323
Homologene: 9895
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 2900054P12Rik, 1700012P13Rik, Gcap14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 72972
Homologene: 10367
Amotl1
Name: angiomotin-like 1
Synonyms: JEAP, 2310067L22Rik, 4932416D09Rik, 2310010G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75723
Homologene: 43977
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms: Kir3.1, Kcnf3, GIRK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16519
HGNC: HGNC:6264
Homologene: 1687
Pah
Name: phenylalanine hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18478
HGNC: HGNC:8582
Homologene: 234
Cldn6
Name: claudin 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54419
HGNC: HGNC:2048
Homologene: 10300
Hk1
Name: hexokinase 1
Synonyms: Hk1-s, mHk1-s, Hk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Vezf1
Name: vascular endothelial zinc finger 1
Synonyms: db1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22344
Homologene: 5175
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: pcy, nephrocystin 3, 3632410F03Rik, D330020E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93875
Homologene: 62176
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, CD169, Siglec-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20612
Homologene: 124458
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Leprel2, Grcb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14789
Homologene: 8401
Gckr
Name: glucokinase regulatory protein
Synonyms: GKRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231103
HGNC: HGNC:4196
Homologene: 1139
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Birc1b, Naip-rs6, Naip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: NRH: quinone oxidoreductase, Ox2, Ox-2, Nmor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V3R4, V1rd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 81014
Homologene: 41799
Angpt4
Name: angiopoietin 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11602
HGNC: HGNC:487
Homologene: 36302
Atxn7
Name: ataxin 7
Synonyms: ataxin-7, Sca7, A430107N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 246103
VEGA: 14
Homologene: 30967
Klra8
Name: killer cell lectin-like receptor, subfamily A, member 8
Synonyms: Cmv1, Ly49u129, Cmv-1, Ly49h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16639
Homologene: 110821
Fam118a
Name: family with sequence similarity 118, member A
Synonyms: C230014M12Rik, 3110048E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73225
VEGA: 15
HGNC: HGNC:1313
Homologene: 9911
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas1, Sas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: C2GNT3, LOC218476, Gm73, LOC238786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218476
VEGA: 13
Homologene: 41144
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, wl, Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50769
Homologene: 4443
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: Hyal-ps1, 4932701A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: 1700042J16Rik, A730034A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209462
Homologene: 10807
Gm10749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Ralyl
Name: RALY RNA binding protein-like
Synonyms: 0710005M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76897
Homologene: 18366
Gm10109
Name: predicted gene 10109
Synonyms: EG638411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 638411
Tbx20
Name: T-box 20
Synonyms: Tbx12, 9430010M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 57246
VEGA: 9
Homologene: 32476
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 45,343,324 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • T to A, chromosome 1 at 140,105,490 bp
  • G to A, chromosome 2 at 30,827,030 bp
  • T to C, chromosome 2 at 55,437,223 bp
  • G to A, chromosome 2 at 131,085,022 bp
  • A to T, chromosome 2 at 150,255,478 bp
  • A to G, chromosome 2 at 151,938,927 bp
  • A to G, chromosome 3 at 13,946,506 bp
  • G to C, chromosome 5 at 31,305,048 bp
  • T to C, chromosome 6 at 24,734,073 bp
  • T to C, chromosome 6 at 58,876,564 bp
  • G to T, chromosome 6 at 124,854,933 bp
  • T to C, chromosome 6 at 130,119,014 bp
  • G to T, chromosome 7 at 5,410,325 bp
  • T to A, chromosome 7 at 44,221,498 bp
  • T to A, chromosome 7 at 55,814,851 bp
  • C to T, chromosome 7 at 127,925,224 bp
  • G to T, chromosome 9 at 14,592,778 bp
  • A to G, chromosome 9 at 24,725,612 bp
  • T to C, chromosome 9 at 104,031,933 bp
  • T to A, chromosome 10 at 45,648,683 bp
  • T to A, chromosome 10 at 62,271,716 bp
  • G to A, chromosome 10 at 87,576,218 bp
  • T to A, chromosome 11 at 54,668,677 bp
  • A to T, chromosome 11 at 88,068,435 bp
  • T to A, chromosome 11 at 88,068,436 bp
  • T to C, chromosome 11 at 97,187,411 bp
  • G to A, chromosome 11 at 113,821,415 bp
  • T to C, chromosome 12 at 24,514,828 bp
  • G to A, chromosome 12 at 99,935,067 bp
  • A to T, chromosome 13 at 33,979,577 bp
  • A to G, chromosome 13 at 96,946,835 bp
  • T to C, chromosome 13 at 100,161,854 bp
  • C to T, chromosome 13 at 100,161,860 bp
  • C to A, chromosome 14 at 14,089,465 bp
  • A to C, chromosome 14 at 36,940,410 bp
  • T to C, chromosome 14 at 59,860,270 bp
  • T to C, chromosome 15 at 85,048,525 bp
  • T to A, chromosome 16 at 16,474,387 bp
  • T to G, chromosome 17 at 23,681,464 bp
  • T to G, chromosome 18 at 37,309,885 bp
  • C to A, chromosome 18 at 61,080,327 bp
  • C to A, chromosome 19 at 29,284,926 bp
  • A to T, chromosome 19 at 60,534,226 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0853 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039032-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.