Strain Name:
C57BL/6J-MtgxR0856Btlr/Mmmh
Stock Number:
039035-MU
Citation ID:
RRID:MMRRC_039035-MU
Other Names:
R0856 (G1), C57BL/6J-MtgxR0856Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Depdc7
Name: DEP domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211896
Homologene: 16386
Kif20a
Name: kinesin family member 20A
Synonyms: Rabkinesin-6, Rab6kifl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: 6720401E04Rik, NuMA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Vps26a
Name: VPS26 retromer complex component A
Synonyms: HB58, H beta 58, Vps26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 30930
VEGA: 10
Homologene: 68420
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 326622
Homologene: 6101
Vit
Name: vitrin
Synonyms: 1700110E08Rik, 1700052E02Rik, 2810429K11Rik, akhirin, AKH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14789
Homologene: 8401
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
A930017K11Rik
Name: RIKEN cDNA A930017K11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100034748
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212390
Homologene: 14173
Cts8
Name: cathepsin 8
Synonyms: Epcs70, Epcs68, CTS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56094
VEGA: 13
Homologene: 129897
Mtnr1a
Name: melatonin receptor 1A
Synonyms: MelR, Mel1a receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17773
HGNC: HGNC:7463
Homologene: 21207
Defb39
Name: defensin beta 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 360214
Homologene: 86857
Kcnip4
Name: Kv channel interacting protein 4
Synonyms: Calp250, KChIP4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80334
Homologene: 23528
Men1
Name: multiple endocrine neoplasia 1
Synonyms: menin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17283
HGNC: HGNC:7010
Homologene: 7418
Rsph9
Name: radial spoke head 9 homolog (Chlamydomonas)
Synonyms: 1700027N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75564
Homologene: 12606
Olfr437
Name: olfactory receptor 437
Synonyms: GA_x6K02T2P3E9-4391088-4390156, MOR261-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258293
Homologene: 122778
Prl7c1
Name: prolactin family 7, subfamily c, member 1
Synonyms: PLP-O, 1600017N11Rik, Prlpo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67505
Homologene: 137377
Gykl1
Name: glycerol kinase-like 1
Synonyms: Gk-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14625
VEGA: 18
HGNC: HGNC:4289
Homologene: 21848
4930597O21Rik
Name: RIKEN cDNA 4930597O21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Tbx20
Name: T-box 20
Synonyms: Tbx12, 9430010M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57246
VEGA: 9
Homologene: 32476
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 6332415K15Rik, 2610312F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70461
Homologene: 11248
Septin8
Name: septin 8
Synonyms: Sepl, Sept8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20362
Homologene: 57205
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,344,655 bp
  • A to G, chromosome 2 at 5,957,652 bp
  • A to T, chromosome 2 at 69,323,918 bp
  • A to G, chromosome 2 at 104,728,092 bp
  • T to C, chromosome 4 at 24,682,092 bp
  • A to C, chromosome 5 at 25,338,409 bp
  • A to G, chromosome 5 at 48,419,210 bp
  • T to C, chromosome 6 at 43,167,411 bp
  • C to A, chromosome 6 at 66,896,465 bp
  • G to T, chromosome 6 at 124,854,933 bp
  • A to T, chromosome 7 at 80,595,624 bp
  • C to A, chromosome 7 at 101,998,948 bp
  • T to A, chromosome 8 at 19,052,966 bp
  • A to G, chromosome 8 at 21,997,631 bp
  • A to G, chromosome 8 at 45,087,833 bp
  • A to G, chromosome 9 at 24,725,612 bp
  • C to A, chromosome 9 at 32,260,220 bp
  • A to G, chromosome 9 at 42,378,077 bp
  • A to C, chromosome 10 at 62,468,410 bp
  • A to G, chromosome 11 at 53,537,870 bp
  • A to G, chromosome 13 at 27,773,734 bp
  • A to T, chromosome 13 at 61,250,916 bp
  • T to C, chromosome 17 at 25,948,027 bp
  • G to A, chromosome 17 at 46,134,968 bp
  • G to T, chromosome 17 at 78,619,657 bp
  • T to C, chromosome 18 at 34,631,218 bp
  • T to A, chromosome 18 at 52,695,369 bp
  • A to G, chromosome 19 at 6,335,858 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0856 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039035-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.