Strain Name:
C57BL/6J-MtgxR0855Btlr/Mmmh
Stock Number:
039034-MU
Citation ID:
RRID:MMRRC_039034-MU
Other Names:
R0855 (G1), C57BL/6J-MtgxR0855Btlr
Major Collection:

Strain Information

Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, NMHC II-B, Myhn2, Myosin IIB, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Ppp2ca
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms: PP2A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19052
HGNC: HGNC:9299
Homologene: 37660
Picalm
Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: fit-1, fit1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233489
Homologene: 111783
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, E430018P19Rik, 8030453L17Rik, KMT2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Sars1
Name: seryl-tRNA synthetase 1
Synonyms: Strs, Sars
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20226
Homologene: 4751
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: Blzf1l, Jem-1, 1700030G05Rik, Golgin-45
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Prdm14
Name: PR domain containing 14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383491
Homologene: 11556
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Kcnk7
Name: potassium channel, subfamily K, member 7
Synonyms: Mlk3, Knot, Kcnk8, 2310014G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16530
HGNC: HGNC:6282
Homologene: 43131
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Btn1a1
Name: butyrophilin, subfamily 1, member A1
Synonyms: Btn
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12231
HGNC: HGNC:1135
Homologene: 1312
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Ak3
Name: adenylate kinase 3
Synonyms: AK-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56248
Homologene: 21744
Smtn
Name: smoothelin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29856
Homologene: 8482
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Mrpl54
Name: mitochondrial ribosomal protein L54
Synonyms: 0610008M19Rik, D10Sut1e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66047
Homologene: 11910
Ndufaf6
Name: NADH:ubiquinone oxidoreductase complex assembly factor 6
Synonyms: 2310030N02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76947
Homologene: 43831
Tbx20
Name: T-box 20
Synonyms: Tbx12, 9430010M06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57246
VEGA: 9
Homologene: 32476
Cnksr1
Name: connector enhancer of kinase suppressor of Ras 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194231
Homologene: 4604
2700046A07Rik
Name: RIKEN cDNA 2700046A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78449
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 13,125,537 bp
  • T to C, chromosome 1 at 164,292,381 bp
  • T to C, chromosome 1 at 180,961,060 bp
  • G to T, chromosome 2 at 76,585,133 bp
  • A to G, chromosome 2 at 76,591,839 bp
  • T to C, chromosome 2 at 155,964,111 bp
  • C to A, chromosome 3 at 89,054,454 bp
  • C to A, chromosome 3 at 108,426,932 bp
  • A to T, chromosome 4 at 11,051,169 bp
  • C to A, chromosome 4 at 98,771,444 bp
  • C to T, chromosome 4 at 134,233,066 bp
  • T to C, chromosome 4 at 137,608,154 bp
  • T to A, chromosome 5 at 43,903,585 bp
  • T to A, chromosome 6 at 29,206,972 bp
  • T to A, chromosome 6 at 37,915,202 bp
  • A to G, chromosome 7 at 15,972,004 bp
  • T to A, chromosome 7 at 90,191,148 bp
  • A to G, chromosome 7 at 122,992,248 bp
  • A to G, chromosome 9 at 24,725,612 bp
  • T to A, chromosome 9 at 54,366,440 bp
  • G to A, chromosome 10 at 81,266,925 bp
  • T to C, chromosome 11 at 3,521,880 bp
  • G to A, chromosome 11 at 52,121,925 bp
  • A to C, chromosome 11 at 68,811,801 bp
  • A to G, chromosome 12 at 54,900,563 bp
  • C to A, chromosome 13 at 23,464,319 bp
  • T to C, chromosome 13 at 41,070,164 bp
  • T to C, chromosome 13 at 100,161,854 bp
  • C to T, chromosome 13 at 100,161,860 bp
  • A to T, chromosome 16 at 4,955,947 bp
  • A to T, chromosome 17 at 20,541,408 bp
  • T to C, chromosome 17 at 84,436,655 bp
  • A to G, chromosome 18 at 62,753,343 bp
  • C to T, chromosome 19 at 5,706,075 bp
  • T to C, chromosome 19 at 29,022,945 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0855 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039034-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.