Strain Name:
C57BL/6J-MtgxR0890Btlr/Mmmh
Stock Number:
039053-MU
Citation ID:
RRID:MMRRC_039053-MU
Other Names:
R0890 (G1), C57BL/6J-MtgxR0890Btlr
Major Collection:

Gene Information

Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22393
Homologene: 4380
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: Usp31, 2810449C13Rik, D330022K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 170707
Homologene: 12988
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: 2700078H01Rik, A330032P03Rik, RPC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70428
VEGA: 10
Homologene: 6981
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66691
Homologene: 32637
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Jmjd6
Name: jumonji domain containing 6
Synonyms: PSR, 5730436I23Rik, Ptdsr, PtdSerR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 107817
Homologene: 9046
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68273
Homologene: 9806
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, tf, Itpr-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Kifc5b
Name: kinesin family member C5B
Synonyms: kinesin family c-terminal 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16580
VEGA: 17
HGNC: HGNC:6389
Homologene: 83229
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 672511
Homologene: 45439
Dhdh
Name: dihydrodiol dehydrogenase (dimeric)
Synonyms: 1300018L09Rik, Xld-1, Xld1, B830008H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71755
Homologene: 8709
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14918
Homologene: 71540
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 320631
Homologene: 87255
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20274
Homologene: 2237
Olfr183
Name: olfactory receptor 183
Synonyms: GA_x54KRFPKG5P-55229158-55230087, MOR183-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258478
Homologene: 27178
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, ENSMUSG00000022188, EY-cadherin, 1700040A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239096
VEGA: 14
Homologene: 56951
2010305A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Dnaic1
Name: dynein, axonemal, intermediate chain 1
Synonyms: b2b1526Clo, 1110066F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68922
HGNC: HGNC:2954
Homologene: 8122
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Tmem168
Name: transmembrane protein 168
Synonyms: 5730526F17Rik, 8430437G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101118
Homologene: 11202
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 260305
Homologene: 9024
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 9530023M17Rik, 0610009F02Rik, 1110054A01Rik, 5830443C21Rik, 5830406C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76073
VEGA: 19
Homologene: 12632
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269437
Homologene: 88833
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239122
Homologene: 12903
Vmn1r38
Name: vomeronasal 1 receptor 38
Synonyms: V1rc13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171186
Homologene: 110800
Olfr3
Name: olfactory receptor 3
Synonyms: Y71, MOR136-14, GA_x6K02T2NLDC-33507606-33506665
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18328
HGNC: HGNC:8208
Homologene: 66579
Olfr551
Name: olfactory receptor 551
Synonyms: MOR29-1, GA_x6K02T2PBJ9-5307445-5306498
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258750
Homologene: 17381
Dhrs13
Name: dehydrogenase/reductase (SDR family) member 13
Synonyms: 2610209N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70451
Homologene: 64807
Mesp1
Name: mesoderm posterior 1
Synonyms: bHLHc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17292
Homologene: 32039
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 404240
Homologene: 83620
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66938
Homologene: 12057
Klra7
Name: killer cell lectin-like receptor, subfamily A, member 7
Synonyms: Ly-49G.3, Ly49g1, Ly49g, Ly49g2, Ly-49G.1, LGL-1, Ly-49G.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16638
Homologene: 110821
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67880
Homologene: 22964
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 28,015,919 bp
  • T to A, chromosome 2 at 34,712,317 bp
  • T to A, chromosome 2 at 36,812,574 bp
  • T to C, chromosome 2 at 66,483,735 bp
  • C to T, chromosome 2 at 180,610,063 bp
  • T to C, chromosome 3 at 63,753,121 bp
  • C to T, chromosome 4 at 41,604,253 bp
  • G to A, chromosome 4 at 108,338,386 bp
  • A to G, chromosome 4 at 116,152,185 bp
  • T to C, chromosome 4 at 126,151,152 bp
  • T to C, chromosome 4 at 137,652,522 bp
  • C to A, chromosome 4 at 152,498,220 bp
  • C to A, chromosome 5 at 36,975,544 bp
  • T to G, chromosome 5 at 115,579,793 bp
  • A to T, chromosome 6 at 13,603,272 bp
  • T to G, chromosome 6 at 66,776,530 bp
  • C to T, chromosome 6 at 130,218,953 bp
  • T to C, chromosome 7 at 7,288,965 bp
  • T to C, chromosome 7 at 45,481,971 bp
  • T to A, chromosome 7 at 48,389,029 bp
  • T to C, chromosome 7 at 79,792,935 bp
  • T to C, chromosome 7 at 98,473,265 bp
  • C to A, chromosome 7 at 102,588,201 bp
  • T to C, chromosome 7 at 120,373,713 bp
  • T to C, chromosome 9 at 32,129,691 bp
  • A to T, chromosome 9 at 79,700,402 bp
  • A to C, chromosome 10 at 84,714,336 bp
  • T to A, chromosome 11 at 78,034,350 bp
  • A to G, chromosome 11 at 116,839,938 bp
  • A to G, chromosome 11 at 119,430,486 bp
  • T to A, chromosome 11 at 120,726,471 bp
  • A to G, chromosome 13 at 55,379,028 bp
  • A to G, chromosome 14 at 33,932,156 bp
  • A to G, chromosome 14 at 54,632,594 bp
  • A to G, chromosome 14 at 59,419,220 bp
  • T to A, chromosome 16 at 58,999,787 bp
  • C to T, chromosome 17 at 26,923,022 bp
  • C to A, chromosome 17 at 27,089,011 bp
  • A to T, chromosome 19 at 36,412,144 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039053-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.