Strain Name:
C57BL/6J-MtgxR0880Btlr/Mmmh
Stock Number:
039047-MU
Citation ID:
RRID:MMRRC_039047-MU
Other Names:
R0880 (G1), C57BL/6J-MtgxR0880Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 47, WBE1, Cyn, Cycn, Whi, Dz, Edy, Todo, Obt, GENA 60, Flo, Gena 52, Mt, A730019I05Rik, Lda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Ess2
Name: ess-2 splicing factor
Synonyms: Dgsi, ES2, Es2el, Dgcr14, D16H22S1269E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27886
VEGA: 16
Homologene: 11184
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: Grp58, ERp61, PDI, ERp60, PDI-Q2, Erp, Plca, ERp57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: Camsap1l1, 4930541M15Rik, 1600013L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67886
Homologene: 18927
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: Death receptor 6, TR7, DR6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Siglech
Name: sialic acid binding Ig-like lectin H
Synonyms: Siglec-H, 6430529G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233274
Homologene: 48041
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: Gcn5l2, PCAF-B/GCN5, Gcn5, 1110051E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: USH1D, 4930542A03Rik, ahl, mdfw, sals, nmf252, nmf181, nmf112, bob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Astn2
Name: astrotactin 2
Synonyms: Astnl, 1d8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56079
Homologene: 77850
Bmpr1b
Name: bone morphogenetic protein receptor, type 1B
Synonyms: CFK-43a, BMPR-IB, Acvrlk6, Alk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12167
HGNC: HGNC:1077
Homologene: 20322
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232400
Homologene: 45969
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225898
VEGA: 19
Homologene: 27044
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Egfr-rs, Dist1, Dist
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13650
Homologene: 32085
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, SPEGalpha, SPEGbeta, Apeg1, BPEG, SPEG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: 1110020C03Rik, Wdr65, C130004B06Rik, LOC384050
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Iftap
Name: intraflagellar transport associated protein
Synonyms: B230118H07Rik, NWC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68170
Homologene: 16348
A430078G23Rik
Name: RIKEN cDNA A430078G23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Nfe2
Name: nuclear factor, erythroid derived 2
Synonyms: NF-E2, p45, p45nf-e2, p45NFE2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18022
HGNC: HGNC:7780
Homologene: 4491
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin-1, Pyhin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320452
Homologene: 27943
1700021A07Rik
Name: RIKEN cDNA 1700021A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,405,061 bp
  • T to C, chromosome 1 at 136,280,970 bp
  • T to A, chromosome 1 at 173,644,813 bp
  • T to A, chromosome 2 at 101,576,110 bp
  • G to A, chromosome 2 at 121,432,377 bp
  • A to C, chromosome 2 at 181,236,135 bp
  • G to T, chromosome 3 at 141,870,796 bp
  • G to A, chromosome 4 at 8,839,410 bp
  • A to G, chromosome 4 at 65,648,330 bp
  • A to T, chromosome 4 at 118,581,838 bp
  • G to A, chromosome 6 at 3,377,064 bp
  • A to G, chromosome 6 at 48,475,935 bp
  • A to G, chromosome 6 at 128,560,646 bp
  • T to C, chromosome 6 at 136,709,832 bp
  • G to A, chromosome 7 at 55,769,387 bp
  • A to G, chromosome 7 at 100,305,909 bp
  • T to C, chromosome 7 at 141,637,357 bp
  • A to G, chromosome 8 at 3,389,032 bp
  • A to G, chromosome 10 at 21,425,342 bp
  • A to G, chromosome 10 at 60,406,421 bp
  • T to C, chromosome 11 at 32,213,432 bp
  • A to G, chromosome 11 at 100,705,951 bp
  • A to T, chromosome 11 at 103,913,372 bp
  • A to G, chromosome 12 at 53,139,508 bp
  • T to C, chromosome 14 at 37,080,634 bp
  • T to C, chromosome 15 at 103,249,262 bp
  • A to G, chromosome 16 at 17,911,187 bp
  • G to A, chromosome 17 at 43,037,842 bp
  • A to G, chromosome 19 at 8,940,915 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0880 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039047-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.